Linkwichmann1522
No Abstract Available.
To evaluate the effect of Brief Guided Imagery (BGI) on patients suffering chronic, fibromyalgia-related pain.
Fibromyalgia is characterized by chronic pain and accompanied by fatigue, depression, sleep problems, decreased daily functioning, and a lack of energy, thus negatively impacting daily functions, mental and physical health, and quality of life.
An exploratory, controlled trial.
The study was conducted at Clalit Health Services (CHS) Physiotherapy Institute, Jerusalem, Israel and approved by the CHS IRB (0015-com2-16).
Thirty-seven female patients diagnosed with fibromyalgia were alternatively allocated to an intervention group 1 (IG1) including 18 patients, or a control group (CG) including 19 patients. Following the first BGI trial, the 16 remaining participants in CG became intervention group 2 (IG2), and 13 patients completed the trial.
All patients completed a Brief Pain Inventory pain questionnaire and an SF-36 satisfaction questionnaire, before and after the intervention.
The findife. We recommend adding BGI to treatment plans for patients suffering chronic, fibromyalgia-related pain. While other guided imagery methods last up to 20 minutes per session, BGI is innovative since only two minutes are required to obtain a positive effect on chronic pain and quality of life measures.Yoga is a spiritual practice to exercise for good health as well as to foster harmonious mind-body connection. The purpose of this exploratory study was to ascertain the effects of the different components of yoga on the health and well-being of primary school children in New Zealand. The impact of yoga practice on children's learning capabilities was also examined. The yoga intervention consisted of one hour weekly sessions taught over a period of 5 weeks in the hall of a school that embraces a model of holistic education in its curriculum delivery. School children participation was voluntary and 6 school children from years 6 - 10 took part as part of a convenience sample in this study. A qualitative hermeneutic-phenomenological epistemology was used in conducting the design of this study. Some of the benefits the school children reported from a regular practice of yoga included deeper relaxation, greater inner calmness, better energy in tackling the challenges of daily life. Yoga was also found to be an effective agent in fostering a socially mediated fun-filled learning environment where children can engage in playful interactions and meaningful bonding. The school children also reported better focus and attention spans in their learning activities.Major depressive disorder is most commonly treated with a combination of medication and psychotherapy. For those people that do not benefit from the standard therapy or prefer non-pharmacologic therapy, folate supplementation may be an option. Folate is normally acquired through the diet and folate deficiency is associated with depression. In the brain, folate is one nutrient among others involved in the production of the neurotransmitters that affect mood. Studies involving folate supplementation for the treatment of depression have had mixed results but have omitted to take into account the genetic polymorphisms, such as the ones in methyltetrahydrofolate reductase (MTHFR), that affect folate metabolism. Supplementation with L-methylfolate may overcome the folate metabolism problems seen in individuals with disadvantageous genetic polymorphisms.Though free radicals have beneficial roles in the body to fight against certain pathogenic diseases as well as are implicated in a number of cellular and physiological activities, elevated levels may be overwhelming for the antioxidant defense system to maintain the normal homeostatic state. This may eventually lead to oxidative stress whereby the increased level of free radicals may attack certain biomolecules (DNA, RNA, proteins lipids and carbohydrates) causing damage to cells, tissues and organs in the body. Following these attacks, certain by-products formed which are indicative of the cellular damage have been identified and considered as biomarkers for assessing oxidative stress. As such, assays have been developed to quantify these oxidative stress markers in body tissues, biological fluids, blood, urine samples etc. Oxidative stress has been associated with several diseases such as diabetes, atherosclerosis, hypertension, respiratory diseases, arthritis, cataract, cancer, cardiovascular diseases etc., as free radicals are implicated in the pathogenesis of these diseases. The antioxidant defense system collectively made up of enzymes and some low molecular weight molecules are usually suppressed in a state of oxidative stress and thus, external sources of antioxidant have been required to supplement the endogenous antioxidants. As such, antioxidant supplementation has been of interest in managing oxidative stress diseases. However, the use of antioxidant supplements remain controversial as some studies have shown possible harmful effects. Thus, there is need for further randomised clinical trials with defined and specified dosage that will make use of suitable controls and biomarkers for various diseases to better predict the efficacy of antioxidant supplements across a broad spectrum of diseases in order to valourise their usage.
Drug repurposing is a relevant approach during the COVID-19 pandemic, because development of new drugs is time-consuming and costly, and the safety of new drugs is paramount. Drug repurposing focuses on researching new indications for existing drugs and can reduce the challenges faced in drug development.
The current review intended to examine the current status of drugs being repurposed for COVID-19 treatment.
The research team performed a literature review, searching relevant literature databases to find abstracts of relevant articles in journals published from 2010 until May 16, 2020. The sources of data included Google Scholar, PubMed, and ScienceDirect. LB-100 price The search terms used included repositioning of drugs, repurposing of drugs and COVID-19 therapy, and SARS-CoV-2 therapy.
The research team conducted this study at the Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan; Mangalbare Hospital, Morang, Nepal; and Dr Iwamura Memorial Hospital, Bhaktapur, Nepal.
