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OBJECTIVE This study aimed to evaluate the effect of aspirin and pravastatin compared with aspirin on endothelin-1 levels, and the pregnancy outcome in pregnant women high risk for preeclampsia. METHODS It was a randomized clinical trial (RCT) analysis with block permutation. The sample divided into two groups. Group A as control has given aspirin 80mg and group B as an intervention group given aspirin 80mg plus pravastatin 20mg twice daily until 35 weeks gestation. Level of Endothelin-1 examined before and after treatment. RESULTS There no differences found in endothelin-1 levels before and after being treated with aspirin or aspirin and pravastatin, as well as in the umbilical artery resistance index, fetal biometry, and the development of the fetus in two groups was typical at 28-32 weeks' gestation. Similarly, no differences found in fetal outcomes such as preterm birth, fetal growth retardation, and the incidence of preeclampsia between the two groups. CONCLUSION As a conclusion, the administration of pravastatin, together with aspirin is no more effective than aspirin in preventing preeclampsia, to pregnancy outcome and decreasing endothelin-1 levels. No congenital abnormalities reported. OBJECTIVE To analyze the cement emission stacks dispersion using AERMOD and lung capacity of the surrounding society. METHOD The type of this research is spatial data analysis by using a cross-sectional study. The populations in this research are the eligible society that resides in radius less then 3km from cement industry area. The numbers of sample are 241 women living around of cement industry area with the cluster random sampling system. RESULT Body mass index (Sig 0.011), passive smokers (Sig 0.003), ambient air (Sig 0.000) and model of Stacks Dispersion emission in the morning and night using AERMOD indicates that parameter PM2,5, dust, NO2, SO2, and CO indicates that relationship phase toward society lung capacity. Analysis of bifilar logistic regression obtaining two variables that most determines toward respondent's lung are variable ambient air quality (p=0.000 and OR=5.565), passive smokers (p=0.013 and OR=2.028). Remdesivir CONCLUSION Stacks emission's dispersion possesses the air in the circle until the radius 3km. The ambient air and the passive smokers give the most significant effect on society's lung capacity condition which resides in the cement industry circle. OBJECTIVE This study aimed to find the role of Tamiang's local wisdom in decreasing postpartum depression a linguistic anthropology study. METHOD This research employed qualitative paradigm. As a qualitative research, it employed four methods of data collection, namely in-depth open-ended interview, direct participatory observation, focus group discussion which is often abbreviated as FGD and written documents. Data collected were analyzed by interactive model of Miles and Huberman. The focus of analysis is on performance, indexicality and participation as components of linguistic anthropology. RESULTS Tamiang's local wisdom in decreasing postpartum depression indexed in the process of Lepas dapur as a tradition to celebrate giving birth are thanksgiving, social loyalty and mutual cooperation. The role of Tamiang's local wisdom indicates that local wisdom can be used to decrease postpartum depression. One of five factors associated with postpartum depression is social risk factors. Its means that role of local wisdom is important to prevent the social risk factor and utilized to support being a mother without psychology's problems. CONCLUSION The role of Tamiang's local wisdom are used to decrease postpartum depression on social risk factors which are indexed in Tamiang Birth Tradition. L.U.OBJECTIVE This study aims to determine the description of prediabetes events in children based on socio-demographic, anthropometric, and lifestyle characteristics. METHOD This cross-sectional study involved 110 school-aged children and their parents. Physical Activity Questionnaire for Older Children (PAQ-C) was used to examine children's physical activity, HbA1c measured to evaluate diabetes status, and feeding behavior questionnaire is given to students and through interviews. RESULTS Prevalence of overweight and obese children who have an HbA1c level between 5.2% and 5.6% was 62.7%. Obese and overweight children are less support from family 72.2%, exercise once a week 82.7% with duration less than 60min 68.2%, the habit of snacking 64.5%, and consumption of fast food≥two times a week 62.7%. CONCLUSION Socio-demographic, cultural family, and lifestyle play a role in increasing the risk of incident prediabetes in overweight and obese children of school age. L.U.OBJECTIVE This study aimed to analyze the relationship between cortisol levels and labor outcomes among women in the third trimester of pregnancy. METHODS The design of this study was the Longitudinal Study. Data collected included age, education, parity, birth space, quality of Antenatal care, Antenatal Care frequency, socioeconomic factors, cortisol levels, and birth weight. The laboratory test for cortisol using ELISA plasma method with the categories of Normal cortisol levels (5-23 micrograms per deciliter (mcg/dL) or 138-635 nanomoles per liter (nmol/L) and High cortisol levels (>23 micrograms per deciliter (mcg/dL) or >635 nanomoles per liter (nmol/L). The samples were 55 third trimester pregnant women who had Antenatal Care and gave birth in the same place. The data were collected for three months by the researcher. The data analyzed using Mann-Whitney Test. RESULTS The results showed a p-value=0.000 (p less then 0.05) with the Mean Rank value at normal cortisol levels of 910.00, which was higher than the Mean Rank of high cortisol levels of 630.00. Thus, it can be concluded that there was a significant difference between the birth weight of babies with high cortisol levels and babies with normal cortisol levels among women in the third trimester of pregnancy with a different value of 27.5. CONCLUSION Cortisol levels in the third trimester of pregnancy associated with low birth weight (LBW) incidence. OBJECTIVE To analyze the comparison of the principles of hospital governance on the human resources performance at Regional General Hospital of Labuang Baji and Ibnu Sina. METHOD The type of research used was explanatory research. The population in this study were all employees in the general section of the Regional General Hospital of Labuang Baji and Ibnu Sina Hospital. The number of samples was 76 employees. The sampling technique used was exhaustive sampling. RESULTS Transparency (t 0.833; Sig 0.412), Accountability (t -0.680; Sig 0.502), and Independence (t -0.889; Sig 0.376) did no significantly affect, but Responsibility (t 2.676; Sig 0.012) and Fairness (t 2.412; Sig 0.022) significantly affected the performance in the Regional General Hospital of Labuang Baji. Meanwhile, in Ibnu Sina Hospital, transparency (t -0.539; Sig 0.594), responsibility (t 1.545; Sig 0.131) and independency (t -0.522; Sig 0.605) did not significantly affect, but accountability (t 1.919; Sig 0.063) and Fairness (t 1.755; Sig 0.088) fairness affected but not significant on the performance. CONCLUSION Responsibility and fairness were variable that affect the hospital governance on performance in the Regional General Hospital of Labuang Baji, while accountability and fairness affected but were not significant variables in Ibnu Sina Hospital. OBJECTIVE This study aimed to describe the values of local philosophy of nurse as a manifestation of improving the performance of nurses in Bima Regional General Hospital. METHODS The research used in this study was a qualitative method with a case study approach. Data were collected using in-depth interviews with nurses and hospital directors, and focus group discussion with nurses and supervisors. RESULT The results showed that the values of Local philosophy as a complex of ideas, norms, attitudes, communication, and regulations in the performance of nurses. However, the values of local philosophy were improving the performance of nurses Bima Regional General Hospital. Bima Regional General Hospital has implemented the values of local philosophy. Even though the hospital should make written regulation of local philosophy as a policy. Obviously, we cannot deny that the values of local philosophy greatly affect nurse performance then affect human behavior. CONCLUSION The values of Local philosophy as a complex of ideas, norms, attitudes, communication, and regulations in the performance of nurses. Basically, those values were derived from language as a form of verbal and nonverbal communication which were obtained from the history and social life of Bimanese. OBJECTIVE This study was aimed to describe the Makassar ethnic community's perception regarding pre-eclampsia in Gowa district. METHODS This study used a descriptive phenomenological design; the respondents were the Makassar ethnic community in the SombaOpu and Bajeng Primary Health Care. The study began in May until July 2019 with 36 informants using non-probability sampling technique. RESULTS People recognize as poisoning based on cultural perceptions adopted. For example, consuming shrimp, squid, crabs, moringa leaves, sitting in front of the door, and eating in bed. CONCLUSION Makassar ethnic perceptions about pre-eclampsia based on "taboo" or taboo during pregnancy. L.U.OBJECTIVE This research aimed to evaluate the interaction between polymorphisms of ERα & ERβ and associated with psychosocial stress on menopausal women. METHODS It was a cross-sectional study, subject were 102 women aged 40-70 years who meet the inclusion criteria at the Obstetrics and Gynecology Education Hospital of Hasanuddin who agreed on filling questioner which have been determined. Then proceed with blood taking for the ERα and ERβ receptor polymorphisms. Genomic DNA was isolated from 1mL of EDTA anticoagulation edge blood sample using a salting-out procedure and examined interaction of polymorphisms receptors ERα and ERβ. The data were statistically analyzed using the chi-square test with p-value less then 0.05. RESULTS This research showed that subjects who experienced psychosocial stress have the most ERα Pvull heterozygous Pp polymorphism, ERα Xbal homozygous recessive xx, and homozygous dominant ERβ AA. There is ERβ polymorphism relationship with the occurrence of psychosocial stress in menopausal women. But there is no relationship between polymorphisms ERα Pvull, ERα Xbal, as well as the interaction between polymorphisms of ERα and ERβ with the occurrence of psychosocial stress in menopausal women. CONCLUSION ERβ polymorphism relationship the occurrence of psychosocial stress in menopausal women. OBJECTIVE The purpose of this study was to identify the Determinants of Stunting in children aged 25-60 months in Majene Regency. METHOD This research applied observational analytic with cross sectional approach. The population is all children under five aged 25-60 months in Majene Regency with a total sample of 573 respondents, using cluster random sampling to select villages. RESULTS The results of bivariate analysis conducted by Chi square test statistical tests obtained that have a significant relationship with the incidence of stunting are age of eating fish, high maternal body and giving colostrum, namely p 0.05 (0.0001, 0.003 and 0.047). CONCLUSION The results of multivariate logistic regression analysis concluded that the most influential variable on the occurrence of stunting was the age at which fish began to eat.