Floresthomas2641
We compared the patient-reported outcomes (PROs), minimal clinically important difference (MCID) achievement, and perceived postoperative satisfaction after minimally invasive lumbar decompression of patients stratified by self-identified gender.
Patients who had undergone single minimally invasive lumbar decompression were identified. The PRO measures were administered preoperatively and postoperatively and included the PRO measurement information system-physical function, visual analog scale (VAS) for back and leg pain, Oswestry disability index (ODI), and 12-item short form physical and mental component scores. The patients were grouped by self-identified gender. Propensity score matching was performed. The mean PROs and postoperative satisfaction scores were compared between cohorts using a 2-sample t test. The postoperative PRO improvement within each cohort was calculated using a paired t test. MCID achievement was determined by comparison to previously established threshold values. The MCID achievelity, leg pain, back pain, and lifting versus patients in the self-identified female group. Self-identified gender might influence patient satisfaction and could be attributed to differing preoperative expectations at baseline for short-term recovery.
Despite the similar preoperative baseline values, postoperative improvement, and clinical outcomes, our results suggest that the self-identified male patients will have poorer short-term satisfaction for disability, leg pain, back pain, and lifting versus patients in the self-identified female group. Self-identified gender might influence patient satisfaction and could be attributed to differing preoperative expectations at baseline for short-term recovery.
Temporal lobe epilepsy (TLE) is one of the most common causes of medically refractory focal epilepsy. Anterior temporal lobectomy (ATL) leads to improved seizure control in patients with medically refractory TLE. Various auras are associated with TLE; however, the relationships between aura type and outcome after ATL are poorly understood. Our objective was to investigate the associations among clinical features, aura type, and seizure outcome after ATL.
The records of patients who underwent ATL between 1993 and 2016 at a single institution (N= 174) were retrospectively reviewed. Demographic and clinical variables were compared among aura types using analysis of variance and logistic regression analysis. A multiple regression analysis was conducted to determine whether aura type predicted seizure outcome after ATL.
Mesial temporal sclerosis (MTS) on magnetic resonance imaging inversely correlated with cephalic auras (P= 0.0090). Affective auras (P= 0.014) and somatosensory auras (P= 0.021) were correlated with findings of MTS on pathology, whereas this finding was inversely correlated with the presence of auditory auras (P= 0.0056). On multiple regression analysis, predictors of worse seizure outcome after ATL were cephalic auras (P= 0.0048), gustatory auras (P= 0.029), visual auras (P= 0.049), and tonic-clonic seizures (P= 0.047). Fewer preoperative antiepileptic medications (P= 0.0032), and presence of multiple auras (P= 0.011) were associated with better outcome.
Cephalic auras, gustatory auras, and visual auras were associated with worse seizure outcome after ATL.
Cephalic auras, gustatory auras, and visual auras were associated with worse seizure outcome after ATL.
To perform measurements in normal brain imaging studies from the free edge of the falx cerebri to the genu and the body of the corpus callosum and perform a statistical analysis based on age, type of study, and sex highlighting potential surgical implication of these measurements.
In 193 normal brain imaging studies, 3 anatomical points of the corpus callosum were used to measure the distance to the falx cerebri. Horos and RadiAnt DICOM Viewer software were used to perform the measurements. Statistical analysis of data was performed with Minitab18 software.
The results obtained in computed tomography (CT) studies were distance A, mean 2.1065 cm; distance B, mean 2.2677 cm; distance C, mean 1.765 cm. The results obtained in magnetic resonance imaging studies were distance A, mean 1.7148 cm; distance B, mean 2.1197 cm; distance C, mean 1.5321 cm. Statistically significant differences were obtained in measurements related to the type of study and in measurements made in CT studies related to age.
There is a distance from the free edge of the falx cerebri to the genu and body of the corpus callosum of at least 1 cm in both CT and magnetic resonance imaging studies of normal brains. Statistically significant differences were found in the measurements in relation to the type of study and in relation to age in the measurements made in CT studies. These measurements could be important in determining the extent of bone resection in certain types of decompressive craniectomies.
There is a distance from the free edge of the falx cerebri to the genu and body of the corpus callosum of at least 1 cm in both CT and magnetic resonance imaging studies of normal brains. Statistically significant differences were found in the measurements in relation to the type of study and in relation to age in the measurements made in CT studies. buy compound 3i These measurements could be important in determining the extent of bone resection in certain types of decompressive craniectomies.This article mainly dedicates on the issue of finite-time stabilization of complex-valued neural networks with proportional delays and inertial terms via directly constructing Lyapunov functions without separating the original complex-valued neural networks into two real-valued subsystems equivalently. First of all, in order to facilitate the analysis of the second-order derivative caused by the inertial term, two intermediate variables are introduced to transfer complex-valued inertial neural networks (CVINNs) into the first-order differential equation form. Then, under the finite-time stability theory, some new criteria with less conservativeness are established to ensure the finite-time stabilizability of CVINNs by a newly designed complex-valued feedback controller. In addition, for reducing expenses of the control, an adaptive control strategy is also proposed to achieve the finite-time stabilization of CVINNs. At last, numerical examples are given to demonstrate the validity of the derived results.How do whole number arithmetic skills support students' understanding of fraction magnitude during the emerging stages of fraction learning? Chinese students in Grade 4 (N = 1038; Mage = 9.9 years; 55.6% boys) completed assessments of whole number arithmetic skills (i.e., addition, subtraction, multiplication, and division), fraction mapping (i.e., connecting visual fraction representations to fraction notations), and fraction comparison (i.e., comparing magnitudes of fraction symbols). We found that division skills uniquely differentiated students who had a basic understanding of fraction notation (mappers) from students with no understanding of fraction notation (non-mappers). Furthermore, we found that division mediated the relations between all three other arithmetic operations (i.e., addition, subtraction, and multiplication) and fraction mapping performance for the mappers. For fraction comparison, there was evidence of the whole number bias for the majority of students. The current results highlight the importance of the mastery of division skills and its dominance in predicting individual differences in fraction mapping for Chinese students in Grade 4.Chronic kidney disease (CKD) is an growing public health concern associated with high mortality rates. The occurrences of vascular calcification (VC) increase concordantly with the progression of CKD.With CKD, hyperphosphatemia promotes intermediate VC, a process that is further facilitated by vascular smooth muscle cells (VSMCs) initiating osteogenic transdifferentiation. The purpose of this study was to determine the involvement of CKAP4 in VC progression. Clinical investigations demonstrate that elevated blood CKAP4 and matrix metallopeptidase 2 (MMP2) levels are related with CKD in individuals. As an in vitro model, mouse VSMCs were extracted and treated with high levels of phosphates (2.5 mmol/L Pi). We also created an in vivo mice model of CKD induced by 5/6 nephrophrectomies and a high-protein diet (High Pi diet). The expression of CKAP4 and MMP2 in both in vitro and in vivo models was significantly higher in VSMCs and calcified aorta in both models. Additionally, in vitro tests indicated that CKAP4 modulates YAP phosphorylation. Simultaneous silencing of CKAP4 and calcium content assay revealed a significant reduction in the VSMCs and calcium content of the aorta. Alizarin red staining and calcium content assay reveled that silencing of CKAP4 reduced the VSMCs and aortic calcification, accompanied with reduced expression of YAP and MMP2. Overall, our study demonstrates for the first time that CKAP4 contributes to VC in CKD by modulating YAP phosphorylation and MMP2 expression.Increasing research interests have been aroused in exploring the function of long non-coding RNA (lncRNA) in breast cancer and developing lncRNA-targeted diagnosis, treatment and prognosis. In GEPIA2 database, we compared the expression pattern of the lncRNA RP11-214F16.8 in normal mammary tissues and breast cancer tumors and its correlation with the overall death rate of breast cancer patients. Gain- and loss-of function assays were employed to study function of the lncRNA in breast cancer cell lines in vitro while xenograft tumor growth assay was performed to investigate its function in tumorigenesis in vivo. We also used RNA pull-down coupled with mass spectrometry to identify the lncRNA binding partner, and RIP, EMSA, ChIP and Co-IP assays as well to testify these physical interactions.We identified that up-regulation of the lncRNA RP11-214F16.8 is subtype-independently associated with a higher overall death rate in breast cancer patients. Increased RP11-214F16.8 expression endows breast cancer cells enhanced capabilities in the aspects of proliferation, invasion, migration and tumor-initiation, while loss of the lncRNA exerts the opposite effects. Mechanistically, the oncogenic property of RP11-214F16.8 lies to its post-translational repression on the tumor suppressor NISCH via recruiting SENP3-mediated de-SUMOylation and ubiquitin-proteasome-mediated protein degradation. NISCH in turn inhibits the transcription of RP11-214F16.8 through restraining the expression of the transcription factors located downstream of RAC1, PAK1 and ERK1/2 signaling transduction pathways. In all, dysregulation of RP11-214F16.8 not only stimulates activation of the proliferation- and migration-promoting signaling cascades, but also facilitates the removal of restrictions on self-transcription, which ensures the progression of tumorigenesis.
Downregulation of Carnitine palmitoyltransferase-2 (CPT2) has been shown to be highly associated with the progression of several cancers, but little known about its expression, biological functions and mechanisms in colorectal cancer (CRC).
Bioinformatics analysis of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data sets was used to explore the expression of CPT2, the relationship between CPT2 expression and clinicopathologic features, as well as the overall survival of CRC. Cox's proportional hazards regression model was used to analyze independent prognostic factors of CRC. In vitro, CRC tissues were analyzed by RT-qPCR, IHC, IF and western blotting to verify CPT2 expression. Colony formation, CCK-8, cell cycle, apoptosis, transwell and wound healing assays were performed to examine the functions of CPT2 in CRC. In vivo, nude mouse xenograft experiment was used to further examine the effect of CPT2 on tumorigenesis. Furthermore, gene set enrichment analysis (GSEA) was conducted to explore the downstream pathway of CPT2.
