Kringcaspersen1169

05 (0.97-1.13) for upper-middle, 1.05 (0.98-1.13) for lower-middle, and 1.10 (1.03-1.18) for low. The same tendency was observed in K6 cases.

Depressive state was identified by self-administered questionnaire.

Lower social support during pregnancy is associated with increased counterfactual risk of perinatal/postpartum depressive state and worsened counterfactual spontaneous recovery over time. These findings highlight the importance of sufficient social support for preventing perinatal/postpartum depression and promoting recovery.

UMIN000030786.

UMIN000030786.Background Despite progress in youth anxiety assessment, there is need for a measure that is simultaneously (a) free, (b) brief, (c) focused broadly on anxiety and avoidance severity, frequency, and interference, and (d) concerned with the past week. The adult overall anxiety severity and impairment scale (OASIS) was adapted to yield a caregiver-report of past week youth anxiety and interference (OASIS-Y). Methods In a sample of diverse youth seeking anxiety services (N = 132; 67% racial/ethnic minority) and their caregivers, analyses examined the OASIS-Y factor structure, internal consistency, and convergent and divergent validity. Hierarchical linear modeling in a participant subset examined OASIS-Y sensitivity to treatment-related change. Results OASIS-Y internal consistency was high and confirmatory factor analysis supported a single-factor structure similar to that found in adults. OASIS-Y convergent validity was supported by a medium-sized association with an established, commercially available measure of youth anxiety, and divergent validity was supported by the absence of unique associations with measures of youth attention and externalizing problems. Lithocholic acid concentration In a sample subset, session-by-session OASIS-Y scores significantly declined across treatment, and declined at a steeper rate among treatment "responders" versus "non-responders," providing evidence of OASIS-Y sensitivity to treatment-related change. Limitations This study focused on a clinical sample and cannot speak to OASIS-Y performance in community settings. Shared method-variance may have also influenced findings. Conclusions This study offers the first psychometric evaluation of the OASIS-Y, and underscores the promising clinical utility of the measure for assessing past week youth anxiety and impairment and for supporting routine outcome monitoring.

Brain white matter (WM) abnormalities are biomarkers that seem to be involved in bipolar disorder (BD) aetiology and maintenance. Evidences suggest a possible association between neurodegeneration, neuroaxonal alterations and BD. A biomarker that is recently drawing attention is neurofilaments light (NfL) chain, a cytoskeletal intermediate filament protein expressed in neurons. To investigate neuroimaging alterations associated with BD, we studied the association between NfL levels and WM microstructure.

NfL plasma quantification was performed in a sample of 45 depressed BD patients compared with 29 healthy controls (HC) using Quanterix SIMOA assay. Statistical analysis were conducted to evaluate NfL levels differences between BD patients and controls. Analyses of the diffusion data were performed using Tract Based Spatial Statistics (TBSS) on Diffusion Tensor images acquired using a 3.0 Tesla MR scanner.

Patients had higher NfL levels than HC (9.13±4.78vs 4.28±2.39 pg/ml; p<0.001). The separate-slopgeneration.

Several prospective studies have identified that hypertension is an important risk factor of post-stroke depression (PSD). However, the effect of immediate antihypertensive treatment on the risk of PSD in patients with acute ischemic stroke remains unknown.

In this prespecified depression substudy of the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) randomized clinical trial, a total of 642 patients with acute ischemic stroke within 48h of onset and elevated systolic BP at 7 sites of CATIS were included. Patients were randomly assigned to receive antihypertensive treatment (n=318) or to control group (n=324). The primary outcome was depression (Hamilton Rating Scale for Depression score≥8) at 3-month posttreatment follow-up.

At 24h after randomization, the mean systolic BP was reduced by 21.6mm Hg (12.5%) in the treatment group and 13.9mm Hg (7.9%) in the control group (difference, -7.7mm Hg [95% CI, -10.2 to -5.2]; P<0.001). The mean systolic BP levels at 7 days (P<0.001) and 14 days (P<0.001) after randomization in treatment group were also significantly lower than those in control group. At 3-month posttreatment follow-up, 122 patients (38.4%) in antihypertensive treatment group and 131 patients (40.4%) in control group developed PSD (odds ratio, 0.92 [95% CI, 0.67 to 1.26]; P=0.59).

All patients in the CATIS trial were Chinese, which might limit the generalizability of our findings to other populations.

Early antihypertensive treatment had no effect on the risk of PSD at 3 months among patients with acute ischemic stroke and elevated BP.

Early antihypertensive treatment had no effect on the risk of PSD at 3 months among patients with acute ischemic stroke and elevated BP.

The purpose of this study was to provide an operating mechanism for understanding the effects of COVID-19's on satisfaction with life, subject to students' general mental health METHODS A sample of 1653 Greek speaking university students (72.4% females, 65.3% undergraduate, M age=26.1) completed an online survey including measures for perceived psychological, academic, and financial impact of the COVID-19 pandemic, general mental health and satisfaction with life.

A mediation model was tested to illuminate these relationships by considering students' general mental health as a mediator. Findings demonstrated that there were significant direct effects of perceived COVID-19 impact on participants' financial status on satisfaction with life and indirect effects of perceived COVID-19 impact on participants' financial status and academic performance respectively on satisfaction with life through general mental health.

The study's cross-sectional design, self-report data and snowball sampling.

The findings add to our understanding of the relationship between perceived COVID-19 impact and life satisfaction among university students, and they shed light on the critical role of general mental health in mediating the relationship. Targeting the factors that influence general mental health can help to mitigate potential problems while also finding ways to improve mental health and well-being.

The findings add to our understanding of the relationship between perceived COVID-19 impact and life satisfaction among university students, and they shed light on the critical role of general mental health in mediating the relationship. Targeting the factors that influence general mental health can help to mitigate potential problems while also finding ways to improve mental health and well-being.

Although the benefits of exercise on Major Depressive Disorder (MDD) are well established, longitudinal studies of objectively measured activity in clinical populations are needed to establish specific guidelines for exercise by persons with moderate-to-severe depression. This study examines the association between objectively assessed daily step count and depressive symptoms over a 24-week follow- up period in outpatients receiving treatment for moderate-to-severe depression.

Participants were US Veterans with MDD enrolled in the Precision Medicine in Mental Health Care study (PRIME Care), a pragmatic, multi-site, randomized, controlled trial that examines the utility of genetic testing in the context of pharmacotherapy for MDD. Participants were a subset (N=66) enrolled in actigraphy (using GT9X ActiGraph) monitoring component of the trial. Daily steps were examined as a predictor of depressive symptoms over 4-, 8-, 12-, 18-, and 24-weeks.

On average, participants took 3,460 (±1,768) steps per day. In generalized linear mixed models, an increase in 1,000 steps per day was associated with a 0.6-point decrease in depressive symptom severity at the subsequent follow-up assessment.

Activity monitoring was observational and causal inferences cannot be made between daily steps and subsequent depressive symptom severity. Results may not generalize to non-treatment-seeking populations.

Study findings provide an initial metric for persons with clinically significant MDD, of whom most do not get sufficient daily activity. The findings can inform future trials aimed at determining how much daily activity is needed to improve symptoms in individuals with MDD.

Study findings provide an initial metric for persons with clinically significant MDD, of whom most do not get sufficient daily activity. The findings can inform future trials aimed at determining how much daily activity is needed to improve symptoms in individuals with MDD.This study examined the relationships between self-reported and behavioral authoritative parenting practices and indicators of healthy and unhealthy eating in a sample of 29 families with a child 3-5 years of age (14 Latinx families, 15 White-European families). This study used self-report measures and an innovative audio recording device to track caregiver-child interactions in natural environments. Main findings of this study include that Latinx caregivers compared to White-European caregivers were less warm and less likely to encourage their children to eat, both at the behavioral level and the caregiver-report level. In the case of Latinx caregivers only, behavioral praise and warmth were related to lower consumption of sweets and sweetened beverages. Taken together, the findings of this study offer valuable insights into the nature of authoritative food parenting in naturalistic settings. link2 Findings and implications for culturally relevant interventions are discussed.Breastfeeding has been associated with improved growth, development, and health outcomes for infants and children. However, the exclusive breastfeeding rate in Indonesia is suboptimal (37%). There is limited contextualised understanding of mothers' perceptions of breastfeeding and the factors behind exclusive breastfeeding practices. The aim of this qualitative study was to compare breastfeeding perceptions and exclusive breastfeeding practices between rural and urban mothers. We conducted a qualitative comparative study through in-depth interviews with 46 caregivers of children aged 6-23 months, two health professionals, and ten kader (frontline female health workers at the village level) in Central Java, Indonesia. We analysed the data using thematic analysis. Urban mothers had better knowledge and perceptions of breastfeeding and more access to breastfeeding information sources. However, exclusive breastfeeding practice was more frequent among rural mothers. link3 Family and healthcare workers acted as both facilitators and barriers to exclusive breastfeeding practice in both settings. Perceptions of insufficient breast milk supply, infant illness, and breast problems prevented rural and urban mothers to breastfeed exclusively. Mother-infant separation after birth, breast rejection, latching difficulty, and maternal employment were among the factors that caused urban mothers to discontinue breastfeeding exclusively. Breastfeeding promotion strategies should focus on enhancing maternal breastfeeding knowledge and problem-solving skills by considering the individual and social context, particularly in urban areas where exclusive breastfeeding obstacles are more nuanced.