Hullgoodwin3169

PURPOSE Ingestion of sildenafil citrate has performance-enhancing effects at high altitudes above 3800 m in able-bodied individuals. It is unknown whether it can improve the performance of athletes with spinal cord injury (SCI) at moderate altitudes ( less then 2200 m), relevant to Paralympic competitions. As most men with SCI suffer from erectile dysfunction of neurologic origin and use sildenafil on a regular basis, it seems important to study the impact of sildenafil on exercise capacity. The outcome of this study is also relevant to the antidoping community. METHODS Twenty-seven healthy male wheelchair athletes with a motor-complete SCI participated in this prospective double-blind, randomized, placebo-controlled study. The participants performed arm cranking exercise to exhaustion at sea level and moderate altitude (2200 m) after ingestion of 50 mg sildenafil citrate or a placebo. Peak power output, peak oxygen uptake, peak heart rate, rating of perceived exertion, oxygen saturation, and lactate concentrations at exhaustion were measured. RESULTS Friedman analysis showed that peak power output at sea level was significantly higher (P = .004) under placebo treatment (median [minimum; maximum] 120 W [35; 170]) compared with sildenafil (115 W [40; 165]). Blood oxygen saturation under sildenafil treatment at sea level (98% [81; 100]) was significantly higher (P = .006) compared with sildenafil treatment at moderate altitude (94% [85; 100]). All other parameters revealed no impact of sildenafil or altitude. CONCLUSIONS In this study, the ingestion of sildenafil citrate in athletes with SCI demonstrated no positive effects on peak arm-cranking-exercise capacity compared with placebo either at sea level or at moderate altitude.PURPOSE To evaluate the effect of drop jumps (DJs) on performance time and pacing in a field test (ie, 1000 m) commonly used to evaluate endurance runners and to evaluate running and jumping performance in male and female athletes separately. METHODS Twenty elite endurance runners (male, n = 10, 27.8 [7.0] y, 62.3 [5.2] kg; female, n = 10, 25.9 [5.3] y, 51.7 [4.1] kg) competing in middle- and long-distance events participated in this study. After determination of the box height associated with the best reactive strength index, athletes randomly performed a warm-up with or without the inclusion of 5 DJs with the highest reactive strength index prior to a 1000-m track test. Performance time and pacing (250-m splits) were determined. Countermovement-jump heights at different time points and blood lactate concentration after running tests were also recorded. RESULTS A "possible" faster 1000-m time (162.4 vs 165.3 s) with a "very likely" faster first split (38.8 vs 40.3 s) was observed in male athletes in the DJ condition. In contrast, female athletes showed a "possible" slower running time (186.8 vs 184.8 s) and a "likely" greater blood lactate concentration after the 1000-m test in the DJ condition. Male and female athletes presented greater countermovement-jump performances after warm-up and running tests in both conditions. CBR-470-1 cell line CONCLUSIONS The inclusion of 5 DJs with the height associated with the best reactive strength index induced a "possible" improvement in 1000-m performance time in elite male endurance runners. The current protocol should be avoided in female athletes.PURPOSE To validate a new perceptually regulated, self-paced maximal oxygen consumption field test (the Running Advisor Billat Training [RABIT] test) that can be used by recreational runners to define personalized training zones. DESIGN In a cross-sectional study, male and female recreational runners (N = 12; mean [SD] age = 43 [8] y) completed 3 maximal exercise tests (2 RABIT tests and a University of Montreal Track Test), with a 48-hour interval between tests. METHODS The University of Montreal Track Test was a continuous, incremental track test with a 0.5-km·h-1 increment every minute until exhaustion. The RABIT tests were conducted at intensities of 11, 14, and 17 on the rating of perceived exertion (RPE) scale for 10, 5, and 3 minutes, respectively, with a 1-minute rest between efforts. RESULTS The 2 RABIT tests and the University of Montreal Track Test gave similar mean (SD) maximal oxygen consumption values (53.9 [6.4], 56.4 [9.1], and 55.4 [7.6] mL·kg-1·min-1, respectively, P = .722). The cardiorespiratory and speed responses were reliable as a function of the running intensity (RPE 11, 14, and 17) and the relative time point for each RPE stage. Indeed, the oxygen consumption, heart rate, ventilation, and speed values did not differ significantly when the running time was expressed as a relative duration of 30%, 60%, or 90% (ie, at 3, 6, and 9 min of a 10-min effort at RPE 11; P = .997). CONCLUSIONS The results demonstrate that the RABIT test is a valid method for defining submaximal and maximal training zones in recreational runners.BACKGROUND The present study examined, among weight-stable overweight or obese adults, the effect of increasing doses of exercise energy expenditure (EEex) on changes in total daily energy expenditure (TDEE), total body energy stores, and body composition. METHODS Healthy, sedentary overweight/obese young adults were randomized to one of 3 groups for a period of 26 weeks moderate-exercise (EEex goal of 17.5 kcal/kg/wk), high-exercise (EEex goal of 35 kcal/kg/wk), or observation group. Individuals maintained body weight within 3% of baseline. Pre/postphysical activity between-group measurements included body composition, calculated energy intake, TDEE, energy stores, and resting metabolic rate. RESULTS Sixty weight-stable individuals completed the protocols. Exercise groups increased EEex in a stepwise manner compared with the observation group (P less then .001). There was no group effect on changes in TDEE, energy intake, fat-free mass, or resting metabolic rate. Fat mass and energy stores decreased among the females in the high-exercise group (P = .007). CONCLUSIONS The increase in EEex did not result in an equivalent increase in TDEE. There was a sex difference in the relationship among energy balance components. These results suggest a weight-independent compensatory response to exercise training with potentially a sex-specific adjustment in body composition.