Haletilley1906
in overweight/obese patients and open the possibility for new therapies that involve these metabolic targets.
Short stature has been linked with the development of metabolic syndrome (MetS). However, only one study has been conducted in Latin American adults. We aimed to assess the association between short stature and MetS in workers of a private educational institution in Peru. In addition, we evaluated the association between height and surrogate markers of insulin resistance (IR).
We performed an analytical cross-sectional study. We categorized the height in tertiles and evaluated MetS according to the Latin American Diabetes Association statement. We used the triglycerides and glucose (TyG) index and the triglycerides to HDL-cholesterol (TG/HDL-c) ratio as IR markers. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between height tertiles and MetS. For the IR markers, we carried out crude and adjusted linear regressions.
We analyzed 1080 participants and the overall prevalence of MetS was 16.2%. In the adjusted Poisson generalized linear model, using the high representative samples to define the threshold of short stature with better sensitivity and specificity for the screening of MetS.
Cholesterol and ketone bodies are synthesized in liver from a common precursor acetyl coenzyme A (acetyl-CoA). Statins by inhibiting cholesterol synthesis may lead to accumulation of acetyl-CoA in hepatocytes and its diversion towards ketogenesis. Ketone bodies may act as alternative energy source thus sparing blood glucose and contributing to hyperglycemia. The present study aims to assess the effect of Atorvastatin therapy on blood ketone levels and glycemic control in patients with T2DM.
Study included 24 statin naïve subjects with T2DM. They were prescribed tablet Atorvastatin at dose of 10mg once daily at bedtime. Ongoing anti-diabetic medications were not changed. Estimation of blood ketones, urine ketones, fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), glycated hemoglobin (HbA1c) and lipid parameters was carried out at baseline and at 3 months after starting Atorvastatin.
There was moderate but significant increase in blood ketones (0.16±0.08mmol/L vs. 0.26±0.07mmol/L; p-value=0.0000), FPG (133.8±17.91mg/dL vs. MLT-748 cost 143.3±22.99mg/dL; p-value=0.0016) and PPG (193.0±36.54mg/dL vs. 211.0±49.51mg/dL; p-value=0.0344) after 3 months of Atorvastatin therapy. This was associated with significant reduction in serum total cholesterol and low density lipoprotein cholesterol.
Three months therapy with Atorvastatin at the dose of 10mg once daily at bedtime in patients with T2DM resulted in moderate rise in blood ketone levels, FPG and PPG in addition to improvement in lipid parameters.
Three months therapy with Atorvastatin at the dose of 10 mg once daily at bedtime in patients with T2DM resulted in moderate rise in blood ketone levels, FPG and PPG in addition to improvement in lipid parameters.
Associated with severe complications and morbidity, Diabetes Mellitus is a significant public health burden. The need for regular monitoring and adherence to treatment and lifestyle changes have a high impact on the quality of life of the patients. This study attempts to assess the effect of smartphone-based lifestyle modification intervention in the quality of life of patients with type 2 Diabetes through a randomized filed trial.
A randomized field trial was performed among the patients attending the outpatient department of a tertiary care hospital in Mysuru city. A mobile application named DIAGURU, mainly focusing on the lifestyle modification and medication management was used for a period of 6 months from April 2019 to September 2019 by 150 patients in the intervention group while another 150 participants served as controls. The quality of life was assessed using the WHO QOL BREF questionnaire at the beginning of the study and after six months.
The change in the quality of life in a positive direction was significantly higher in the intervention group compared to the non-intervention group after six months. The differences in the change in scores of quality of life of participants recruited in intervention and non-intervention groups were statistically significant in all the four domains after the intervention with a p value<0.001.
The evidence generated in this study suggest that such technological approaches can be used as a public health measure to improve the quality of life of patients with type 2 Diabetes Mellitus.
The evidence generated in this study suggest that such technological approaches can be used as a public health measure to improve the quality of life of patients with type 2 Diabetes Mellitus.
COVID-19 is a pandemic, resulting in large number of deaths all over the world. Lack of effective antiviral agents and vaccines pose a major challenge to control this pandemic.
Review the role of reverse quarantine in the control of COVID-19.
Public health measures like social distancing, wearing face mask and hand hygiene along with quarantine measures form important steps to control the disease. Reverses quarantine is a useful strategy to reduce morbidity and mortality associated with COVID-19.
Reverse quarantine is a promising public health measure to reduce the morbidity and mortality associated with COVID-19.
Reverse quarantine is a promising public health measure to reduce the morbidity and mortality associated with COVID-19.
This study aimed to investigate the nutrient contents and the anti-hyperglycemic effect of the immature endosperm of sugar palm (IESP) (Borassus flabellifer L.) fruit on type-2 diabetes mellitus (T2DM) patients.
This is a short type case study where patients (n=30) with T2DM were randomly selected and fed IESP (100mL) twice a day after a regular meal and continued this experiment up to 4th weeks.
The mean fasting blood glucose (FBG) level was markedly reduced from 1st week (15.74mmol/L) to 4th week (10.53mmol/L) among the patients who had normal body mass index (18.5-24.9). Only 16.67% diabetic patients had irregular FBG levels where 10% were in the previous stages after finishing the experimental period, and exceptionally in the case of 6.67% diabetic patients, this therapeutic juice was unsuccessful because of their irregular intake of insulin. The IESP was more effective on female (p≤0.001) patients than males (p≤0.05).
The IESP could be considered as anti-hyperglycemic fruit, and this might be due to its nutrient contents, especially phytochemicals, fiber, sodium, potassium, copper, and zinc.
