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To our knowledge, this is the first study to use a single-port robotic system for thyroidectomy. To verify the superior operative outcomes, further clinical trials are necessary.The question over whether to administer clinically assisted nutrition and hydration (CANH) to a dying patient is controversial, with much debate concerning this sensitive issue. The administration of CANH poses clinical and ethical dilemmas, with supporting and opposing views. Proposed positive effects of CANH include preventing thirst, delirium, hypercalcemia, and opioid toxicity. However, CANH has been shown to increase the risk of aspiration, pressure ulcers, infections, and hospital admissions as well as potentially causing discomfort to the patient. Guidance from several national bodies generally advises that the risks and burdens of CANH outweigh the benefits in the dying patient. selleck chemical However, an individualized approach is needed, and the patient's wishes regarding CANH need consideration if they have capacity and can communicate. Otherwise, sensitive discussions are required with the family, enquiring about the patient's prior wishes if there is no advanced care plan and acting in the patient's best interests. The ethical principles of autonomy, beneficence, non-maleficence, and justice need to be applied being mindful of any cultural and religious beliefs and potential misperceptions.Medicaid enrollment increases during economic downturns which imply households using the public health insurance program during coverage gaps due to job loss. However, we provide new evidence demonstrating that the Medicaid program's countercyclical protections against economic downturns are largely concentrated in states with more generous Medicaid eligibility criteria for adults. We exploit the timing of the 2007-2009 Great Recession to compare trends in recession-linked Medicaid enrollment between states with more generous Medicaid eligibility guidelines and states with more restrictive guidelines. For similar effects of the recession, Medicaid enrollment grew larger states in with more generous Medicaid programs. Our work suggests for every 100 people becoming unemployed in states with a restrictive Medicaid program, about 96 would be uninsured, and about 11 would enroll in Medicaid. Conversely, about 49 would be uninsured in a state with more generous Medicaid guidelines and 57 would enroll in Medicaid.A history of maltreatment during childhood (e.g., physical and sexual abuse, neglect) can threaten the fundamental human need to form and maintain relationships across development, which ensure safety and security. Furthermore, parental maltreatment history presents considerable risk for the emergence of disrupted parenting behaviors (i.e., contradictory communication, sexualized/role-reversed behavior, disorientation, intrusiveness/negativity, and severe withdrawal), which in turn are associated with children's social-emotional development. The purpose of the present study was to examine whether experiences of childhood maltreatment during pregnancy can predict risk for disrupted parenting behavior before the birth of the child. Given the inherent variability in parenting behaviors, we were interested in how different types or combinations of experiences of maltreatment during childhood are associated with later parenting behaviors. Data were drawn from 120 women from a longitudinal study that spanned from the third trimester of pregnancy through 3-year postpartum. In the current study, mothers' experiences of childhood maltreatment were assessed during pregnancy, and disrupted parenting behaviors were coded from videotaped mother-infant interactions 1-year postpartum. Four profiles of childhood maltreatment were identified using latent profile analysis low exposure, high exposure, high sexual maltreatment, and high physical and emotional maltreatment. Results revealed that high exposure to multiple types of childhood maltreatment most strongly predicted later disrupted parenting behavior. Women with multiple exposures to different types of maltreatment during childhood may require more intense intervention during pregnancy to prevent risk for the development of disrupted parenting behavior.It is common knowledge that bullying victimization and coping strategies significantly affect the psychological well-being of children. However, which coping strategies are more effective at a particular level of bullying victimization is underexplored. Using survey data from 1,634 children from 10 schools in Wuhan, China, this study aims to investigate the abovementioned research gap. The results of factor analysis suggest that coping strategies of children in China can be divided into three types help-seeking, avoidance, and self-defense. The results of multilevel modeling suggest that children adopting different coping strategies have distinct levels of depression. Help seekers show a significantly lower level of depression than self-defenders and avoiders. However, with increased bullying victimization, the effectiveness of the help-seeking strategy gradually decreases to offset the negative effect of bullying victimization on psychological well-being. Instead, those who adopt the self-defense strategy display a lower level of depression. The findings of this study suggest that there is no single coping strategy that is best for children, and the more effective strategy largely relies on the level of bullying victimization. The findings also imply that without external support, it is almost impossible for children to completely overcome the negative consequences of bullying on their own.Estimating the area under a curve (AUC) is an important subject in many fields of medicine and science. The regression model using B-spline functions provides flexibility in curve fitting, making it suitable for AUC estimation with various types of nonlinear trends. Despite the versatility of the B-spline approach, comprehensive discussions regarding relevant AUC estimation techniques using B-spline functions and their comparison with existing methods cannot be found in extant literature. In this paper, we investigate AUC estimation using B-spline regression and B-spline regression with several penalties, as well as discuss corresponding inferences. We carry out an extensive Monte Carlo study to evaluate the performance of the proposed methods in various realistic pharmacokinetics and analytical chemistry data settings. We show that the proposed methods provide robust and reliable AUC estimation regardless of different types of nonlinear models from scientific and medical research areas. Our proposed method is appropriate for general AUC estimation since it does not require nonlinear model specifications and inference techniques corresponding to the specified model.