Zachariassenkruse2045

The potential hazard to human health from exposure to heavy metals in surface soil was assessed using 66 soil samples collected from Ahvaz oil field. To this end, the contents of heavy metals were measured by the inductively coupled plasma spectroscopy (ICP-OES). Mean levels of As, Cd, Co, Cr, Cu, Ni, Pb, V, and Zn were 5.9, 0.4, 7.1, 36.5, 41.2, 39.8, 67.4, 31.5, and 77.6 mg/kg, respectively. Contents of all studied heavy metals, with the exception of Co, Cr, and V, were several times higher than that of baselines. Correlation coefficients and principal component analysis (PCA) identified two main groups as sources of heavy metals in the surface soil of Ahvaz oil-field. Metals such as Co, Cr, and V were observed to originate from natural sources and As, Cd, Cu, Ni, Pb, and Zn originated from anthropogenic sources such as petroleum leakage and the pollution caused by drilling mud from oil wells. Pb and Zn were of significantly high EF mean enrichment value, and Co, Cu, Cd, and As had high enrichment in surface soil. Pb, Cr, V, Zn, Co, Cu, Ni, and As had a low potential ecological risk (PER) whereas Cd had a moderate PER. The risk of carcinogenic and non-carcinogenic diseases was detected to be higher in children than in adults. The carcinogenic risk (Cr) calculation was more than 1 × 10-6 for children and adults. Additionally, the CR of Cr for both children and adults indicated risk under control conditions.Given that all in-situ analytical techniques have a non-zero beam size, all measured profiles, resulting from diffusion or otherwise, will be artefactually elongated to some degree. Profiles where the total length over which the concentration changes approaches the resolution of the analytical technique likely suffer from serious convolution; the measured profiles may be considerably elongated relative to the true profile. Resolving this effect is non-trivial, except for some specific combinations of profile type and beam geometry. In this study, a versatile method for numerically deconvoluting diffusion profiles acquired using techniques with Gaussian, Lorentzian, (pseudo-)Voigt, circular/elliptical or square/rectangular interaction volumes, is presented. A MATLAB code, including a user-friendly interface (PACE-the Program for Assessing Convolution Effects in diffusion studies), is also provided, and applied to several experimental and natural profiles interpreted as resulting from diffusion, showing various degrees of convolution.

The insertion of an implantable central venous access is performed according to a variety of approaches which allow the access to the subclavian vein, yet the supraclavicular technique has been underused and never compared to the other methods. The aim of this study was to testify on the efficacy and safety of the subclavian puncture without ultrasound guidance « Yoffa » in comparison with the classical infraclavicular approach (ICA).

This is a retrospective study with prospective data collection on patients followed at the national oncology institute for cancer, in the period extending from May 1st 2017 to August 31st 2017. All patients had a totally implantable central venous access device inserted by the same surgeon AS for chemotherapy administration and demographic characteristics, as well as procedure details were examined. The primary outcomes were the intraoperative complications, while the secondary outcomes represented immediate postoperative and mid-term complications (at 15 months of follow upapproach is linked to higher success rates and less arterial punctures, thereby proving to be a safe and reliable approach.Protein sulfhydryl residues participate in key structural and biochemical functions. Alterations in sulfhydryl status, regulated by either reversible redox reactions or by permanent covalent capping, may be challenging to identify. To advance the detection of protein sulfhydryl groups, we describe the production of new Rabbit monoclonal antibodies that react with carbamidomethyl-cysteine (CAM-cys), a product of iodoacetamide (IAM) labeling of protein sulfhydryl residues. These antibodies bind to proteins labeled with IAM (but not N-ethylmaleimide (NEM) or acrylamide) and identify multiple protein bands when applied to Western blots of cell lysates treated with IAM. The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (genevWF), Jagged 1 (geneJAG1), Laminin subunit alpha 2 (geneLAMA2), Thrombospondin-2 (geneTSP2), and Collagen IV (geneCOL4)) but do not recognize specific proteins such as Bovine serum albumin (geneBSA) and human Thrombospondin-1 (geneTSP1), Biglycan (geneBGN) and Decorin (geneDCN). Scanning mutants of the peptide sequence used to generate the CAM-cys antibodies elucidated residues required for context dependent reactivity. In addition to recognition of in vitro labeled proteins, the antibodies were used to identify selected sulfhydryl-containing proteins from living cells that were pulse labeled with IAM. Further development of novel CAM-cys monoclonal antibodies in conjunction with other biochemical tools may complement current methods for sulfhydryl detection within specific proteins. click here Moreover, CAM-cys reactive reagents may be useful when there is a need to label subpopulations of proteins.

Clinical factors may influence endometrial cancer survival outcomes. We examined the prognostic significance of age, body mass index (BMI), and type 2 diabetes among molecular subgroups of endometrial cancer.

This was a single institution retrospective study of patients who underwent surgery for endometrial carcinoma between January 2007 and December 2012. Tumors were classified into four molecular subgroups by immunohistochemistry of mismatch repair (MMR) proteins and p53, and sequencing of polymerase-ϵ (POLE). Overall, cancer-related, and non-cancer-related mortality were estimated using univariable and multivariable survival analyses.

Age >65 years was associated with increased mortality rates in the whole cohort (n = 515) and in the "no specific molecular profile" (NSMP) (n = 218) and MMR deficient (MMR-D) (n = 191) subgroups during a median follow-up time of 81 months (range 1‒136). However, hazard ratios for cancer-related mortality were non-significant for NSMP and MMR-D. Diabetes was associated with increased overall and non-cancer-related mortality in the whole cohort and MMR-D subgroup.