Mckinnonmcclain2950

h effectively lowered the risk of DDIs. Meanwhile, HIPPEs provided outstanding UV, thermal and oxidation protection for these two environmentally sensitive anti-cancer drugs. In addition, HIPPEs displayed a good pH-responsive release in a tumor environment. In vitro experiments show that the killing efficiency of two drugs co-loaded HIPPEs against the leukemia cell is two times higher than that of single drug loaded systems. This strategy can be extended to the synergistic therapy of two or more drugs with different physicochemical properties.The nonsolvent induced phase separation (NIPS) method for ultrafiltration (UF) membrane fabrication relies on the extensive use of traditional solvents, thus ranking first in terms of ecological impacts among all the membrane fabrication steps. Methyl-5-(dimethylamino)-2-methyl-5-oxopentanoate (PolarClean), as a green solvent, was utilized in this study to fabricate poly(vinyl chloride) (PVC) UF membranes. Subsequently, in post-treatment process, zwitterionic polymer, [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), was grafted onto the membrane surface to enhance its anti-fouling properties using a greener surface-initiated activator regenerated by electron transfer-atom transfer radical polymerization (ARGET-ATRP) reaction. This novel method used low toxicity chemicals, avoiding the environmental hazards of traditional ATRP, and greatly improving the reaction efficiency. We systematically studied the grafting time effect on the resulted membranes using sodium alginate as the foulant, and found that short grafting time (30 min) achieved excellent membrane performance pure water permeability of 2872 L m-2 h-1 bar-1, flux recovery ratio of 86.4% after 7-hour fouling test, and foulant rejection of 96.0%. This work discusses for the first time the greener procedures with lower environmental impacts in both fabrication and modification processes of PVC UF membranes.It is a considerable challenge to develop environmental friendly, low-cost methodology for green preparation of carbon dots (CDs). FICZ cell line Herein, CDs with different surface states are prepared using o-phenylenediamine (o-PD) and hydroquinone (HQ) as precursors via oxidation/polymerization and Schiff base reaction at room temperature without additional oxidizing agents. Two CDs products (YCDs and GCDs) are obtained after separation with silica gel column chromatography based on their polarity differences. The different surface states endow these two CDs with different properties. The rich NO2 and OH groups on the surface of YCDs contribute to a narrow band gap, resulting in the red-shifted photoluminescence (PL) emission of this CDs product, making it a sensitive probe for the detection of toxic pollutant p-nitrophenol (p-NP) attributed to the inner filter effect, along with a detection limit of 0.08 μmol/L. GCDs are characterized with abundant surficial NH2 groups, and can be used as a potential probe to detect H2O content in D2O, giving a detection limit of 0.17 vol%.The specific roles of Ni and Fe in nickel-iron (oxy)hydroxide catalyst (NiFeOx(OH)y) are extensively discussed during oxygen evolution reaction (OER). However, there still remains controversy about whether Ni or Fe species as the dominate active site. In this work, we reported the NiFeOx(OH)y catalysts with varied atomic ratio of nickel and iron for OER to explore the dominate active site during OER processes. From the electrochemical performances, the similar Tafel slopes of catalysts with Fe species can achieve at a level of 40 mV dec-1, outperforming the Tafel slopes of catalysts without Fe species. Thus, it can be concluded that the present Fe site can serve as the dominant active site in NiFeOx(OH)y for OER. Meanwhile, the Ni species is proved as the OH- adsorption site, which is beneficial to the Fe site to deliver a better OER performance. As a result, the catalyst with an optimal Ni/Fe interface (atomic ratio of 1 1.18) displays outstanding OER performances. It only requires a low overpotential of 250 mV to deliver current density of 10 mA cm-2 and exhibits a small Tafel slope of 39 mV dec-1. This catalyst also shows remarkable stability with negligible potential decay after 50 h at a current density of 50 mA cm-2. This work offers a new sight into the specific roles of Ni and Fe in NiFeOx(OH)y for OER.The aim of this study was to examine the impact of an autonomy-supportive yoga intervention on the self-determination of adults with intellectual and developmental disabilities. Research supports the use of autonomy-supportive interventions to increase positive health outcomes with this population. The present study utilized a qualitative approach with eight subjects participating in semi-structured qualitative interviews. Content analysis identified support for three themes related to the impact of yoga autonomy, relatedness, competence. The results suggested that the yoga intervention may support self-determination for adults with IDD, as the participants' responses demonstrated increased feelings of autonomy, competence, and relatedness. The results also indicated that an autonomy-supportive yoga intervention can be achieved with adults with intellectual and developmental disabilities by targeting the key constructs of autonomy, relatedness, and competence.Pressure injury (PI) is a worldwide health problem that has attracted widespread attention from scientific and clinical research communities. PI incidence correlates with the increase of the aging population. In this situation, it is crucial to select effective and affordable drugs for patients and healthcare systems. Herein, we report a case of a 94-year-old female with a stage 2 PI wound, which was treated topically using a novel combination of mixed powders metronidazole and nano pearl powders. Metronidazole is the preferred option to treat infected wounds due to its excellent antibacterial ability. However, some drawbacks have limited the use of metronidazole in PI wound management, such as its poor capacity to accelerate wound closure. Pearl powder has a strong capacity to promote wound healing and closure but has not been effective at resisting wound infection. To take advantage of powdered drugs' wound treatment properties and accelerate PI wound healing, we prepared powdered mixtures for wound application.