Hongsun6177
Our results provide an insight into the ecological and biogeochemical impact of viruses oxygen-depleted and euxinic habitats.Activation of microglia and the subsequently elevated inflammatory cytokine release in the brain during surgery predispose individuals to cognitive dysfunction, also known as postoperative cognitive dysfunction (POCD). miR-124 is one of the most abundant microRNAs in the brain that regulates microglial function. Elucidating the role of miR-124 in microglial activation in the context of surgery may therefore promote understanding of as well as therapeutic development for post-surgical disorders involving microglial activation. The downstream targets of miR-124 were investigated using bioinformatic screening and dual-luciferase reporter assay validation, and vesicle-associated membrane protein 3 (VAMP3) was identified as a potential target. The kinetics of miR-124/VAMP3 expression was first examined in vitro in microglial cells (primary microglia and BV2 microglial cells) following lipopolysaccharide (LPS) stimulation. LPS induced a time-dependent decrease of miR-124 and upregulated the expression of VAMP3. Man24/VAMP3 is involved in surgery-induced microglial activation and that targeting miR-124/VAMP3 could be a potential therapeutic strategy for postoperative disorders involving microglial activation.
There are few studies of nutritional and genetic factors and their interactions on the risk of noncommunicable diseases (NCDs) among Chinese adults.
Our aim for the Nutrition and Health in Southwest China (NHSC) study is to investigate the impact of diet, lifestyle, genetic background, and their interactions on NCDs among adults in Southwest China.
The NSHC is a prospective cohort study initiated in winter 2013. The baseline data collection was completed in December 2018, and follow-ups are conducted every 2 years. Information on genomics, anthropometry, nutrition, eating behaviors, physical activity, depression and mental disorders, clinical and biochemical examinations, and lifestyles was collected.
7926 adults completed the baseline questionnaire. The average age of participants was 42.6 (9.8) years at study enrollment. More than half were female, 37.2% had achieved more than 12 years of education, and 49.3% of them came from family income >35,000 Yuan. Our analyses of the baseline data suggested that adults with greater dietary energy density appeared to have greater body mass index, fat mass index, fat-free mass index and percentage body fat, and that participants with a higher level of dietary glycemic index, glycemic load, or serum 25(OH)D had a less favorable glucose homeostasis. In addition, spending less time watching television and having a healthy eating pattern may play significant roles in later cellular aging.
In conclusion, the NHSC cohort provides valuable data for investigations of the relevance of gene, nutrition, lifestyles, and their interactions on NCDs among southwestern Chinese adults.
In conclusion, the NHSC cohort provides valuable data for investigations of the relevance of gene, nutrition, lifestyles, and their interactions on NCDs among southwestern Chinese adults.
Childhood rapid growth and earlier puberty onset have been associated with adult obesity. However, the association between childhood stunting, pubertal timing and adult obesity is unclear. We examined whether the relationship between stunting at age 2 years (y) and body composition at 23 years is mediated by adolescent body mass index, and pubertal development, using the Birth-to-Twenty Plus cohort (South Africa).
For 1036 participants, data on anthropometrics between birth and 23 years, maternal factors, and pubertal development (Tanner scale at 9-16 years) were collected. Stunting at 2 years (height-for-age z-score < -2), 5-18 years BMI-for-age trajectories, pubertal development trajectories, and DXA-derived fat mass (FM) and fat free mass (FFM) at 23 years were determined. Data were analysed using hierarchical regressions and structural equation models.
Stunting was directly associated with slower pubertal development and with shorter adult stature, but was not associated with adolescent BMI trajectories, adult FM or FFM. However, stunting was indirectly associated with adult FM and FFM through the direct associations between slower pubertal development and lower FM and between shorter height and lower FFM. BMI trajectories were independently associated with FM and FFM.
Being stunted in this population predicted adult body composition through slower pubertal development and shorter adult stature.
Being stunted in this population predicted adult body composition through slower pubertal development and shorter adult stature.Obesity is defined as an abnormal/excessive accumulation of body fat, associated with health consequences. find more Although overall obesity does confer a significant threat to the health of individuals, the distribution of body fat, especially abdominal/central obesity is of greater importance. For practical reasons, proxy anthropometric measurements have been developed to identify central obesity, however, major limitations are noted in these traditional measurements. The present study aims to evaluate the literature, to identify and describe non-traditional anthropometric measurements of overweight and obesity in children. The current systematic review was conducted in accordance with the PRISMA guidelines, and the search was undertaken in the PubMed® database, using MeSH (Medical Subject Headings) terms. Data extracted from each study were (a) details of the study, (b) anthropometric parameter(s) evaluated in the study and its details, (c) study methods, (d) objectives of the study and/or comparisons, and (e) main findings/conclusions of the study. The search yielded a total of 3697 articles, of which 31 studies were deemed eligible to be included. The literature search identified 13 non-traditional anthropometric parameters. Data on non-traditional anthropometric parameters were derived from 24 countries. Majority were descriptive cross-sectional studies (n = 29), while sample size varied from 65 to 23,043. Non-traditional anthropometric parameters showed variable correlation with obesity and/or related metabolic risk factors. Some parameters involved complex calculations, while others were based on a single anthropometric measurement or derived from traditional measures. Most studies lacked comparison with a 'gold standard' assessment of body fat, hence further research is required to determine their accuracy and precision.
