Hoodgram1729

Liver test abnormalities (LTA) are a frequent extracutaneous manifestation in generalized pustular psoriasis (GPP). Due to possible hepatotoxicity of systemic monotherapy, it is challenging to simultaneously achieve clinical remission and LTA normalization. However, evidence for therapy is lacking. The aim of this study was to assess the effectiveness of combination therapy of acitretin and glycyrrhizin in nine GPP patients with LTA. During the acute phase of GPP, a combination of acitretin (0.5 mg/kg/d PO) and glycyrrhizin (80 mg/d intravenous) was initiated. After 2 weeks, all the patients promptly achieved at least 77% improvement in the severity score of GPP, as well as a significant reduction of liver enzymes. The patients were continuously treated with tapered doses of acitretin (20-30 mg/d PO) and glycyrrhizin (150 mg/d PO), and presented stable conditions during the 12-month follow-up. In conclusion, we consider that the combination of acitretin plus glycyrrhizin is an effective and safe therapy in GPP patients with LTA. © 2020 Wiley Periodicals, Inc.Mobile nuclear magnetic resonance (NMR) is a flexible technique for nondestructive characterization of water in plants, the physical properties of polymers, moisture in porous walls, or the binder in paintings by relaxation measurements. NMR relaxation data report material properties and therefore can also help to characterize the state of tangible cultural heritage. In this work, we discuss the relaxation behavior in two series of naturally aged paint mock-up samples. First, paints with different pigment concentrations were prepared and investigated in terms of the longitudinal and transverse relaxation-time distributions. We document the evolution of both relaxation-time distributions during the initial drying stage and demonstrate the heightened importance of transverse over longitudinal relaxation measurements. Second, we observe nonlinear dependences of the relaxation times on the pigment concentration in a typical oil binder. Third, in a study of naturally aged paint samples prepared in the years between 1914 and 1951 and subsequently aged under controlled conditions, we explore the possibility of determining the age of paintings using partial least square regression (PLS) by fitting T1 -T2 data with the sample age. Our results suggest some correlation, albeit with significant scatter. Estimating the age of a painting stored under unknown conditions from NMR relaxation data is therefore not feasible, as the cumulative effects of light irradiation, humidity, and biological degradation further obfuscate the chemical and physical impact of aging on the relaxation times in addition to the impact of pigment concentration. © 2020 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.BACKGROUND Efficient methods to treat persistent pockets during periodontal maintenance therapy (PMT) require further investigation. The hypothesis of this randomized controlled clinical trial was that local application of enamel matrix derivative (EMD) added to papilla reflection/root preparation (PR/RP) could enhance clinical and inflammatory outcomes, primarily clinical attachment level. METHODS Fifty PMT patients with generalized stage III-IV, grade B periodontitis presenting with a 6-9 mm interproximal PD were randomly allocated to (PR/RP+EMD; n = 24) and control (PR/RP+Saline; n = 26) therapies by gender and smoking status. Roots were treated with reflection of interproximal papillae, root planing assisted with endoscope evaluation, and acid etching, followed by EMD or saline application. Probing depth (PD), clinical attachment level (CAL), plaque index (PI), and interproximal bone height (IBH) were evaluated at baseline and 12 months post-therapy. Gingival crevicular fluid (GCF), bleeding on probing (BOP) and IL-1β were tested (ELISA) at baseline, 2-weeks, 6-and 12 months. Groups were compared over time and between groups with Wilcoxon Rank Sum and t-tests. RESULTS Both PR/RP+ EMD and PR/RP+S resulted in significant improvements in clinical outcomes (PD and CAL, BOP) from baseline to 12 months. No significant differences were found in clinical or inflammatory outcomes between the experimental and control groups. CONCLUSIONS The addition of EMD to PR/RP does not significantly improve clinical or inflammatory outcomes compared to PR/RP alone during periodontal maintenance therapy. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.RATIONALE Dopants in ionic conductors play a crucial role in achieving the required electrochemical properties. A slight variation in their concentration considerably affects crystals' conductivity and their applicability as ionic conductors and laser materials. To ensure the growth of high-quality fluoride crystals, adequate approaches for the quantification of matrix and admixture/dopant components are required. METHODS A panel of SrF2 and GdF3 doped LaF3 single crystals was investigated. The electrical conductivity of the crystals was measured by impedance spectroscopy in the frequency range of 100 Hz - 1 MHz to control for crystals' quality. Pulsed glow discharge mass spectrometry (GDMS) was used to simultaneously quantify fluorine, strontium, lanthanum, and gadolinium in the crystals. X-ray fluorescence (XRF), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM EDX), and arc-optical emission spectrometry were used for validation. RESULTS Quasiperiodic intensity drifts under sputtering of the ionic conductors were observed and attributed to F- redistribution on the sample surface, affecting surface conductivity and sputtering rate. Several sample preparation protocols were tested to cope with that effect. Full coating of the sample with a several-micrometer layer of silver provided stable and effective sputtering. The parameters for the GDMS determination of F, Sr, La, and Gd were optimized. The elements' distribution was studied in different parts of the crystals. CONCLUSIONS An analytical approach to the direct multi-element analysis of fluoride-ionic conductors using pulsed GDMS with La1-x-y Srx Gdy F3-x as an example was designed and tested. Instability effects of ionic conductivity were explained and coped with, providing effective and stable sputtering. read more This article is protected by copyright. All rights reserved.