Thurstongreene8785

The aim of this study was to investigate the hold-by-hold climbing fluency dynamics by using an instrumented holds system that measured the contact time on each hold. Forty-four competitive climbers have been analysed in a regional lead climbing competition during a route composed of 41 instrumented holds on 11 m high artificial climbing wall and with a grade of difficulty 6b on the French scale (IRCRA reported scale 13). After removing 10 climbers who fell before the top of the route, the 34 remaining climbers who completed the route were clustered according to their total contact time on each hold. The hierarchical cluster analysis distinguished four profiles of climbing fluency dynamics, on the basis of six 'crux' points, showing that the fastest climbers at the crux points were those with the shortest climbing time. This new instrumented-holds system appeared very innovative as it provides an instantaneous feedback to coaches regarding inter-limbs fluency and subsequent motor organisations.ABSTARCT The PUSH band 2.0 is a wearable technology used to measure mean and peak velocity and power in strength-based movements. The agreement between the PUSH band 2.0 and the criterion measure (force plates) during progressively loaded squat jumps was assessed. Fifteen participants performed 3 squat jumps at increasing loads. Linear regression and Bland-Altman plots assessed data simultaneously recorded from both devices. Mean velocity and power showed deviation from the identity line and an overestimation of 7.40% and 25%, respectively. Peak velocity and power showed an overestimation of 14% and underestimation of 6%, respectively. The results support the use of Push Band 2.0 to measure velocity during ballistic squat movements. However, errors in power measurement are greater than acceptable to support in-field use. While peak velocity maintains a consistent overestimation bias across various velocities, mean velocity error increases at higher velocities and can only be considered valid at slow velocities.The present study was a cross-sectional comparison of probabilistic structure in the distribution of pitching location among baseball pitchers of various age groups (25 elementary school (ES), 20 junior high school (JH), 15 high school (HS), and 18 college students (CL)). In the results, despite the general age-dependent variations in pitching precision, the difference was reflected not only in error 'size' but also in the 'shape' of error as it was shown by fitting 95% confidence ellipse to the two dimensional distribution of pitch location. While the precision measure as a reflection of trial-by-trial variability of release timing (major axis length of the ellipse) was constant, minor axis length of the ellipse as a reflection of variability in the pitching form of each participant demonstrated significant differences among the groups. In the ES group particularly, the trial-by-trial variability in the trajectory angle of the throwing arm was significantly correlated with the minor axis length; this correlation was far greater than those in older groups. The present study is the first to demonstrate the detailed structure of the variability of pitching location of baseball dependent on age.Chemokines are the large family of chemotactic cytokines that play an important role in leukocyte movement and migration stimulation. Until now, several antibody-cytokine (chemokine) fusion proteins have been investigated in clinical trials because of their ability to evoke the circulating leukocytes far from the tumor site. click here In this case, creating the concentration gradient regarding the chemokine is very important to recruit the circulating leukocytes with maximum performance to the tumor environment. To achieve a proper gradient, the chemokine separation from the tumor antigen-bounded antibody can be very crucial. Thus, we designed a novel linker that can be cleaved by enzymes presented around the tumor site including cathepsin B, urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMPs). Also, it can inhibit tumor progression by competing with the native substrate of key proteases in the tumor microenvironment. The proposed linker was evaluated using some bioinformatics approaches. In silico results showed that the linker is structurally stable and could be detected and cleaved using the mentioned enzymes. Communicated by Ramaswamy H. Sarma.Background Morbidity and mortality associated with elective endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA) must be balanced against the impending risk of aneurysm rupture and the estimated remaining lifetime. The aim of this study is to develop and validate a prognostic model for mortality of patients with AAA treated with EVAR. Methods This retrospective observational study included 251 consecutive patients treated with EVAR for asymptomatic AAA between January 2001 and December 2012 at the University Hospital in Bern, Switzerland. Pre-selection of variables was based on a literature review; least absolute shrinkage and selection operator technique was used for the final variable selection. A Firth's bias reduced Cox proportional hazard model was developed and validated using 10,000 bootstrap samples to predict survival after EVAR. Results The median follow-up time was 5.3 years (range 0.1 to 15.9). At the study closing date 95% of follow-up information was available. The mortality rates were 31.9% at 5 years and 50.5% at the study closing date, respectively. Identified predictors for overall mortality after EVAR were age, hazard ratio (HR) = 2.24 per 10-year increase (95% CI 1.64 to 3.09), the presence of chronic obstructive pulmonary disease (COPD), HR = 2.22 (95% CI 1.48 to 3.31), and lower estimated glomerular filtration rate, HR = 1.24 per 10 ml/min/1.73 m2 decrease (95% CI 1.12 to 1.39). The model showed good discrimination ability, Harrell's C = 0.722 (95% CI 0.667 to 0.778) and was very robust in the bootstrap in-sample validation Harrell's C = 0.726 (95% CI 0.662 to 0.788). Conclusion Higher age, the presence of COPD and impaired kidney function are independent predictors for impaired survival after EVAR. The expected remaining lifetime should be considered in patients with AAA. This prognostic model can help improving patient care; however, external validation is needed prior to clinical implementation.