Hanleymouritzen1238

Intraoperative blood loss (IBL) during liver resection is a predictor of morbidity, mortality, and tumor recurrence after hepatectomy; however, there have been few reports on patient factors associated with increased IBL. We enrolled consecutive patients who underwent liver resection for primary liver malignancies, and evaluated the predictors of IBL using a data set in which factors that might influence IBL, such as surgical devices, methods and anesthetic technique, were all standardized. We studied 244 patients. A multivariate analysis revealed that higher IBL was an independent risk factor for post-hepatectomy liver failure grade ≥B and overall survival. Multiple linear regression analyses showed serum creatinine, clinically significant portal hypertension (CSPH), tumor size, and major hepatectomy were all significant predictors of IBL. In conclusion, higher IBL was significantly associated with increased morbidity and mortality in patients with primary HCC who underwent liver resection. The risk of IBL was related to several factors including tumor size, serum creatinine, CSPH, and major hepatectomy.

To evaluate if 3 peptides derived from the cartilage oligomeric matrix protein (COMP), which wounded zones of cartilage secrete into synovial fluid, possess biological activity and might therefore be involved in the regulation of specific aspects of joint regeneration.

The 3 peptides were produced by chemical synthesis and then tested

for known functions of the COMP C-terminal domain from which they derive, and which are involved in osteoarthritis transforming growth factor-β (TGF-β) signaling, vascular homeostasis, and inflammation.

. None of the peptides affected the gene expression of

in osteochondral progenitor cells (

> 0.05). We observed no effects on the vascularization potential of endothelial cells (

> 0.05). In cultured synovium explants, no differences on the expression of catabolic enzymes or proinflammatory cytokines were found when peptides were added (

> 0.05).

The 3 peptides tested do not regulate TGF-β signaling, angiogenesis and vascular tube formation, or synovial inflammation

and therefore most likely do not play a major role in the disease process.

The 3 peptides tested do not regulate TGF-β signaling, angiogenesis and vascular tube formation, or synovial inflammation in vitro and therefore most likely do not play a major role in the disease process.

The consumption of a healthy diet is essential during the preconception period, pregnancy and lactation to guarantee maternal-fetal and newborn health. It is important to take into account when configuring the maternal diet that inadequate intakes of vitamins and minerals, as well as a high consumption of foods or beverages with refined sugar increase the incidence of low birth weight infants, while the adequate consumption of micronutrients and carbohydrates (mainly integral) can decrease it. Prenatal consumption of fish is also associated with less intrauterine growth retardation. Maternal nutritional deficits that lead to intrauterine growth retardation can alter the expression of some genes, causing abnormal programming in organ and tissue development. In response, the fetus adapts to this situation of scarcity and may have difficulties adapting to an abundant consumption of food after birth, increasing its propensity to suffer from cardiovascular and metabolic diseases in adult life. After delivery, th important to identify and prevent these imbalances before conception and during pregnancy and lactation.

Introduction insomnia represents a growing and important health problem. If it persists, it could have a negative impact in people's welfare. Nowadays we have a wide range of techniques to measure and analyze sleep quality and quantity. Objectives to demonstrate the impact of nutrition in sleep disorders. Methods bibliographic review selecting the most relevant papers related to nutrition and its impact on sleep. Results there is a direct correlation between some food or supplements and sleep quality and quantity. In addition, there exist some nutritional maneuvers that can help to prevent or solve some sleep disorders. The relationship between tryptophan and melatonin with the induction and maintenance of the sleep is clear, but vitamins, minerals, macronutrients and some dietetic habits can also have an impact. Conclusions nutrition can have a relevant effect in the prevention and resolution of sleep disorders. Further studies are necessary to assess the real impact of nutritional treatments in insomnia.

Introduction insomnia represents a growing and important health problem. If it persists, it could have a negative impact in people's welfare. Nowadays we have a wide range of techniques to measure and analyze sleep quality and quantity. Objectives to demonstrate the impact of nutrition in sleep disorders. Methods bibliographic review selecting the most relevant papers related to nutrition and its impact on sleep. Results there is a direct correlation between some food or supplements and sleep quality and quantity. In addition, there exist some nutritional maneuvers that can help to prevent or solve some sleep disorders. The relationship between tryptophan and melatonin with the induction and maintenance of the sleep is clear, but vitamins, minerals, macronutrients and some dietetic habits can also have an impact. Conclusions nutrition can have a relevant effect in the prevention and resolution of sleep disorders. Further studies are necessary to assess the real impact of nutritional treatments in insomnia.

The reproductive age of a woman comprises a large part of her life. Suffering from menstrual disorders, such as dysmenorrhea, endometriosis and premenstrual syndrome (PMS), can have serious implications in the lives of those suffering them, so it is important to diagnose these problems and treat them in the most appropriate way. In find more of these problems it is important to carry out a rigorous medical history, in which a complete menstrual history is collected. Analgesic and hormonal pharmacological treatment, dietary therapy, surgery or alternative therapies may be included within the approach of these conditions. Regarding diet, this seems to be an important modulating factor, without having studied with sufficient scientific rigor the real effect it causes in women suffering from menstrual disorders. #link# It is advisable to study each case individually and adapt the dietary-nutritional therapy. In endometriosis, for example, any additional problems such as fertility problems or immune diseases must be considered.