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Our analysis extends such critiques by considering what the digital response to Covid-19 reveals about tech corporations' growing power to influence public health agendas. We discuss how they promote technical solutions to public health challenges that are politically seductive, but that have uncertain effectiveness and societal implications that warrant critical scrutiny.The relationship between phonological knowledge and reading is consistent both in typically developing children and in children with dyslexia. However, children with dyslexia usually show lower phonological skills. In a group of children with dyslexia 8- to 12-year-old we investigated how different long-term memory phonological associations are updated in memory, that is how are kept in mind and replaced when no longer relevant. Response times (RTs) and accuracy rates were collected. Typically, long-term memory associations are dismantled and updated with greater difficulty (longer RTs). We did not replicate these findings in children with dyslexia thus demonstrating the effects of phonological disruption during updating, a mechanism that is preserved overall. In summary, our work advances literature about how phonological knowledge impacts verbal working memory updating.The Postgraduate Fellowship for Migrant and Refugee Health (PGF) is a 13-week programme of training, mentorship and workplace-based assessment for junior doctors working in the Rohingya migrant camps of Bangladesh. To date, four cohorts of 25 doctors who work in Primary Health Centres run by Non-Governmental Organisations (NGOs) have completed the programme. The PGF was developed and delivered by Doctors Worldwide (DWW), a UK-based international charity which aims to improve the health of communities by working in partnership with international, national and grassroots organisations focusing on health access, health improvement and health emergencies. The doctors working in the camps carry a burden of responsibility often out of proportion to their training, experience and seniority. Selleck Resiquimod The isolated nature of the camp health facilities, the paucity of equipment, drugs and facilities and the lack of any senior mentorship mean that clinicians have had to learn new roles and responsibilities on the job. Doctors Worldwide recognised this unique challenge at the start of the crisis in the latter half of 2017 and since 2018 it has successfully run the PGF using an international community of content developers with travelling and local teaching and support.The TREX-2 complex is essential for the general nuclear mRNA export in eukaryotes. TREX-2 interacts with the nuclear pore and transcriptional apparatus and links transcription to the mRNA export. However, it remains poorly understood how the TREX-2-dependent nuclear export is connected to the subsequent stages of mRNA trafficking. Here, we show that the PCID2 subunit of Drosophila TREX-2 is present in the cytoplasm of the cell. The cytoplasmic PCID2 directly interacts with the NudC protein and this interaction maintains its stability in the cytoplasm. Moreover, PCID2 is associated with the cytoplasmic mRNA and microtubules. The PCID2 knockdown blocks nuclear export of mRNA and also affects the general mRNA transport into the cytoplasm. These data suggest that PCID2 could be the link between the nuclear TREX-2-dependent export and the subsequent cytoplasmic trafficking of mRNA.Irritable Bowel Syndrome (IBS), the most common gastrointestinal disorder, is diagnosed solely on symptoms. Potentially diagnostic alterations in the bacterial component of the gut microbiome (the bacteriome) are associated with IBS, but despite the known role of the virome (particularly bacteriophages), in shaping the gut bacteriome, few studies have investigated the virome in IBS. We performed metagenomic sequencing of fecal Virus-Like Particles (VLPs) from 55 patients with IBS and 51 control individuals. We detected significantly lower alpha diversity of viral clusters comprising both known and novel viruses (viral 'dark matter') in IBS and a significant difference in beta diversity compared to controls, but not between IBS symptom subtypes. The three most abundant bacteriophage clusters belonged to the Siphoviridae, Myoviridae, and Podoviridae families (Order Caudovirales). A core virome (defined as a cluster present in at least 50% of samples) of 5 and 12 viral clusters was identified in IBS and control subjects, respectively. We also identified a subset of viral clusters that showed differential abundance between IBS and controls. The virome did not co-vary significantly with the bacteriome, with IBS clinical subtype, or with Bile Acid Malabsorption status. However, differences in the virome could be related back to the bacteriome as analysis of CRISPR spacers indicated that the virome alterations were at least partially related to the alterations in the bacteriome. We found no evidence for a shift from lytic to lysogenic replication of core viral clusters, a phenomenon reported for the gut virome of patients with Inflammatory Bowel Disease. Collectively, our data show alterations in the virome of patients with IBS, regardless of clinical subtype, which may facilitate development of new microbiome-based therapeutics.Integrating animals into therapy is applied increasingly in patients in a minimally conscious state (MCS). This pilot study investigates the effect of animal presence on frontal brain activity in MCS patients compared to healthy subjects. O2HB, HHb and tHb of two MCS patients and two healthy adults was measured in frontal cortex using functional near-infrared spectroscopy during three sessions with a live animal and three sessions with a mechanical toy animal present. Each session had five phases (1) baseline, (2) watching animal, (3) passive contact, (4) active contact, (5) neutral. Data were descriptively analysed. All participants showed the largest hemodynamic response during direct contact with the live or toy animal compared to "baseline" and "watching." During active contact, three of the four participants showed a stronger response when stroking the live compared to the toy animal. All participants showed an inverted signal with higher HHb than O2Hb concentrations while stroking the live or toy animal.