Cohendohn3175

Mean siCAM was elevated for cocaine compared with controls and other drugs (p less then .01); however, mean RANTES and ET-1 levels were not significantly different for any drug exposure groups. Receiver operating characteristics curve analysis for prediction of in-hospital ACVE revealed excellent performance of siCAM-1 (area under curve, 0.86; p less then .001) but lack of predictive utility for either RANTES or ET-1. These results suggest that serum siCAM-1 is a viable biomarker for acute cocaine overdose and that endothelial dysfunction may be an important surrogate for adverse cardiovascular events following any drug overdose. © 2020 Society for the Study of Addiction.Secondary prevention encompasses the reduction of further stroke and TIA, any other vascular disease, cognitive decline and dementia, mood disturbances and poor quality of life. Tailored secondary prevention applies to almost all patients with stroke or TIA and can reduce stroke recurrence by 80%. Unfortunately, the risk of recurrent stroke remains elevated at 2.5-4% per year in patients treated with high doses of statin and antiplatelet therapies after stroke and TIA. (2) especially in those with cervical or intracranial large artery atherosclerosis. (2). This article is protected by copyright. All rights reserved.Electroactive organic molecules have received a lot of attention in the field of electronics because of their fascinating electronic properties, easy functionalization and potential low cost towards their implementation in electronic devices. In recent years, electroactive organic molecules have also emerged as promising building blocks for the design and construction of crystalline porous frameworks such as Metal-Organic Frameworks (MOFs) and Covalent-Organic Frameworks (COFs) for application in electronics. Such porous materials present certain additional advantages such as, for example, an immense structural and functional versatility, combination of porosity with multiple electronic properties and the possibility of tuning their physical properties by post-synthetic modifications. In this review, we summarize the main electroactive organic building blocks used in the past few years for the design and construction of functional porous materials (MOFs & COFs) for electronics with special emphasis on their electronic structure and functionality relationships. The different building blocks have been classified based on the electronic nature and main function of the resulting porous frameworks. The design and synthesis of novel electroactive organic molecules is encouraged towards the construction of functional porous frameworks exhibiting new functionalities and applications in electronics. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Herein, we report the third generation of fluorescent probes (arylphosphonic acids) to target calcifications, particularly hydroxyapatite (HAP). In this study, we use highly conjugated porphyrin-based arylphosphonic acids and their diesters, namely  5,10,15,20-Tetrakis[ m -(diethoxyphosphoryl)phenyl] porphyrin ( m -H 8 TPPA-OEt 8 ),   5,10,15,20-Tetrakis [ m -phenylphosphonic acid] porphyrin ( m -H 8 TPPA ), in comparison with their positional isomers 5,10,15,20-Tetrakis[ p -(diisopropoxyphosphoryl)phenyl] porphyrin  ( p -H 8 TPPA-iPr 8 ),  5,10,15,20-Tetrakis [ p -phenylphosphonic acid] porphyrin ( p -H 8 TPPA ) which have phosphonic acid units bonded to sp 2  carbons of the fluorescent core. The conjugation of the fluorescent core is thus extended to the (HAP) via the sp 2  bonded -PO 3 H 2  units, which generates increased fluorescence upon HAP binding. The resulting fluorescent probes are highly sensitive towards the HAP in rat bone sections. The designed probes are readily taken up by cells. Due to the lower reported toxicity of ( p -H 8 TPPA ), these probes could find applications in monitoring bone resorption or adsorption, or imaging vascular or soft tissue calcifications for breast cancer diagnosis etc. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The development of batteries and fuel cells has brought to light a need for carbon anode materials doped homogeneously with electrocatalytic metals. In particular, combinations of electrocatalysts in carbon have shown promising activity. A method to derive functional carbon materials is from pyrolysis of metallopolymers. This work describes the synthesis of a bi-functional phosphonium-based system derived from a phosphane-ene network. The olefin functionality can be leveraged in a hydrogermylation reaction to functionalize the material with Ge. Unaffected by this radical addition, the bromide counterion of phosphonium cation can be used to subsequently incorporate a second metal in an ion complexation reaction with CuBr2. The characterization of the polymers and the derived ceramics are discussed. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Silver nanowires (AgNWs) have been extensively studied as a kind of promising nanomaterials in optics, next generation flexible electronics, and energy-related fields, but the stability and the properties from single nanowire level are still needed to be investigated carefully. In this contribution, single palladium@silver nanowire electrodes (Pd@AgNWEs) were successfully prepared by using laser-assisted pulling method and followed by galvanic replacement reaction (GRR). Results show that the chemical stability of AgNWs can be improved greatly through coating a small amount of Pd, and the Pd@AgNWEs exhibit superior electrocatalytic performance towards methanol oxidation reaction. This work can give us a new insight to investigate the performance of devices/catalysts at single particle/nanowire level, which will benefit the research in flexible electronics and energy-related fields. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.OBJECTIVES The objective of the study was to determine whether exposure of pregnant women to stresses caused by World War II (WWII) negatively affected pregnancy and perinatal outcomes. METHODS Individual medical documents deposited in the Gynaecology and Obstetrics Clinic of Medical University, Poznań (1934-1943; N = 7058) were evaluated. Pemigatinib These were divided into two birth cohorts before WWII and during it. Frequency tables were constructed for the numbers of pregnancy outcomes miscarriages, stillbirths, live births, and neonatal deaths, according to the period of birth and sex of a child. The numbers of recorded days were standardized and the numbers of cases per day were computed. Statistical differences in the averages (medians) between periods and years under study were tested. Birth weight, length, and body mass index (BMI) were compared according to the periods related to WWII. RESULTS Significant differences in proportions of males, females, and subjects with unknown sex were found between the periods a higher proportion of males and different structure of/within negative outcomes were found during WWII.