Brockbisgaard2748

Overall, our results suggest that the accumulation of 8-oxodG at gene promoters occurs through DNA replication-dependent or -independent mechanisms, with a possible contribution to the formation of cancer-associated translocation events. © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.The objectives were to determine the expression frequency and sexual dimorphism of 15 dental morphological traits on the permanent dentitions of living Jordanians, and to compare the dental morphological pattern of this sample with those of 22 groups representing the various geographic regions of the world, for the purpose of assessing the population structure and genetic history of this group. Cone beam computed tomography images for the dentitions of 150 adult Jordanians (67 males, 83 females; age range = 18-58, mean ages 28.2, sd = 10.0 years) were studied in 2017. The traits were classified using the Arizona State University dental anthropology system, counted with the individual count method, and dichotomized according to the criteria of Scott & Turner for the purpose of group comparisons. Fisher's exact test for dichotomized scores was used to assess sexual dimorphism in these traits. Smith's Mean Measure of Divergence was used to measure all pairwise distance values among the groups. Statistically significant sexual dimorphism was found in two traits (i.e., UI1 shoveling and 4-cusped LM1), and apparent but statistically insignificant difference was found in three traits (i.e., UC canine mesial ridge, 3-rooted LM1, and 1-rooted LM2), all in favour of females. This study revealed that the dental pattern of Jordanians is distinct from the other reported Western Eurasian patterns and all other known dental patterns. This differentiated dental pattern suggests a genetic drift for this population from the Western Eurasian Ancestry.The height of an individual (stature) is one of the biological profiles that is estimated as part of human identification process from various components of the human skeleton. The anatomical method is often used for this purpose when a complete and intact skeleton is available for forensic analysis because it is accurate. Since complete skeletons are seldom present in most forensic cases, the mathematical method, which shows linear relationship between stature and bone measurements, becomes the method of choice. Population and sex-specific regression equations for stature estimation have been formulated using intact and fragmentary long bones amongst South African whites and blacks. Selleckchem PD-1/PD-L1 Inhibitor 3 Individual and combinations of measurements of other skeletal elements including bones of the feet have also been used in the formulation of regression equations. However, few studies have utilized measurements of the skull for stature reconstruction. Skeletal height, calculated from a suite of measurements, was regressed on six cranial measurements. Basibregmatic height and basion-nasion length presented with the highest correlation coefficient for an individual variable in males (0.50) and females (0.48), respectively. The range of correlation coefficient from multivariate analyses in males (0.58-0.63) is similar to that obtained in females (0.55-0.62). The standard error of estimates of the equations, a measure of the accuracy of the equations, for male sample (6.74-7.09) was slightly higher than that for females (5.47-5.89). Regression equations presented in this study should be used with caution in forensic cases when only the skull is available for human identification. Significance of main findings 1. Skull measurements show low to moderate correlation with stature. 2. Use of skull dimensions is advised only in the absence of intact long bones and other skeletal elements in South Africa.Adolescence is a significant event in woman's life when the process of menstruation occurs with several physical, mental and physiological developments. Menstrual experience of women is largely determined by environmental factors occurring during this period. In India, disparities in numerous factors result in different menstrual characteristics, menstruation-related symptoms and menstrual hygiene-related practices. However, the effect of residential status on the menstrual characteristics of adolescent girls is still unknown. In this context, the present study attempted to explore the variation in overall socio-economic condition and menstrual experience of tenant adolescent girls in comparison to freeholder adolescent girls. A well-structured questionnaire was used to collect information from 167 freeholder and 133 tenant adolescent schoolgirls on socio-economic and menstrual characteristics, menstruation-related symptoms and menstrual hygiene-related practices. Results showed that differences existed for these traits between freeholder and tenant adolescents. The key factors behind unsatisfied menstrual experience of tenant adolescent girls were lack of privacy, unsuitable sanitation facilities and use of cloth as preferred absorbent.BACKGROUND Notoginsenoside R1 (NR) is a major dynamic constituent of Panax notoginseng found to possess anti-inflammatory activity against various inflammatory diseases. However, its protective effects against renal ischemia-reperfusion (I/R) injury have not been elucidated. In male Wistar rats, we induced I/R under general anesthesia by occluding the renal artery for 60 min, followed by reperfusion and right nephrectomy. MATERIAL AND METHODS Rats were randomized to 4 groups a sham group, an I/R group, an NR-pretreated (50 mg/kg) before I/R induction group, and an NR control group. All animals were killed at 72 h after I/R induction. Blood and renal tissues were collected, and histological and basic renal function parameters were assessed. In addition, levels of various kidney markers and proinflammatory cytokines were measured using RT-PCR, ELISA, and immunohistochemistry analysis. RESULTS After I/R induction, the onset of renal dysfunction was shown by the elevated levels of serum urea, creatinine levels, and histological evaluation, showing a 2-fold increase in the renal failure markers kim-1 and NGAL compared to control rats. Rats pretreated with NR before I/R induction had significantly better renal functions, with attenuated levels of oxidative markers, restored levels of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), tumor growth factor-ß1 (TGF-ß1), INF-γ, and IL-6, and increased anti-inflammatory cytokine levels (IL-10) compared to I/R-induced rats. CONCLUSIONS NR suppressed I/R-induced inflammatory cytokines production by suppressing oxidative stress and kidney markers, suggesting that NR is a promising drug candidate for prevention, progression, and treatment of renal dysfunction.