Singhholst3480

EC30 and EC50 values are mostly influenced by geometrical distances between nitrogen and sulfur atoms. Furthermore, the simultaneous presence of oxygen and chlorine atoms in mixture can induce the increase in toxicity. At lower effect levels (EC10), nitrogen atom bonded to different groups has the highest impact on mixture toxicity. Thus, the analysis of the descriptors involved in the developed models can give insight into toxic mechanisms of the binary systems.Swift degradation of the coral reef ecosystems urges the need to identify the reef decline drivers. Due to their widespread use, bioaccumulative and toxic characteristics, chlorinated organic compounds, such as chlorinated paraffins (CPs), are regarded as specific pollutants of concern. Yet little is known about the occurrence of CPs in the coral reef ecosystems. This study focuses on the short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs). Their distribution and congener pattern were investigated in the water-SPM-sediment system and in the corals of the Larak coral reef for the first time. Chlorinated paraffins were detected in all the coral species. Their total loadings ranged from 42.1 to 178 ng g-1 dw in coral tissue, from 6.0 to 144 ng g-1dw in the skeleton, and from 55.0 to 240 ng g-1dw in zooxanthellae. Soft corals were found to accumulate more CPs than Scleractinian corals. Zooxanthellae and mucus accumulated more CPs than tissue and skeleton. In most cases, congener group patterns were dominated by C13 (for SCCPs) and C17 (MCCPs) groups, respectively. The congener patterns of CPs altered to some extent between mucus and the remaining coral compartments. High loadings of CPs were detected in the skeleton of the bleached corals. Moreover, a significant negative correlation between the levels of CPs and the symbiodinium density was observed.Increasing heavy metal pollution in wetland ecosystems around the world pose significant health risks to waterbirds, especially the endangered species. We analyzed heavy metal pollution in bird foraging area of Caohai wetland in Guizhou Plateau (China), and used an integrated exposure risk model for assessing heavy metal (Cd, Pb, Cr, Ni, Zn, Sb) exposure risk in birds from the soil, water, plants and benthic invertebrates. There is considerable variation in the extent of heavy metal contamination across the different sampling sites, and Cd and Sb are the main contaminants. The mussel Anodonta showed greater heavy metal accumulation (except for Zn) compared to the snail species C. cathayensis. The different plant species also varied in terms of amount for accumulated heavy metals. The phytophagous together with omnivorous birds were exposed to Cd, Pb, Zn and Ni through plants rather than the soil, whereas the maximum Zn exposure in the omnivorous and carnivorous birds was through consumption of benthic invertebrates. Furthermore, the phytophagous black-necked cranes (Grus nigricollis) were less risk to heavy metal exposure compared to the omnivorous bar-headed goose (Anser indicus) and carnivorous ruddy shelducks (Tadorna ferruginea). The exposure risk of Cr (8.1) was highest, followed by Pb (5.1), Zn (3.8), Sb (1.0), Cd (0.33) and Ni (0.28). The heavy metal assessment heavy metal exposure risk for migratory birds should take into account the exposure from food and soil. Our findings provide new insights into developing measures to minimize heavy metal contamination in migratory birds.Perfluorooctanesulfonic acid (PFOS) is a persistent environmental contaminant previously found in consumer surfactants and industrial fire-fighting foams. PFOS has been widely implicated in metabolic dysfunction across the lifespan, including diabetes and obesity. However, the contributions of the embryonic environment to metabolic disease remain uncharacterized. This study seeks to identify perturbations in embryonic metabolism, pancreas development, and adiposity due to developmental and subchronic PFOS exposures and their persistence into later larval and juvenile periods. Zebrafish embryos were exposed to 16 or 32 μM PFOS developmentally (1-5 days post fertilization; dpf) or subchronically (1-15 dpf). Embryonic fatty acid and macronutrient concentrations and expression of peroxisome proliferator-activated receptor (PPAR) isoforms were quantified in embryos. Pancreatic islet morphometry was assessed at 15 and 30 dpf, and adiposity and fish behavior were assessed at 15 dpf. Concentrations of lauric (C120) and myristic (C140) saturated fatty acids were increased by PFOS at 4 dpf, and PPAR gene expression was reduced. Incidence of aberrant islet morphologies, principal islet areas, and adiposity were increased in 15 dpf larvae and 30 dpf juvenile fish. Together, these data suggest that the embryonic period is a susceptible window of metabolic programming in response to PFOS exposures, and that these early exposures alone can have persisting effects later in the lifecourse.Soil acidification is causing more and more attention, not only because of the harm of acidification itself, but also the greater harm to bacteria brought by some pollutants under acidic condition. Therefore, the toxicities of two typical soil pollutants (perfluorooctane sulfonate (PFOS) and chromium (Cr(VI)) to growth and metabolisms of soil bacteria (Bacillus subtilis as modol) were investigated. Under acidic condition of pH = 5, Cr(VI), PFOS and PFOS + Cr(VI) show stronge inhibition to bacteria growth up to 24.3%, 42.3%, 41.6%, respectively, and this inhibition was about 2-3 times of that at pH = 7. Sanguinarine price Moreover, acid stress reduces the metabolism of bacteria, while PFOS and Cr(VI) pollution futher strengthens this metabolic inhibition involving oxidative stress and cell permeability. The activities of dehydrogenase (DHA) and electron transport system (ETS) at pH = 5 exposed to Cr(VI), PFOS and combined PFOS + Cr(VI) was 21.5%, 16.9%, 23.2% and 8.9%, 32.2%, 19.1% lower than the control, respectively. However, the relative activity of DHA and ETS at pH = 7 are 5-8 and 2-13 times of that at pH = 5, respectively. Isoelectric point, cell surface hydrophobicity and molecular simulation analysis show that the corresponding mechanism is that acidic conditions enhance the interaction between bacteria and PFOS/Cr(VI) through hydrogen bonding, hydrophobic and electrostatic interactions. The results can guide the remediation of acid soil pollution, and provide a reference for the combined toxicity evaluation of heavy metals and micro-pollutants in acid soil.