Bowmannoel4033

Evidence-based research and interventions to address systemic institutional racism have never been more urgent. Yet, underrepresented minority (URM) professionals in research institutions who primarily produce that evidence have remained abysmally low for decades. This unique study of URM university professors assesses factors-vocational strain, role overload, discrimination, coping strategies-that contribute to health and well-being, research productivity, and ultimately their retention in high impact research positions. We administered a web-based survey assessing demographics, workplace stressors, perceived discrimination, life events, coping strategies, and physical and depressive symptoms. Study participants include 404 faculty of whom 254 are African Americans, 99 are Mexican Americans, and 51 are Puerto Ricans. Hierarchical regression analyses were employed to assess the associations between workplace stress, coping strategies, and symptoms. Results show that perceived discrimination, vocational strain, role overload, and life events directly affected physical symptoms, with self-care (p less then 0.001) moderating these effects. Vocational strain and life events had direct effects on depressive symptoms with self-care (p less then 0.05) and social support (p less then 0.001) moderating these effects. Findings inform health care providers and university leaders about work stress and health conditions that may explain early morbidity and premature departures of URM faculty, and proffer institutional interventions to retain these faculty.Despite strong evidence that individuals process stressor-strain relationships differently, little attention in work-family conflict research has been given to moderating effects of core self-evaluations (CSE). Integrating conservation of resources theory with work-family conflict and CSE research, we predicted that CSE has moderating effects between the relationships of work-to-family conflict (WFC) and voluntary turnover, job promotions, and physical health. We tested our predictions at two time points over a 14-month period with a sample of 731 working mothers in Japan. Results confirmed that CSE moderated the relationships between WFC and voluntary turnover, job promotions, and physical health, such that respondents with higher CSE had lower degrees of voluntary turnover, higher degrees of job promotions, and lower degrees of health problems. This study helps clarify the inconsistent effects of WFC on voluntary turnover in previous research, expands on the limited research examining WFC and job promotion, and provides consistent evidence that CSE act as a moderator between WFC and outcomes.Seabirds like gulls are common indicators in contaminant monitoring. The herring gull (Larus argentatus) is a generalist with a broad range of dietary sources, possibly introducing a weakness in its representativeness of aquatic contamination. To investigate the herring gull as an indicator of contamination in an urban-influenced fjord, the Norwegian Oslofjord, we compared concentrations of a range of lipophilic and protein-associated organohalogen contaminants (OHCs), Hg, and dietary markers in blood (n = 15), and eggs (n = 15) between the herring gull and the strict marine-feeding common eider (Somateria mollissima) in the breeding period of May 2017. Dietary markers showed that the herring gull was less representative of the marine food web than the common eider. We found higher concentrations of lipophilic OHCs (wet weight and lipid weight) and Hg (dry weight) in the blood of common eider (mean ± SE ∑PCB = 210 ± 126 ng/g ww, 60 600 ± 28 300 ng/g lw; mean Hg = 4.94 ± 0.438 ng/g dw) than of the herring gullnefit of a multispecies approach for a thorough picture of contaminant status in urban marine ecosystems. Integr Environ Assess Manag 2021;17422-433. © 2020 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

Zhu-Tokita-Takenouchi-Kim (ZTTK, OMIM# 617140) syndrome is a rare, autosomal dominant genetic disorder caused by heterozygous variants in the SON gene (OMIM#182465, GenBank#NC_000021.9). There are only 33 cases and 26 causative SON variants reported to date since the first report in 2015. Here, we report a new case of ZTTK syndrome and a de novo disease-causing SON variant.

We conducted whole-exome sequencing (WES) to obtain genetic data of the patient. The clinical and genetic data of the patient were analyzed.

The clinical features of our patient were strikingly similar to previously reported cases. Notably, our patient had unique presentations, including a bridged palmar crease in the left hand and growth hormone deficiency. Selleckchem EGFR inhibitor The c.5297del de novo variant in SON causes an amino change (p.Ser1766Leufs*7).

Our report expands the mutant spectrum of the SON gene and refines the genotype-phenotype map of ZTTK syndrome. Our findings also highlighted the importance of WES for early diagnosis of ZTTK syndrome, which may improve diagnostic procedures for affected individuals.

Our report expands the mutant spectrum of the SON gene and refines the genotype-phenotype map of ZTTK syndrome. Our findings also highlighted the importance of WES for early diagnosis of ZTTK syndrome, which may improve diagnostic procedures for affected individuals.Vortex flow fields are widely used to manipulate objects at the microscale in microfluidics. Previous approaches to produce the vortex flow field mainly focused on inertia flows. It remains a challenge to create vortexes in Stokes flow regime. Here we reported an evaporation induced spontaneous vortex flow system in Stokes flow regime by engineering Marangoni flow in a micro-structured microfluidic chip. The Marangoni flow is created by nonuniform evaporation of surfactant solution. Various vortexes are constructed by folding the air-water interface via microstructures. Patterns of vortexes are programmable by designing the geometry of the microstructures and are predictable using numerical simulations. Moreover, rotation of micro-objects and enrichment of micro-particles using vortex flow is demonstrated. This approach to create vortexes will provide a promising platform for various microfluidic applications such as biological analysis, chemical synthesis, and nanomaterial assembly.