Alstrupdennis8921

0 cm) known only from Korea and Spain registered narrow gauge trackways indicating semi-terrestrial/terrestrial quadrupedal gaits. Epertinib Both ichnogenera, from ichnofamily Batrachopodidae, have been attributed to Protosuchus-like semi-terrestrial crocodylomorphs. The occurrence of bipedal B. grandis ichnosp. nov. is evidence of such adaptations in the Korean Cretaceous.Scalable, low power, high speed data transfer between cryogenic (0.1-4 K) and room temperature environments is essential for the realization of practical, large-scale systems based on superconducting technologies. A promising approach to overcome the limitations of conventional wire-based readout is the use of optical fiber communication. Optical fiber presents a 100-1,000x lower heat load than conventional electrical wiring, relaxing the requirements for thermal anchoring, and is also immune to electromagnetic interference, which allows routing of sensitive signals with improved robustness to noise and crosstalk. Most importantly, optical fibers allow for very high bandwidth densities (in the Tbps/mm2 range) by carrying multiple signals through the same physical fiber (Wavelength Division Multiplexing, WDM). Here, we demonstrate for the first time optical readout of a superconducting nanowire single-photon detector (SNSPD) directly coupled to a CMOS photonic modulator, without the need for an interfacing device. By operating the modulator in the forward bias regime at a temperature of 3.6 K, we achieve very high modulation efficiency (1,000-10,000 pm/V) and a low input impedance of 500 Ω with a low power dissipation of 40 μW. This allows us to obtain optical modulation with the low, millivolt-level signal generated by the SNSPD.Endometriosis are characterized by dense fibrous tissue. Numerous studies have investigated roles of inflammation on the pathophysiology of endometriosis. However, the interplay of inflammation and fibrosis remains to be clarified. Here we show that low levels of interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNFα) promoted a fibrotic phenotype, whereas high levels of IL-1β and TNFα inactivated the fibrotic phenotype of endometriotic stromal cells (Ectopic-ES). IL-1β 10 pg/mL and TNFα 100 and 1,000 pg/mL had minimal effects, whereas the highest dose of IL-1β (100 pg/mL) significantly decreased collagen gel contraction in Ectopic-ES. Furthermore, in Ectopic-ES, low levels of IL-1β (1 pg/mL) and/or TNFα 10 pg/mL significantly increased Col I mRNA expression, whereas higher doses of IL-1β (10 and/or 100 pg/mL) and/or TNFα (100 and/or 1,000 pg/mL) significantly decreased Col I and/or αSMA mRNA expression and the percentage of cells with Col I + and/or αSMA + stress fibers. In contrast, in either menstrual endometrial stromal cells of patients with endometriosis or those of healthy women, varying doses of IL-1β and/or TNFα had no significant effects on either Col I or αSMA mRNA/protein expression. The present findings bring into question whether we should still continue to attempt anti-inflammatory treatment strategies for endometriosis.An increasing population in conjunction with a changing climate necessitates a detailed understanding of water abundance at multiple spatial and temporal scales. Remote sensing has provided massive data volumes to track fluctuations in water quantity, yet contextualizing water abundance with other local, regional, and global trends remains challenging by often requiring large computational resources to combine multiple data sources into analytically-friendly formats. To bridge this gap and facilitate future freshwater research opportunities, we harmonized existing global datasets to create the Global Lake area, Climate, and Population (GLCP) dataset. The GLCP is a compilation of lake surface area for 1.42 + million lakes and reservoirs of at least 10 ha in size from 1995 to 2015 with co-located basin-level temperature, precipitation, and population data. The GLCP was created with FAIR (findable, accessible, interoperable, reusable) data principles in mind and retains unique identifiers from parent datasets to expedite interoperability. The GLCP offers critical data for basic and applied investigations of lake surface area and water quantity at local, regional, and global scales.Panicle architecture directly affects crop productivity and is a key target of high-yield rice breeding. Panicle length strongly affects panicle architecture, but the underlying regulatory mechanisms are largely unknown. Here, we show that two quantitative trait loci (QTLs), PANICLE RACHIS LENGTH5 (Prl5) and PRIMARY BRANCH LENGTH6 (Pbl6), independently regulate panicle length in rice. Prl5 encodes a gibberellin biosynthesis enzyme, OsGA20ox4. The expression of Prl5 was higher in young panicles resulting in panicle rachis elongation. Pbl6 is identical to ABERRANT PANICLE ORGANIZATION 1 (APO1), encoding an F-box-containing protein. We found a novel function that higher expression of Pbl6 is responsible for primary branch elongation. RNA-seq analysis revealed that these two genes independently regulate panicle length at the level of gene expression. QTL pyramiding of both genes increased panicle length and productivity. By combining these two genes in various combinations, we designed numerous panicle architecture without trade-off relationship.Symbiotic microbes can enable their host to access untapped nutritional resources but may also constrain niche space by promoting specialization. Here, we reconstruct functional changes in the evolutionary history of the symbiosis between a group of (semi-)aquatic herbivorous insects and mutualistic bacteria. Sequencing the symbiont genomes across 26 species of reed beetles (Chrysomelidae, Donaciinae) spanning four genera indicates that the genome-eroded mutualists provide life stage-specific benefits to larvae and adults, respectively. In the plant sap-feeding larvae, the symbionts are inferred to synthesize most of the essential amino acids as well as the B vitamin riboflavin. The adult reed beetles' folivory is likely supported by symbiont-encoded pectinases that complement the host-encoded set of cellulases, as revealed by transcriptome sequencing. However, mapping the occurrence of the symbionts' pectinase genes and the hosts' food plant preferences onto the beetles' phylogeny reveals multiple independent losses of pectinase genes in lineages that switched to feeding on pectin-poor plants, presumably constraining their hosts' subsequent adaptive potential.