Ralstonrosendahl9088

Our innovative studies indicate the important links between WT TP53 and DDR1 which can modulate Raf/MEK/ERK and PI3K/Akt signaling as well as chemosensitivity and aging. Methods We investigated the roles of wild type (WT) and mutant TP53 on drug sensitivity of prostate cancer cells and the induction of Raf/MEK/ERK, PI3K/Akt and DDR1 expression and chemosensitivity.Background Regular physical activity and doing well in school are important for growing adolescents. In this study, the associations between physical activity and perceived school performance (PSP) are examined together. Methods Young adolescents from 42 countries (n = 193,949) in Europe and Canada were examined for associations between self-reported moderate to vigorous physical activity (MVPA) and PSP. Multinominal analyses were conducted with 0 to 2 days of MVPA and below average PSP as reference categories. Adjusted odds ratios and 95% confidence intervals were reported for pooled data and individual countries after controlling for family affluence scale. Results Girls had better PSP than boys, yet more boys participated in daily MVPA than girls. The associations between PSP and MVPA were inverted U shaped. The strongest association for very good PSP was among young adolescents who reported 5 to 6 days MVPA (odds ratios = 2.3; 95% confidence interval, 2.1-2.4) after controlling for family affluence scale. Conclusions Young adolescents with average or better PSP took part in at least 3 days of MVPA in a week, suggesting that participating in some MVPA was positively associated with PSP. More days of MVPA in a week, especially for young adolescents with below average PSP, would be beneficial for health and school performance.Slip outcomes are categorized as either a backward loss of balance (LOB) or a no loss of balance (no-LOB) in which an individual does not take a backward step to regain their stability. LOB includes falls and nonfalls, while no-LOB includes skate overs and walkovers. Researchers are uncertain about which factors determine slip outcomes and at which critical instants they do so. The purpose of the study was to investigate factors affecting slip outcomes in proactive and early reactive phases by analyzing 136 slip trials from 68 participants (age 72.2 [5.3] y, female 22). Segment angles and average joint moments in the sagittal plane of the slipping limb were compared for different slip outcomes. DW71177 The results showed that knee flexor, hip extensor, and plantar flexor moments were significantly larger for no-LOB than for LOB in the midproactive phase, leading to smaller shank-ground and foot-ground angles at the slip onset, based on forward dynamics. In the early reactive phase, the hip extensor and plantar flexor moments were larger for no-LOB than for LOB, and all segment angles were smaller for no-LOB. Our findings indicate that the shank angle and knee moment were the major determinants of slip outcomes in both proactive and reactive phases.Background With the pervasiveness of social media, online health communities (OHC) are an important tool for facilitating information sharing and support among people with chronic health conditions. Importantly, OHCs offer insight into conversations about the lived experiences of people with particular health conditions. What is less known is what aspects of OHCs are important to maintain safe and productive conversations that support health. Objective This research aims to assess the provision of social support and the role of active moderation in OHCs developed in accordance with and managed by an adaptive engagement model. This study aims to identify key elements of the model that are central to the development, maintenance, and adaptation of OHCs for people with chronic health conditions. Methods This research uses Combined Content Analysis, a mixed-methods approach, to analyze sampled Facebook post comments from 6 OHCs to understand how key aspects of the adaptive engagement model facilitate different ty of others were most frequent (46%), followed by the expression of empathy and understanding (32%). Even among posts with more factual content, like insurance coverage issues, user comments still had frequent expressions of support for others (37%). Conclusions The analysis of this OHC Adaptive Engagement model-in-action shows that the foundational elements--social support, engagement, and moderation-can effectively be used to provide a rich and dynamic community experience for individuals with chronic health conditions. Social support is demonstrated in a variety of ways including through sharing information or validating information shared by others, expressions of empathy, and sharing encouraging statements with others.Background Airway stenting (AS) is performed for the treatment of benign or malignant central airway stenosis. In France, more than 30 centers practice AS. The aim of this survey was to evaluate the current practice around airway stenting among French bronchoscopy practitioners. Method We performed an online survey sent to the GELF group (Groupe d'Endoscopie de Langue Française) mailing list. The first part comprised 10 questions about the different attitudes before AS and the second part included 10 questions about the management after AS. Results Thirty-six participants answered to the first part of the questionnaire and thirty-three to the second. There were some similarities, for example the absence of prophylactic antibiotic treatment before procedure (86%), use of saline nebulization, and removing or replacing the airway stent in case of persistent chest congestion or infection (73%). We also noted an important heterogeneity of the practices with several differences concerning systematic endoscopic control, bacteriological sampling before procedure (44%) and systematically AS replacement. Conclusion This survey shows that AS management in France varies between practitioners. Respondents agreed on a few points, but disagreed on several important aspects of the management. These results emphasize the need of expert recommendations to improve AS management.Background How health-care professionals inform cystic fibrosis patients and their relatives about transplantation is not well known. Such information may not be provided in a timely or satisfactory manner. We conducted a survey about patient information practices among professionals from all French cystic fibrosis centers and transplant centers, to determine how they might be improved. Methods This was a national, retrospective, multicenter, descriptive assessment of practices involving health-care professionals, transplant recipients and their relatives, and peer patients who are themselves transplant recipients. Questionnaires were developed by the French working group on cystic fibrosis patient education (GETHEM Groupe éducation thérapeutique et mucoviscidose). At the end of the questionnaires, respondents were invited to suggest ways to improve the current process. Results In all, 216 professionals, 55 patients, 30 relatives of these patients, and 17 peer patients responded to the questionnaires, which addressed topics in chronological order, from neonatal screening or later diagnosis of the illness to the time of the transplant, if one was performed.