Kochlivingston6060
Oral squamous cell carcinoma (OSCC) is the most common malignancy of oral cavity and is commonly preceded by oral potentially malignant disorders. Glucose transporter-1 (GLUT-1) protein expression is upregulated in malignant cells that show increased glucose uptake. Alterations in GLUT-1 expression have been reported in several potentially malignant and malignant lesions.
The aims and objectives of this study were to analyze and assess the role of GLUT-1 immunomarker in oral epithelial dysplasia (OED) and OSCC, to demonstrate and analyze the presence, location and intensity of GLUT-1 immunomarker in low-risk and high-risk OEDs and in different grades of OSCC and to correlate the expression of GLUT-1 immunomarker between normal oral mucosa (NOM), OED and different grades of OSCC.
A total of ninety paraffin-embedded tissue blocks, 15 each of NOM; low-risk and high-risk OED and well, moderately and poorly differentiated OSCC were stained with the immunomarker GLUT-1.
GLUT-1 immunoexpression was statistically significant in terms of number of positive cells, staining intensity, IRS score and level of staining within the epithelium and also within the cell between NOM, OED and OSCC.
Increased GLUT-1 expression has a consistent role in the malignant transformation of OED and aggressiveness of OSCC.
Increased GLUT-1 expression has a consistent role in the malignant transformation of OED and aggressiveness of OSCC.
Macrophages account for 30%-50% of the total inflammatory cell population of tumor microenvironment that plays an important role in cancer metastasis. M2 macrophages are designated as tumor-associated macrophages (TAMs). They are known to orchestrate all the stages of tumor progression. CD163 is TAMs-M2-specific marker.
The aim of the study was to evaluate the role of TAMs using CD163 in different histological grades of oral squamous cell carcinoma (OSCC).
Expression of CD 163 was investigated in 30 histopthologically diagnosed cases of OSCC.
Two sections of 4-μ thickness were stained with hematoxylin and eosin, CD163 (Cell Marque, USA). The expression of TAMs with CD163-positive cells was done by counting the number of macrophages in three high-power fields (×400), and the mean number of macrophages per HPF was evaluated.
The statistical analysis was performed using Statistical Software SPSS version 20.0.
CD163 TAMs score increasing in higher tumor, node, metastasis stages with significant positive correlation.
With higher histological grades, CD163 TAMs score increased. Thus, TAMs may be considered as an independent factor for determining the progression of the tumor. The immunotherapeutic approaches to control M2 TAM numbers could protect against progression to malignancy.
With higher histological grades, CD163 TAMs score increased. Thus, TAMs may be considered as an independent factor for determining the progression of the tumor. The immunotherapeutic approaches to control M2 TAM numbers could protect against progression to malignancy.
Cemento-osseous dysplasia (COD) is a distinct entity, which is confined to the tooth-bearing areas of the jaws or edentulous alveolar processes.
This study analyzes the demographic, clinical, radiographic and histopathological features of COD.
Archival data from 2013 to 2017 present in the Department of Oral Pathology were retrieved. Clinicopathological and radiological features of all the cases which had been previously diagnosed as COD were analyzed in detail.
In the present study, 10 cases of COD were analyzed (1 periapical, 6 florid and 3 focal). Equal sex predilection was observed. The mean age in females and males was 42.6 years (22-64 years) and 28.6 years (17-36 years), respectively. learn more Bony expansion was seen frequently, but pain was not a common feature. Mandible was affected almost twice as frequently as maxilla and posterior region was affected more than anterior region. Most cases showed mixed radiopaque and radiolucent lesion (5/10) and peripheral radiolucent rim (9/10) on radiographic examtures is of paramount importance in the accurate diagnosis of COD.
Log odds of positive lymph nodes (LODDS) have been recently demonstrated as a very promising staging model and have outperformed AJCC pN, lymph node ratio (LNR) category in major cancers. Literature is scarce concerning the prognostic ability of LODDS in oral squamous cell carcinoma (OSCC) patients.
The present study was aimed to evaluate the importance of LODDS in predicting locoregional recurrence and overall survival (OS) in patients with OSCC compared to LNR.
The retrospective study was carried out on 194 patients with OSCC cases treated by surgery ± adjuvant therapy from 2008 to 2014 at our institution.
Demographical and clinicopathological details of study cases were recorded. LNR and LODDS were calculated and expressed as a percentage and mean ± standard deviation.
The OS analysis was done by the Kaplan-Meier curve followed by log-rank (mantel-cox) test. Univariate and multivariate survival analysis was done to analyze the prognostic ability of LNR% and LODDS after adjusting the clinicopathological parameters by the Cox proportional hazards model.
Patients with cut off values of LODDS >-1.2 and LNR% >4 had significantly lower mean OS (
≤ 0.001). Multivariate analysis indicated that only mean LODDS >-1.2 was significantly associated with poor OS. Although there was a correlation with locoregional recurrence, LODDS and LNR failed to be the independent predictors of locoregional recurrence.
LODDS was an independent reliable prognostic indicator for patients with OSCCs than conventional staging systems and LNR.
LODDS was an independent reliable prognostic indicator for patients with OSCCs than conventional staging systems and LNR.
The purpose of this study was to estimate hemoglobin (Hb) level, red cell indices (RCIs), serum iron level and Vitamin B12 level in patients with oral submucous fibrosis (OSMF) and to analyze the association of these parameters in different stages of OSMF.
This case-control study comprised of 65 individuals, with 40 OSMF patients and 25 controls. The OSMF patients were graded clinically according to the classification by Arakeri
. Fasting blood samples were collected from both groups for hematological evaluation.
The mean values and standard deviations were calculated by Chi-square test. Normality of various parameters was evaluated by Kolmogorov-Smirnov test. The independent
-test was used to compare more than two means simultaneously. Correlation analysis was done by Karl Pearson's correlation coefficient method.
The OSMF patients were in the age range of 21-67 years, with a mean age of 39.85 ± 10.42 years. The mean value of Hb of the control group was 14.24 ± 1.03 g/dL, whereas that of OSMF group was 11.
