Chapmanashby3343
Assessment of the severity of immunological disorders in patients with hlamydia trachomatis (CT) infection and the effectiveness of antibacterial therapy in combination with systemic enzyme therapy for the eradication of pathogenic pathogen and correction of detected violations of the immune system.
84 patients with identified CT infection were divided into 2 clinical groups group 1 (42 people) received antibiotic therapy with doxycycline monohydrate for 10 days, 100 mg 2 times a day (the first dose of 200 mg) at regular intervals (daily dose of 200 mg, course - 2.0 g.) in combination with phlogenzyme, 3 tablets 2 times a day within 14 days. The second clinical group (42 people) received only doxycycline monohydrate therapy at the same doses as in the first clinical group. In all patients with CT infection (84 people) and in the control group (32 practically healthy people), the activity of immune reac-tions in the body was additionally assessed by the level of cytokines (-INF, IL-1, IL-4, IL-6), circulatherapy drugs to correct systemic immunological disorders in patients with CT infection.
The theoretical argumentation of the pathophysiological mechanisms of disorders in the interaction of the most important functional systems made it possible to substantiate new conceptual approaches to the therapy of CT infection, taking into account the level and specific disorders in the universal systems of homeostasis regulation. In particular, a pathophysiological basis has been provided to substantiate the advisability of combining antibacterial therapy with systemic enzyme therapy drugs to correct systemic immunological disorders in patients with CT infection.
Reconstructive plastic surgery is the gold standard in the treatment of primary urethral strictures, but the effectiveness of these methods does not reach 100%. In cases of recurrent urethral strictures, the effectiveness of standard operations is lower than with primary strictures, which requires a search for methods to improve the results of surgical treatment.
To evaluate the structure of the intercellular matrix, the cellular composition and regenerative potential of a plasma enriched in platelets after performing urethroplasty on a biological model.
Experiment was carried out on male rabbits ("Burgundy" breed) weighting 3.0-4.5 kg (18 individuals). 18 animals were divided into two groups an experimental one (contained 9 individuals) and a control one (contained 9 individuals). All animals in each group were subjected to end-to-end plastic surgery of the urethral bulbous region using standard procedures. In the control group 4 ml of 0.9% NaCl isotonic solution was injected along the perimeter of the collagen fibers. This allows to reduce the amount of pathological fibro-scar tissue in the operation area.
The use of platelet-rich plasma helps to accelerate the reparative processes in the spongy body after urethroplasty. Another important positive effect of platelet-rich plasma is an increase in the expression of metalloproteinases, which leads to a decrease in collagen production and the correct orientation of collagen fibers. This allows to reduce the amount of pathological fibro-scar tissue in the operation area.
Chronic recurrent bacterial prostatitis (HRBP) affects the reproductive function and negatively affects the quality of life of men. The multifactorial pathogenesis of this disease causes the failure of antibiotic therapy and some cases, requires an in-depth study of the mechanisms of disease development and additional treatment methods.
of the study to study of the effectiveness of immunoactive therapy (recombinant interferon alpha-2b with an antioxidant complex) in combination with antibacterial therapy in patients with HRBP.
Prospective trial examination and treatment of 62 patients. Two groups I (study) group (n=31) received antibacterial therapy (ABT) and a therapy with recombinant IFN Alpha-2b based medication with antioxidant complex (vitamins E and C), II (control) group (n=31) received only ABT. The examination plan included questionnaires (NIH - CPSI, IPSS, Hamilton), general blood and urine tests, biochemical blood tests, urethral scrapings for PCR diagnostics, plasma testosterone, native, electron microscopy, culture test and immunoferment analysis of the prostate sercet, uroflowmetry, Transrectal ultrasonography (TRUS).
When monitoring the clinical picture according to questionnaires (IPSS, NIH-CPSI, Hamilton scale) and laboratory indicators, 1 month after treatment, a significant reduction in symptoms was observed in both groups, and after 3, 6, and 12 months - in patients of group I.
The Combination of an antibacterial drug and recombinant interferon alpha-2b in the treatment of HRBP provides more effective relief of the infectious and inflammatory process in the long term than antibacterial monotherapy.
The Combination of an antibacterial drug and recombinant interferon alpha-2b in the treatment of HRBP provides more effective relief of the infectious and inflammatory process in the long term than antibacterial monotherapy.Over the past several decades, there has been a significant increase in the prevalence of nephrolithiasis in the general population. Ureteroscopy has become the treatment of choice for a growing number of urologic conditions; ureteroscopy is still relatively new procedure and continue to undergo significant advancement. The recent technical development of small caliber semi rigid and flexible deflectable ureteroscopes and the development of diminutive intra-corporeal lithotripsy probes have made the retrograde access to urinary calculi throughout the entire ureter a more feasible and low-risk technique. The study aims to identify the need for use of laser lithotripsy and/or other ureteroscopic ancillary equipment (ureteric stent, ureteric catheter, forceps and dormia basket) in patient undergoing ureteroscopy for ureteric stone management. A prospective observational study from 2013 to 2015. The study conducted in urosurgical theater in Al-Jumhoori Teaching Hospital. 200 patient with ureteric stone in the study treated by ureteroscopy. The mean age of the patient is 36 years. Ureteroscopy had done in the right side in 98 patients, left side in 83 patients, and bilateral ureteroscopy in 19 patients. LY2874455 clinical trial Ureteric stones found in upper ureter in 86 patients, middle ureteric stone seen in 40 patients, and lower ureteric stone founded in 108 patients, whereas 16 patients had stones at more than one location. Ureteric catheter used in 33 patients, and had been removed after 48-72 hours, while Double J stent had been used in 175 patients and had been removed after 2 to 8 weeks.
