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In summary, our key findings demonstrated that knockdown of MALAT1 served as a potential suppressor of AS by upregulating miR-558 via the downregulation of GSDMD expression.Cardiac involvement in systemic sclerosis (SSc) is rare but leads to poor short-term prognosis. Evidence regarding heart transplantation (HT) is scarce and is based on experience with isolated cases. We present this case with the aim of analysing the characteristics of a patient with SS who has undergone a successful transplant.

The etiopathogenesis of ankylosing spondylitis (AS), which is a chronic, progressive, inflammatory, systemic disease, has not been fully elucidated yet. Thiol-disulfide homeostasis, a component of antioxidant defense, is thought to play a role in the etiology of inflammatory diseases. We aimed to evaluate the existence of oxidative stress in active AS patients with thiol-disulfide homeostasis.

Patients who were found to have high (n 27) and very-high (n 18) activity levels with ASDAS-ESR and 40 healthy controls participated in the study. Serum native-thiol (NT), total-thiol (TT), and disulfide levels were analyzed by an automated colorimetric method.

While TT and NT levels were significantly decreased in patients compared to the control group, the disulfide levels were increased. There was a significant negative correlation between ESR, and NT, TT in both groups and also between hsCRP and NT, TT in very-high active AS patients.TT and NT levels were significantly higher in the nonsteroidal anti-inflammatory drug (NSAID) users compared to those using biological agents.

The deterioration of thiol-disulfide homeostasis in favor of disulfide; correlations between ESR, CRP, and NT, TT support the use of thiol-disulfide variables in determining the disease activity level.

The deterioration of thiol-disulfide homeostasis in favor of disulfide; correlations between ESR, CRP, and NT, TT support the use of thiol-disulfide variables in determining the disease activity level.

Varying reports exist on the clinical impact of erosive hand osteoarthritis (EHOA) in terms of pain and articular function. Few studies have assessed the association of a patient's clinical features with the presence of more severe radiographic disease. The aim was to evaluate clinical and radiographic characteristics in EHOA comparing with non-erosive (NEHOA); to examine pain and functional impairment between EHOA and NEHOA; and correlate functional impairment with clinical findings, pain, and radiographic severity.

62 patients with EHOA and 57 with NEHO were included. Pain was assessed through Visual Analogue Scale (VAS) and Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain subdomain. Functioning was evaluated with the Health Assessment Questionnaire (HAQ) concerning hand function and AUSCAN. Radiographs were scored with the Kallman scale and subchondral erosions with the Verbruggen-Veys method. Student t-tests were used for comparing quantitative data, chi-squared tests for categorical variables, and Pearson or Spearman tests for assessing correlation.

Patients with EHOA reported significantly higher levels of pain on the VAS and AUSCAN (p<0.01). In EHOA, VAS positively correlated with the HAQ and AUSCAN scales (rho=0.68 and 0.77). In NEHOA, Visual Analogue Scale (VAS) positively and strongly correlated with HAQ and AUSCAN (rho=0.84 and 0.89). Nodes, Kallman score and erosions showed a positive but weak correlation with HAQ and AUSCAN in both groups.

Both EHOA and NEHOA participants had functional impairment, but the erosive subtype had higher clinical burden and increased joint damage. This higher clinical burden is attributed mainly to pain.

Both EHOA and NEHOA participants had functional impairment, but the erosive subtype had higher clinical burden and increased joint damage. This higher clinical burden is attributed mainly to pain.Unequal access to homeownership is central to ethno-racial stratification. Ample research demonstrates large ethno-racial disparities that exist in access and outcomes throughout the mortgage process at both the individual and neighborhood levels. The underlying assumption in most of these studies is that the couples applying for a mortgage are ethno-racially homogenous. However, the ethno-racial stratification structure is unclear when examining interracial couples in the mortgage market. This paper draws on annual data from the Home Mortgage Disclosure Act (HMDA) from 2010 to 2017 to assess variation in ethno-racial disparities in loan outcomes associated with different ethno-racial couplings. I show that ethno-racial disparities in loan outcomes vary tremendously when factoring the ethno-racial identity of the co-applicant. Interracial couples involving a black or Latino co-applicant are more likely to experience a high-cost loan or be denied a mortgage than mono-racial white couples. The results for Asian co-applicants vary, depending on the adverse loan outcome. When comparing interracial couples to mono-racial couples, the observed lending pattern provides evidence of a tri-racial hierarchy in the mortgage market.The alt-right is a white supremacist social movement that operates primarily online. Kartogenin solubility dmso Its broader constituency has not been studied systematically. Participants in white supremacist movements tend to join in response to threats to their social and economic status. Quantitative work suggests they come primarily from working- and lower-middle class backgrounds. Alt-right leadership, however, argues their movement successfully mobilizes a more affluent population of college-educated professionals. In this paper, we examine predictors of county-level Internet search volume for alt-right content. Results indicate that counties with larger percentages of college graduates, of highly educated non-white and immigrant groups, and higher poverty levels for college graduates tend to have a higher search volume for alt-right content. We interpret this as evidence that the alt-right appeals to college-educated whites experiencing real or perceived threats to their economic and social status.Immigration and Customs Enforcement (ICE) has rolled out a series of programs that leverage local and state resources to detain and deport undocumented immigrants. There is little understanding, however, about the public safety consequences of mobilizing local police to enforce immigration law. I use ICE administrative records, Uniform Crime Reports, and American Community Survey population estimates to investigate whether and under what circumstances local immigration enforcement is associated with property crime and violent crime. Results show that crime trends in sanctuary and non-sanctuary counties were not significantly different in the first decade of the 2000s. However, after the proliferation of sanctuary practices around 2014, both property crime and violent crime decreased more in sanctuary counties than non-sanctuary counties, net of other predictors of crime. Further, a pooled cross-sectional analysis of 2013-2016 data shows that sanctuary practices strengthen the inverse relationship between proportion foreign-born Latino and property crime, and reverse the positive relationship between proportion native-born Latino and property crime. I theorize that this occurs because sanctuary practices encourage immigrant political integration, have positive spillover effects to non-immigrant Latinx communities, and increase social harmony.This study analyses the gender overeducation gap, meaning differences between partnered men and women in the degree of holding a job with lower requirements compared to one's own education, and how working from home (WfH) affects overeducation. Contextualising education-job mismatches in the digital age, we update an old topic of labour market research considering new options of spatial flexibility via WfH. Using a unique German dataset of the core employed population in 2018 (i.e., individuals that are at least 15 years old and report paid work for at least 10 h per week), our results show a gender overeducation gap, with women at a higher risk of overeducation than men. By applying a latent variable approach with simultaneous regressions to account for potential selection into jobs allowing WfH, we find that the WfH option carries a lower overeducation risk. Moreover, the findings suggest a gender-specific benefit of WfH women show higher overeducation risks among employees without the WfH option, but the gender overeducation gap is closed among those with the WfH option.The theory of compensating wage differentials may explain part of the motherhood wage gap if mothers are more likely than childless women and men to make a trade-off between monetary and non-monetary rewards when looking for a job. Whereas previous studies focus primarily on jobs that employees currently hold, we present a more accurate test of this theory by studying the extent to which childless (wo)men, fathers and mothers trade off wages and family-friendly working conditions (flexibility, no overtime) in looking for a new job. Using a unique vignette experiment in four European countries (N = 7040), we find that the theory of compensating wage differentials is not supported. When presented with fictional job-openings that vary randomly on family-friendly working conditions and wages, mothers are not more likely than fathers or childless men and women to choose jobs with more family-friendly working conditions and lower pay. Instead, we find that mothers are more likely to apply for jobs with lower wages regardless of other job characteristics. These results suggest that the motherhood wage gap may not be explained by compensating wage differentials, but by mothers' higher likelihood of applying for jobs with lower wages.Research evaluating the relationship between work and crime has paid little attention to behavior in the workplace. We evaluate four hypotheses regarding the work-crime relationship (1) Employment and crime are negatively related, (2) Employment displaces offending from the street to the workplace, (3) Work offending emboldens street offending, and (4) Work offending has no association with street offending. Drawing on longitudinal data from a high-risk sample of young adults from The Pathways to Desistance study, we use hybrid fixed effects models with measures of street property offending and workplace property offending to test the hypotheses. Our findings indicate a positive association between work property offending and street property offending with the inclusion of fixed effects. Findings also provide evidence that job quality moderates this relationship. We elaborate on the role of workplace behavior in the broader work-crime relationship and explore the mechanisms underlying the associations we identify.Based on welfare regime theory, scholars have tried to understand cross-national differences in solidarity by constructing 'worlds of welfare attitudes'. Most studies use a variable-centred logic to examine quantitative differences in support for the delivery of welfare provisions. Yet, the worlds of attitudes approach implies that qualitatively distinct logics of social justice exist. Thus, an alternative person-centred approach is needed that uncovers clusters of beliefs about the preferred type of welfare system. This article assesses individual- and country-level profiles of preferences for the principles of equality, equity and need to dissect worlds of distributive justice preferences. Multilevel latent profile analysis is applied to European Social Survey data (2018/2019). Results reveal four individual profiles that each combine distinct preferences for equality, equity and need. On the basis of the distribution of these individual profiles, three country profiles or worlds of distributive justice preferences are identified, which are not institutionally structured.