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There is no standard treatment strategy for the third-line and above treatment of advanced nonsmall cell lung cancer (NSCLC). This study aimed to investigate the effects of anlotinib in patients with NSCLC. Data was collected from a group of advanced lung cancer patients who received anlotinib as a third-line or post-third-line treatment between 2017 and 2019. The Kaplan-Meier method was used to calculate the progression-free survival (PFS) of these lung cancer patients treated with anlotinib. Univariate analysis was performed using the log-rank test. Forest plot was used for subgroup analysis.Our study included 44 patients. Oral anlotinib was used as a third-line treatment to treat 26 patients, and as a fourth-line or multiline treatment in 18 patients. The objective control rate was 5%, the disease control rate was 89%, and the median PFS was 4.0 months with a 95% confidence interval. Common toxicities included anorexia, hypertension, and fatigue. this website Anlotinib demonstrated promising efficacy and was well tolerated with controlled toxicity in patients with NSCLC.Many LGBTQ film festivals have transformed from bottom-up, community-driven events into established, profitable organizations. For some, this change has implied downplaying their activist agenda in favor of a celebratory and homonormative approach. This article demonstrates how BFI Flare London LGBT Film Festival, a long-running European LGBTQ film festival, has dealt with the turn to homonormativity. Reporting on a qualitative study on the role of programmers and the actual program during BFI Flare's 30th edition, this article argues that BFI Flare employs programming strategies that are moderately queer. These strategies are used to produce a festival that is both politically engaging and commercially viable, curating a program that is considered as inclusive as possible, attractive to large and heterogeneous audiences, and as striking a balance between celebrating LGBTQ (film) culture and engendering social and political change.To determine the occurrence of mineral oil hydrocarbons (MOH) in food contact papers in China, and to investigate the potential sources of MOH contamination, a total of 159 food contact papers and raw materials were analysed by off-line solid-phase extraction-gas chromatography flame ionisation detection (SPE-GC-FID) and a GC-MS method. The migration of MOH from food contact papers into Tenax, olive oil or 50% ethanol under the worst foreseeable conditions of use was determined. The results indicated that the occurrence of MOH in China is of a potential health risk concerning the migration of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) which were detected in 82.6% and 50.4% of samples, respectively. Migration of MOSH from 47.9% of samples was higher than 2 mg/kg and migration of MOAH from 32.2% samples exceeded 0.5 mg/kg in case of the worst foreseeable condition of use. The highest mean migration of MOSH and MOAH were found in packaging papers for long-term storage (more than 6 months), with mean migration of 91.2 mg/kg and 1.4 mg/kg, respectively. Migration of MOH from printed paper was considerably higher than that of unprinted paper, validating previous findings that the printing ink is the predominant source of MOH contamination in food contact papers. Migration of MOH from paper bowls used for packing instant noodles was relatively low, suggesting the internal hollow layer may be acting as a functional barrier that could block the transfer of MOH (up to C28) through the gas phrase, even though the outer layer was made from recycled paper. High concentrations of MOSH and MOAH were also detected in de-foamers, adhesives and rosin sizing agents, indicating that the MOH contamination caused by the use of raw materials and additives should also be taken into consideration.This article explores how young gay men who are involve in Lima's middle-class gay scene made sense of their intimate relationships regarding discourses about sexuality, intimacy, and love. Drawing on in-depth interviews with 14 such men, I found that diverse and seemingly conflicting discursive configurations coexisted and intertwined within aspects of their relationships such as monogamy, sex-role positioning, and interpretations of sexual intimacy. Although participants mostly endorsed "modern" categories, more attuned with global messages of gender equality and egalitarianism, they also combined them with discourses that were more "traditional"-gendered and related to romantic love. Participants negotiated these tensions through a pattern of reflexive and unreflexive (dis)identifications, which were embedded in structural socioeconomic conditions. These findings acknowledge the complexities of Latin American middle-class gay sexualities and challenge rigid models of same-sex desire, as well as arguments about the exceptionally reflexive qualities of "modern" gay identities.

This study aims to investigate the efficacy of different types of physiotherapy approaches in individuals with cervical myofascial painful temporomandibular disorders (TMDs).

Seventy-five participants with myofascial pain of jaw muscles and cervical myofascial pain were randomized into three groups exercise group (E), low-level laser therapy group (LLLT), and manual pressure release group (MPR). All patients were assessed before treatment and after 12 sessions of treatment.

Significant improvement was seen in all groups' pressure pain threshold (PPT) values (

<0.01). Some masticatory and neck muscles' PPT changes in MRP and LLLT groups were significantly higher than the exercise group (

<0.05).

Exercise therapy is an effective approach for treatment of TMDs. Additionally, LLLT combined with exercise and MPR combined with exercise have better effects than only exercise therapy. Multimodal treatment approaches should include exercise to achieve better results in clinical practice.

Exercise therapy is an effective approach for treatment of TMDs. Additionally, LLLT combined with exercise and MPR combined with exercise have better effects than only exercise therapy. Multimodal treatment approaches should include exercise to achieve better results in clinical practice.