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Source code is the heart of the software systems; it holds a wealth of knowledge that can be tapped for intelligent software systems and leverage the possibilities of reuse of the software. In this work, exploration revolves around making use of the pattern hidden in various software development processes and artifacts. This module is part of the smart requirements management system that is intended to be built. This system will have multiple modules to make the software requirements management phase more secure from vulnerabilities. Some of the critical challenges bothering the software development community are discussed. The background of Machine Learning approaches and their application in software development practices are explored. Some of the work done around modeling the source code and approaches used for vulnerabilities understanding in software systems are reviewed. Program representation is explored to understand some of the principles that would help in understanding the subject well. Further deeper dive into source code modeling possibilities are explored. Machine learning best practices are explored inline with the software source code modeling.In the paper, under the stress of aggregation and reproduction mechanism of algae, we proposed a modified algae and fish model with aggregation and Allee effect, its main purpose was to further ascertain the dynamic relationship between algae and fish. Several critical conditions were investigated to guarantee the existence and stabilization of all possible equilibrium points, and ensure that the model could undergo transcritical bifurcation, saddle-node bifurcation, Hopf bifurcation and B-T bifurcation. Numerical simulation results of related bifurcation dynamics were provided to verify the feasibility of theoretical derivation, and visually demonstrate the changing trend of the dynamic relationship. Our results generalized and improved some known results, and showed that the aggregation and Allee effect played a vital role in the dynamic relationship between algae and fish.In this paper, we present a multi-scale co-affection model of HIV infection and opioid addiction. The population scale epidemiological model is linked to the within-host model which describes the HIV and opioid dynamics in a co-affected individual. CD4 cells and viral load data obtained from morphine addicted SIV-infected monkeys are used to validate the within-host model. AIDS diagnoses, HIV death and opioid mortality data are used to fit the between-host model. When the rates of viral clearance and morphine uptake are fixed, the within-host model is structurally identifiable. If in addition the morphine saturation and clearance rates are also fixed the model becomes practical identifiable. Analytical results of the multi-scale model suggest that in addition to the disease-addiction-free equilibrium, there is a unique HIV-only and opioid-only equilibrium. Each of the boundary equilibria is stable if the invasion number of the other epidemic is below one. Elasticity analysis suggests that the most sensitive number is the invasion number of opioid epidemic with respect to the parameter of enhancement of HIV infection of opioid-affected individual. We conclude that the most effective control strategy is to prevent opioid addicted individuals from getting HIV, and to treat the opioid addiction directly and independently from HIV.Cardiovascular disease is one of the most challenging diseases in middle-aged and older people, which causes high mortality. Coronary artery disease (CAD) is known as a common cardiovascular disease. A standard clinical tool for diagnosing CAD is angiography. The main challenges are dangerous side effects and high angiography costs. Today, the development of artificial intelligence-based methods is a valuable achievement for diagnosing disease. Hence, in this paper, artificial intelligence methods such as neural network (NN), deep neural network (DNN), and fuzzy C-means clustering combined with deep neural network (FCM-DNN) are developed for diagnosing CAD on a cardiac magnetic resonance imaging (CMRI) dataset. The original dataset is used in two different approaches. First, the labeled dataset is applied to the NN and DNN to create the NN and DNN models. Second, the labels are removed, and the unlabeled dataset is clustered via the FCM method, and then, the clustered dataset is fed to the DNN to create the FCM-DNN model. By utilizing the second clustering and modeling, the training process is improved, and consequently, the accuracy is increased. As a result, the proposed FCM-DNN model achieves the best performance with a 99.91% accuracy specifying 10 clusters, i.e., 5 clusters for healthy subjects and 5 clusters for sick subjects, through the 10-fold cross-validation technique compared to the NN and DNN models reaching the accuracies of 92.18% and 99.63%, respectively. To the best of our knowledge, no study has been conducted for CAD diagnosis on the CMRI dataset using artificial intelligence methods. The results confirm that the proposed FCM-DNN model can be helpful for scientific and research centers.Diabetes is a metabolic disorder caused by insufficient insulin secretion and insulin secretion disorders. From health to diabetes, there are generally three stages health, pre-diabetes and type 2 diabetes. Early diagnosis of diabetes is the most effective way to prevent and control diabetes and its complications. In this work, we collected the physical examination data from Beijing Physical Examination Center from January 2006 to December 2017, and divided the population into three groups according to the WHO (1999) Diabetes Diagnostic Standards normal fasting plasma glucose (NFG) (FPG 7.0 mmol/L). Finally, we obtained1,221,598 NFG samples, 285,965 IFG samples and 387,076 T2DM samples, with a total of 15 physical examination indexes. Furthermore, taking eXtreme Gradient Boosting (XGBoost), random forest (RF), Logistic Regression (LR), and Fully connected neural network (FCN) as classifiers, four models were constructed to distinguish NFG, IFG and T2DM. The comparison results show that XGBoost has the best performance, with AUC (macro) of 0.7874 and AUC (micro) of 0.8633. In addition, based on the XGBoost classifier, three binary classification models were also established to discriminate NFG from IFG, NFG from T2DM, IFG from T2DM. On the independent dataset, the AUCs were 0.7808, 0.8687, 0.7067, respectively. Finally, we analyzed the importance of the features and identified the risk factors associated with diabetes.In this work, we report a large-scale synchronized replacement pattern of the Alpha (B.1.1.7) variant by the Delta (B.1.617.2) variant of SARS-COV-2. We argue that this phenomenon is associated with the invasion timing and the transmissibility advantage of the Delta (B.1.617.2) variant. Alpha (B.1.1.7) variant skipped some countries/regions, e.g. India and neighboring countries/regions, which could have led to a mild first wave before the invasion of the Delta (B.1.617.2) variant, in term of reported COVID-deaths per capita.The use of the SEIR model of compartmentalized population dynamics with an added fomite term is analysed as a means of statistically quantifying the contribution of contaminated fomites to the spread of a viral epidemic. JAK inhibitor It is shown that for normally expected lifetimes of a virus on fomites, the dynamics of the populations are nearly indistinguishable from the case without fomites. With additional information, such as the change in social contacts following a lockdown, however, it is shown that, under the assumption that the reproduction number for direct infection is proportional to the number of social contacts, the population dynamics may be used to place meaningful statistical constraints on the role of fomites that are not affected by the lockdown. The case of the Spring 2020 UK lockdown in response to COVID-19 is presented as an illustration. An upper limit is found on the transmission rate by contaminated fomites of fewer than 1 in 30 per day per infectious person (95% CL) when social contact information is taken into account. Applied to postal deliveries and food packaging, the upper limit on the contaminated fomite transmission rate corresponds to a probability below 1 in 70 (95% CL) that a contaminated fomite transmits the infection. The method presented here may be helpful for guiding health policy over the contribution of some fomites to the spread of infection in other epidemics until more complete risk assessments based on mechanistic modelling or epidemiological investigations may be completed.Many real world problems depict processes following crossover behaviours. Modelling processes following crossover behaviors have been a great challenge to mankind. Indeed real world problems following crossover from Markovian to randomness processes have been observed in many scenarios, for example in epidemiology with spread of infectious diseases and even some chaos. Deterministic and stochastic methods have been developed independently to develop the future state of the system and randomness respectively. Very recently, Atangana and Seda introduced a new concept called piecewise differentiation and integration, this approach helps to capture processes with crossover effects. In this paper, an example of piecewise modelling is presented with illustration to chaos problems. Some important analysis including a piecewise existence and uniqueness and piecewise numerical scheme are presented. Numerical simulations are performed for different cases.In the context of the theory of multi-agent systems, the shepherding problem refers to designing the dynamics of a herding agent, called a sheepdog, so that a given flock of agents, called sheep, is guided into a goal region. Although several effective methodologies and algorithms have been proposed in the last decade for the shepherding problem under various formulations, little research has been directed to the practically important case in which the flock contains sheep agents unresponsive to the sheepdog agent. To fill in this gap, we propose a sheepdog algorithm for guiding unresponsive sheep in this paper. In the algorithm, the sheepdog iteratively applies an existing shepherding algorithm, the farthest-agent targeting algorithm, while dynamically switching its destination. This procedure achieves the incremental growth of a controllable flock, which finally enables the sheepdog to guide the entire flock into the goal region. Furthermore, we illustrate by numerical simulations that the proposed algorithm can outperform the farthest-agent targeting algorithm.This paper studies the nonlinear vibrating behaviour of a nonlinear cantilever beam system (primary system) using a nonlinear absorber (the secondary system). The nonlinear vibrating behavior for the present dynamical system is considered with the effect of the external force. The one controller type, nonlinear saturation controller (NSC), is introduced to decrease the vibration of this system. Perturbation method treatment is produced to get the mathematical solution of the equations for the dynamical modeling with NSC. The perturbation technique is used to obtain the approximate solution of the dynamical system. This research focuses on resonance case with primary and 12 internal resonance. Time histories of the primary system and the controller are shown to demonstrate the reaction with and without control. The time-history response, as well as the impacts of the parameters on the system and controller, are simulated numerically using the MATLAB program. Routh-Hurwitz criterion is used to examine the stability of the system under primary resonance.

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