Mccoysingh7038
Human epidermal growth factor receptor-2 (HER-2) is a protooncogene encoded by ERBB2 on chromosome 17.
Fluoridefluorodeoxyglucose positron emission tomography/computed tomography (
F-FDG PET/CT) examination is frequently used to detect distant metastasis in gastric cancer imaging. This study aimed to investigate the relationship between the data obtained in the
F-FDG PET/CT examination and HER-2 expression status in patients with gastric cancer.
A total of 115 patients diagnosed with gastric cancer between 2016 and 2020, with HER-2 immunohistochemical followed by
F-FDG PET/CT examination for staging purposes were included.
HER-2 immunohistochemical examination revealed 71 patients (61.7%) with negative and 44 (38.3%) with positive results. The median maximum standardized uptake value (SUV
), mean standardized uptake value (SUV
), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) values of patients positive with HER-2 were 9.95, 5, 30.44, and 139.16, respectively, whereas patients ver, the relationship between distant metastasis in the 18F-FDG PET/CT scan and MTV, TLG, tumor diameter, localization, and grade was not statistically significant.
This study aimed to investigate the relationship between the standard uptake value (SUV) of body weight and SUV corrected for lean body mass (SUL) parameters obtained from the prostate gland in gallium-68 (
Ga)-prostate-specific membrane antigen (PSMA) positron emission tomography-computed tomography (PET/CT) with Gleason grade (GG) groups, D'Amico risk groups, and presence of metastases.
Patients with prostate adenocarcinoma who underwent
Ga-PSMA PET/CT for staging at our center between February 2017 and October 2018 were evaluated retrospectively. Maximum SUV (SUV
), SUV
, SUL
, SUL
, SUV
, and SUL
values of the prostate tumor were obtained. The difference in these values between GG groups (≥3, <3) and D'Amico risk (low-moderate/high) groups was evaluated with the Mann-Whitney U test. The area under the curve values of SUV and SUL parameters were compared. In addition, SUV
and SUL
values were obtained from the right liver lobe, and their correlation with body weight was evaluated.
A total of 79 patients were included in the study. Significant differences were found in the prostate SUV
, SUL
, SUV
, SUL
, SUV
, and SUL
values between the GG (≥3 and <3) groups and between D'Amico risk (low-moderate and high) groups. However, no significant difference was found in the discriminative power of any SUV or SUL parameter when compared with each other. A significant difference in any SUV and SUL parameters was found in patients with and without metastasis. Neither liver SUV
value nor SUL
value correlated with the body weight.
The superiority of SUL values obtained from
Ga-PSMA PET to SUV was not determined in our study. SUV parameters can also be used for quantitative analysis in
Ga-PSMA PET.
The superiority of SUL values obtained from 68Ga-PSMA PET to SUV was not determined in our study. SUV parameters can also be used for quantitative analysis in 68Ga-PSMA PET.
Fluorine-fluorodeoxyglucose (
F-FDG) positron emission tomography/computed tomography (PET/CT) is used to monitor the recurrence in thyroid cancer patients when there is suspicion of metastases. De-differentiated lesions become
F-FDG avid with a more aggressive clinical course. The aim of this study was to investigate the use of
F-FDG PET/CT in differentiated thyroid cancer.
Forty-six patients, either with a negative radioiodine scan or clinical progression and suspicions for metastases with differentiated thyroid cancer that were referred to our department for
F-FDG PET/CT scan and evaluated retrospectively. PET/CT findings were correlated with clinical and histopathological findings, serum thyroglobulin (Tg), and anti-Tg levels.
Twenty-six patients (56.2%) were positive for recurrence in
F-FDG PET/CT images. Positive
F-FDG PET/CT findings were significantly correlated with the disease stage and Tg levels. Maximum standardized uptake value did not correlate with other findings or patients' profiles. The cut-off value for Tg was at 52.5 ng/mL having 73.08% sensitivity, 75% specificity, 79.17% positive predictive value, and 68.18% negative predictive value for
F-FDG PET/CT imaging.
F-FDG PET/CT is useful for detecting recurrence in differentiated thyroid cancer. Increased Tg levels and stage of the disease were significantly correlated with
F-FDG positivity.
F-FDG positivity may also provide information about the de-differentiation process that may support the treatment plan.
18F-FDG PET/CT is useful for detecting recurrence in differentiated thyroid cancer. Increased Tg levels and stage of the disease were significantly correlated with 18F-FDG positivity. 18F-FDG positivity may also provide information about the de-differentiation process that may support the treatment plan.
This study investigates the relationship between
fluoride-fluorodeoxyglucose (
F-FDG) positron emission tomography/computed tomography (PET/CT) parameters and histopathological features in patients with early-stage invasive ductal breast carcinoma (IDBC).
Patients with early-stage IDBC who underwent
F-FDG PET/CT scan for staging were included in this retrospective study. The status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2, Ki-67 proliferative index, and grades of tumors were recorded. The conventional metabolic parameters [maximum standard uptake value (SUV
) and average standard uptake value] and volume-based parameters [metabolic tumor volume (MTV) and total lesion glycolysis] of the primary tumor were obtained from the
F-FDG PET/CT images. The associations and correlations between the
F-FDG PET/CT parameters and histopathological features were assessed.
One hundred forty-three patients were included.
F-FDG PET/CT parameters, other values. This study suggests that 18F-FDG PET/CT may provide prognostic information in patients with early-stage IDBC.Plant-plant interactions is one of the key field in ecology, which is important for the efficient nutrient utilization, productivity improvement, and plant community assembly. Arbuscular mycorrhizal fungi are important plant mutualistic microorganisms that connect plant roots to form common mycelial networks (CMNs), which play major roles in transferring nutrients and water and regu-lating plant community dynamics. Recent studies demonstrated that these CMNs could act as conduits for transmitting disease and aphid-induced signals among plants, and activating chemical defence in uninfested neighboring plants. In this review, we introduced recent research advances on the contribution of CMNs on plant interaction, the main factors that influences the functions of CMNs, and the role of CMNs transfer and redistribute nutrients and water among plant. In addition, the mechanism underlying underground chemical signal communication, seedling establishment and plants community assembly were summarized. Finally, we proposed challenges facing CMNs in plant-plant interactions and the practical problems. It would provide reference for further understanding the ecological functions of CMNs in plant-plant interactions.Urban street canyon is one of the most important characteristics and spatial forms of cities. It is one of the most frequently used public spaces in cities, with the most serious automobile exhaust pollution and the largest population density. The unreasonable space configuration and internal composition might decrease self-purification of urban ventilation but increase local air pollutant concentration. Here, we reviewed the impacts of street canyon morphology, street trees, vehicle flow and meteorological factors on the distribution of air pollutants in street canyons. We scrutinized the relevant methods of numerical simulation, wind tunnel experiments, and field monitoring on the distribution and diffusion of air pollutants in street canyons. We recommended that future research should concentrate on the impacts of various parameters on the distribution and diffusion of air pollutants based on the field monitoring data. Meanwhile, further research should develop optimization strategies for street canyon design which is conducive to the dispersion of air pollutants, and put forward scientific support and optimization scheme for the controlling of air pollutants from the perspective of urban planning and pattern optimization.We examined the distribution of melanin during the development of the larvae of Schizothorax o'connori except the eyes with histological method. The results showed that after hatching, the appearance sequence of melanin in different organs were following an order of the outer membrane of neurocranium, the pericardial cavity and the dorsal skin, and the peritoneum and the spinal cord. Specifically, melanin appeared in the outer membrane of neurocranium around 5 DAH (days after hatching), in the pericardial cavity and the back skin at 7 DAH, and in the peritoneum and the spinal cord at 10 DAH. Melanin was found in the skin and internal organs (the outer membrane of neurocranium, the pericardial cavity, the peritoneum, the spinal cord) of S. o'connori at 10 DAH, which was mainly distributed on the back. The appearance and distribution of melanin in the postembryonic development of S. o'connori might be related to the high ultraviolet radiation. Our results could provide reference for further research on the UV protection mechanism of melanin for fish and provide theoretical support for the optimization of rearing conditions for larvae in the plateau.Gobiids are widespread invasive species, with many species from this group usually invade into the same ecosystem simultaneously. Understanding the mechanisms underlying the coexi-stence of different gobiid species in the sympatric habitats is a key issue in fish invasion ecology. Incorporating morphological analyses, spatial distribution survey, and trophic analyses, we examined the coexistence strategy of Mugilogobius myxodermus and related species (the earlier invaders) in Dianchi Lake, Yunnan, China. Our results showed significant differences in morphology and spatial distribution among the four invasive gobies species (i.e., M. myxodermus, Micropercops swinhonis, Rhinogobius giurinus and Rhinogobius cliffordpopei). The spatial niche index of M. selleckchem myxodermus was the highest. Food composition between M. myxodermus and other gobies was significantly different, with the former mainly feeding on Chydorus ovalis and Cypris sp. The trophic diversity index of M. myxodermus was the highest. Overall, we found that morphological differences, spatial niche diffe-rentiation, and trophic niche differentiation contributed to the coexistence of the gobies in Dianchi Lake, which could help M. myxodermus reduce interspecific competition. Importantly, the feeding strategy is the key factor determining population size and habitas of M. myxodermus during their competition with the other gobies, and finally contributing to the dominant position in the study area.We investigated population structure, resource density changes of Larimichthys polyactis and its relationship with environmental factors in spring, based on the survey data of bottom trawl in adjacent sea areas of Zhoushan fishery spawning ground protection area from 2014 to 2019. The results showed that the relationship between body length and body weight of Larimichthys polyactis was W=0.44×10-4×L2.78, and parameter b was less than 3, which indicated that L. polyactis had negative allometric growth in recent years. There was a negative correlation between fullness and body length, with body becoming slender. From 2014 to 2019, body length and weight of L. polyactis were the highest in 2014 and the lowest in 2019. Since 2014, population size of L. polyactis in Zhoushan fishery spawning ground protection area and adjacent sea area had gradually decreased, indicating that the miniaturization of L. polyactis had not altered in recent years. From the perspective of the annual change of resource density, resource density of L.
