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The maximum adsorption capacity (qmax) was calculated to be 15.16 mg g-1 (at 25 °C), which is comparable or superior to other adsorbent materials used in DZP removal. Reuse experiments showed that GA-g-PAAc keeps appreciable adsorption ability even after five reuse cycles. The results reported here suggest this superabsorbent hydrogel could be a promising adsorbent material to treat water contaminated by anxiolytic drugs, like DZP.Given that improving urban ecological environment requires a clear recognition of the urban ecological elements, investigating the ecosystem service capabilities of urban green-blue infrastructures (UGBIs) becomes ever important. This study aims to reveal and compare the synergistic ecosystem service ability of UGBIs with different characteristics and the relationship with human demand in Wuhan city. It was found that the climate regulation service and water regulation service value of lake-type parks both reached the highest over the other UGBIs. Nature-type parks revealed the most capable cultural service, and green-type parks demonstrated the greatest exercise cultural service value. The analysis showed that the ecosystem services delivered by the UGBIs were influenced by the park area, the total value of the normalized difference vegetation index and normalized water body index, and the distance from the city centre. Furthermore, a significant spatial phenomenon was found that the ecological capacity of lake-type parks in the city centre was higher than that of the other UGBIs at the same location. Regarding the relationship with the human activity intensity, the high-demand and high-supply regions were mainly concentrated in highly developed areas in terms of regulating services. Nevertheless, a severe environmental inequality occurred in small urban centres, which requires urgent attention from the government. This work answered the question of where and how to optimize the green-blue infrastructures in Wuhan, and it contributes to the construction of the existing blue-green space.A novel series of multitargeted molecules were designed and synthesized by combining the pharmacological role of cholinesterase inhibitor and antioxidant of steroid as potential ligands for the treatment of Vascular Dementia (VD). The oxygen-glucose deprivation (OGD) model was used to evaluate these molecules, among which the most potent compound ML5 showed the highest activity. Firstly, ML5 showed appropriate inhibition of cholinesterases (ChEs) at orally 15 mg/kg in vivo. The further test revealed that ML5 promoted the nuclear translocation of Nrf2. Furthermore, ML5 has significant neuroprotective effect in vivo model of bilateral common carotid artery occlusion (BCCAO), significantly increasing the expression of Nrf2 protein in the cerebral cortex. In the molecular docking research, we predicted the ML5 combined with hAChE and Keap1. Finally, compound ML5 displayed normal oral absorption and it was nontoxic at 500 mg/kg, po, dose. We can draw the conclusion that ML5 could be considered as a new potential compound for VD treatment.The prevalence of pressure ulcers in patients with spinal cord injuries has been estimated to be between 30% and 47%. selleck chemicals Individuals with spinal cord injuries sit for a majority of the time, increasing the risk of developing pressure ulcers in the buttocks and thighs due to large internal stresses. Human body models have been developed to study the formation of pressure ulcers, yet a persistent limitation in these models has been the material properties used to represent the soft tissues in the buttocks and thighs. Specifically, soft tissue material property data have not included wheelchair users, such as those with spinal cord injuries. The goals of this research were 1) to determine the in-vivo material properties of soft tissue in the thighs and buttocks of individuals with spinal cord injuries and 2) compare these to properties obtained from able-bodied people. Results indicated that the proximal and middle thigh regions of those who had a spinal cord injury were softer than the same regions as able-bodied individuals, while the distal thigh regions were stiffer. These findings are vital because they indicate that models developed using properties from able-bodied individuals will not produce internal stress or strain magnitudes that represent individuals who have a spinal cord injury. This information suggests that models should obtain material property data sets from their desired population. Human body models must represent the population being studied if they are to inform clinical assessments and make accurate patient predictions.A method for separating linear and nonlinear components in high-resolution transmission electron microscope imaging has been reported by Chang (Microscopy, 2016. 65 p. 465-472), and a deep understanding has been obtained as to the variation of the linear and nonlinear components with the sample thickness. However, the images used for the separation in the abovementioned study are simulated under ideal conditions, without considering errors in experiments. Therefore, in this study, to verify the practicability of the abovementioned method, experimental details will be systematically considered, such as image mismatch, inaccuracy of the spherical aberration, focus, and residual highfold aberrations A2, B2 etc., based on the AlN simulated image, to determine the margin of error of the abovementioned parameters and provide theoretical guidance for experiments.Autobiographical memories serve psychosocial functions in daily life and the use of memories is related to their valence. In the present study, we examined whether functions are also related to the intensity of positive and negative memories. Our sample included 110 participants (57-89 years of age). Memories were prompted with 30 emotionally neutral cue words. Participants rated the emotional quality of each memory and indicated how frequently they had recalled it for self-continuity, directing behavior, social-bonding, and mood-enhancement. We used multilevel modeling to test whether individual differences in the use of memories can explain why individuals recall different numbers of positive and negative memories as well as memories high or low in intensity. Each function revealed its specific pattern regarding valence and intensity but also regarding within-person and between-person effects. Mood-enhancement showed the strongest relations, which points to the importance of considering emotion regulation as a function of autobiographical memory.