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From this study, we first clarified pathogenic regulatory role of polymorphic SERPINA3 in neurodegeneration.

To investigate the comparative efficacy of intense pulsed light (IPL) therapy alone with that of IPL plus meibomian gland expression (MGX) for meibomian gland dysfunction (MGD).

This is a prospective randomized crossover clinical trial. Sixty patients were enrolled and randomly assigned to two groups. All of patients underwent four treatment sessions in total, which were two weeks apart. Group 1 underwent two sessions of IPL therapy with MGX, as well as two sessions of IPL alone. Group 2 received two sessions of IPL therapy alone, and two sessions of IPL therapy with MGX. The following parameters were measured at baseline (BL), 2 weeks after the second treatment session (FU1), and 2 weeks after the fourth treatment session (FU2) tearfilm break-up time (BUT), Oxford grade for corneal staining, meibomian gland expressibility (MGE), meibum quality (MQ), and ocular surface disease index (OSDI). The separate effect of MGX on improvement of MGD parameters was evaluated using generalized estimating equation (GEErapy. The meibomian gland function (MGE and MQ) recovers faster in response to IPL therapy than did the other parameters.

IPL therapy effectively improves the subjective symptoms and objective ocular findings of MGD. MGX enhanced the improvement of BUT driven by IPL therapy. The meibomian gland function (MGE and MQ) recovers faster in response to IPL therapy than did the other parameters.This study aimed to identify factors affecting the occurrence of intimate partner violence (IPV) in Korean adults aged 19 years and older. Specifically, we identified the factors in women's victimization in and men's perpetration of IPV. This study adopted a cross-sectional and correlational design in conducting secondary data analysis of the 2016 Domestic Violence Survey in Korea. Men (N = 1,272) and women (N = 2,689) with partner were included in the analysis. The ecological model was used as a conceptual framework. Multiple logistic regression analyses were conducted to identify factors affecting women's victimization in and men's perpetration of IPV. The results showed that the prevalence of IPV against female partner was 12.1%. IPV occurrence was higher among women (Odds ratios (OR) = 2.92, Confidence intervals (CI) 1.84-4.63) and men (OR = 2.64, CI 1.62-4.32) who experienced witnessing inter-parental violence in childhood, and among women (OR = 2.25, CI 1.40-3.61) and men (OR = 2.68, CI 1.59-4.52) with a tolerant attitude toward IPV. The occurrence was higher among women who experienced childhood maltreatment by the parents (OR = 1.70, CI 1.03-2.82) and women whose income was 2 million Korean Won(KRW) to 3 million KRW compared with women whose income was above 4 million KRW (OR = 1.97, CI 1.10-3.55). The occurrence was lower among women with office jobs compared with other jobs (OR = 0.47, CI 0.26-0.84). Based on the results of this study, early intervention in abusive families to reduce the negative impact of abuse experiences and witnessing inter-parental violence in childhood, and education and publicity for changing attitudes toward IPV are necessary at the individual and societal levels. The formation of policies for the stable workplace and income of women are required.COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twenty-one substitutions that have frequencies greater than 3% of viral population were identified. Analysis of these substitutions indicated that P1427I (ORF1b), Y1464C (ORF1b), and Q57H (ORF3a) might affect functions of the corresponding SARS-CoV-2 encoded proteins. Additionally, we found the evidence of positive selection on the ORF3a and codon 614 of Spike protein, suggesting the viral components responsible for host entry and activation of inflammation response were targeted by host immune responses. The study showed genomic variation and evolution of SARS-CoV-2 in a Canadian population. These information may help develop preventive strategies and be used for further study of SARS-CoV-2 pathogenesis and therapeutics development.

To describe how men and women divided childcare and housework demands during the height of the first Covid-19 lockdown in the UK, and whether these divisions were associated with worsening mental health during the pandemic.

School closures and homeworking during the Covid-19 crisis have resulted in an immediate increase in unpaid care work, which draws new attention to gender inequality in divisions of unpaid care work.

Data come from the wave 9 (2017-19) of Understanding Society and the following April (n = 15,426) and May (n = 14,150) waves of Understanding Society Covid-19 study. Psychological distress was measured using the General Health Questionnaire (GHQ) at both before and during the lockdown, and unpaid care work was measured during the lockdown. MK-0159 inhibitor Linear regression models were used.

Women spent much more time on unpaid care work than men during lockdown, and it was more likely to be the mother than the father who reduced working hours or changed employment schedules due to increased time on chhers.[This corrects the article DOI 10.1371/journal.pone.0232487.].

Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes coronavirus disease (COVID-19), is creating an unprecedented burden on health care systems across the world due to its high rate of pneumonia-related hospitalizations. This study presents recommendations for the outpatient management of moderate SARS-CoV-2 pneumonia implemented at the Geneva University Hospital, Switzerland, from April 4 to June 30, 2020 and evaluated the impact of these recommendations on patient safety, patient satisfaction, and overall hospital capacity.

Recommendations for the outpatient management of moderate pneumonia implemented in the Geneva University Hospital (PneumoCoV-Ambu) between April 4 and June 30, 2020, were evaluated prospectively. The primary endpoint was hospitalization. Secondary endpoints were severity of COVID-19 disease based on a 7-points ordinal scale assessed at 1 and 2 months following SARS-CoV-2 infection; patient satisfaction using a satisfaction survey and the analysis of number of beds and costs potentially averted.