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urg. Med. © 2020 Wiley Periodicals LLC.
Keloids are a common condition with variable rates of treatment satisfaction. Lasers have been used in an attempt to improve clinical appearance and associated symptoms. We report a significant reduction in pain for patients treated exclusively with a 1064 nm NdYAG laser. Lasers Surg. Med. SW033291 price © 2020 Wiley Periodicals LLC.Indoxacarb is a typical chiral insecticide widely used in agricultural pest control. In the present study, zebrafish was used as a model animal to explore the enantioselective bioaccumulation behavior of indoxacarb to nontarget species in aquatic environments. Zebrafish were exposed to 0.025 and 0.1 mg/L rac-indoxacarb solution for 12 d under the semistatic method, and the bioconcentration factor (BCF) and enantiomeric fraction of zebrafish were investigated. The results showed that the (-)-R-indoxacarb preferentially accumulated in zebrafish. The BCF values at 0.025 mg/L exposure levels were 1079.8 and 83.4 L/kg for (-)-R-indoxacarb and (+)-S-indoxacarb after 12 d, respectively. The BCF values at 0.1 mg/L exposure levels were 1752.1 and 137.0 L/kg for (-)-R-indoxacarb and (+)-S-indoxacarb after 10 d, respectively. The half-life values of (-)-R-indoxacarb and (+)-S-indoxacarb were 3.47 and 2.05 d for 0.025 mg/L concentration exposure and 4.95 and 2.66 d for 0.1 mg/L concentration exposure, respectively. The enantiomeric fraction values were in the range of 0.48 to 0.55 and 0.89 to 1.00 for water and zebrafish samples, respectively. Studies on the enantioselective bioaccumulation behavior of indoxacarb will provide data for assessing the environmental fate and potential toxic effects of indoxacarb on aquatic organisms. Environ Toxicol Chem 2021;401007-1016. © 2020 SETAC.Cyanobacteria are ubiquitous photosynthetic prokaryotes that produce structurally diverse bioactive metabolites. Although microcystins are extensively studied, other cyanopeptides produced by common bloom-forming species have received little attention. Cyanopeptolins are a large cyanopeptide group that contain a characteristic 3-amino-6-hydroxy-2-piperidone (Ahp) moiety. In the present study we used diagnostic fragmentation filtering (DFF), a semitargeted liquid chromatography-tandem mass spectrometry (MS/MS) product ion filtering approach, to investigate cyanopeptolin diversity from 5 Microcystis strains and 4 bloom samples collected from lakes in Ontario and Quebec, Canada. Data processing by DFF was used to search MS/MS data sets for pairs of diagnostic product ions corresponding to cyanopeptolin partial sequences. For example, diagnostic product ions at m/z 150.0912 and 215.1183 identified cyanopeptolins with the NMe-Tyr-Phe-Ahp partial sequence. Forty-eight different cyanopeptolins, including 35 new variants, were detected from studied strains and bloom samples. Different cyanopeptolin profiles were identified from each sample. We detected a new compound, cyanopeptolin 1143, from a bloom and elucidated its planar structure from subsequent targeted MS/MS experiments. Diagnostic fragmentation filtering is a rapid, easy-to-perform postacquisition metabolomics strategy for inferring structural features and prioritizing new compounds for further study and dereplication. More work on cyanopeptolin occurrence and toxicity is needed because their concentrations in freshwater lakes after blooms can be similar to those of microcystins. Environ Toxicol Chem 2021;401087-1097. © 2020 SETAC.Psychotherapy research shows that-in individual therapy as in family therapy-some therapists are more effective than others. This highlights the crucial role the therapist plays in a client's improvement. Furthermore, it seems that training may make a difference, as deliberate practice can improve the therapist's effectiveness. In the context of the current renewed awareness of the importance of the person of the therapist in the psychotherapy field, this paper's focus is specifically on the therapist in family therapy practice. There is a long tradition of reflecting on the person of the therapist in the family therapy field, often inspired by the metaphor of the wounded healer. In contrast, focusing on the person op the therapist in the present moment of the therapy session is fairly new. In this paper, we use of the dual process models from cognitive psychology as a frame to reflect on the person of the therapist. We review these dual process models and propose that the intuitive responsivity of the therapist relies on the fast, implicit cognitive system (system 1) and the therapist's self-reflection on the slow, deliberate system (system 2). The therapist's actions in therapy practice then emerge moment-by-moment as an echo of the way these two cognitive systems balance each other. It is optimal if the therapist, attuned to the family's rhythm, can flexibly oscillate between the two systems. In the concluding comments of this paper, reflective questions are posed about what this perspective may mean for family therapy practice, training, and supervision.
This study intended to contribute to the improvement of nursing care for both children and their parents and aimed to identify the best and worst experiences of school-aged children during hospitalisation.
Child hospitalisation has traditionally been studied from the parent's perspective, but studies in which the child is the subject are scarce and mainly focus on to the hospitalisation experiences.
A cross-sectional, observational and descriptive exploratory design was used, and STROBE reporting guidelines were followed.
A paper survey was applied by the primary researcher within a 3months period to 252 children. It presented two open-ended statements 'In my opinion the best thing about the hospital is …' and 'In my opinion the worst thing about the hospital is…'. The study was submitted and approved by the national data protection commission and also by the ethics committees of each of the six institutions where the study was undertaken. Informed consent was also obtained from children and parents.
Answers were analysed through content analysis. Five categories were identified for each of the open-ended statements. Children identified 'people', 'physical environment', 'activities', 'outcomes' and 'food' as best experiences. The worst experiences included 'feelings', 'activities', 'food', 'environment' and 'outcomes'.
The results allowed the identification of the children's most valued aspects of hospitalisation.
The results should be considered by healthcare professionals in order to make the hospitalisation experience more positive from the perspective of the school-aged children.
The results should be considered by healthcare professionals in order to make the hospitalisation experience more positive from the perspective of the school-aged children.
