Colemantemple5010
Wearable step-counter devices have become inexpensive tools that enable patients, researchers, and clinicians to objectively monitor physical activity. It is unknown how the use of gait aids, such as canes, crutches, and walkers, affects the accuracy of these devices. Such gait aids are commonly used by patients with chronic physical impairment and after joint-replacement surgery. The aim of this study was to determine the effect of gait aids on the accuracy of wearable step counters.
Nine healthy participants wore a Fitbit step counter on their wrist and hip and performed eight walking tests with canes, crutches, and walkers. Bland-Altman analyses were performed for all eight walking tests in order to compare agreement between measurement techniques.
Mean overall agreement for subjects walking without gait aids in the hip group was excellent, showing a bias of -2.9, with limits of agreement (LOAs) between -8.72 and 2.95. For use of canes or crutches, the Bland-Altman plots had a range of bias values between the hip and wrist counters from -7.22 to 33.56, with LOAs from -98.55 to 124.2. The wrist counter during the four-wheeled walking test showed very little agreement with the actual step count, with a bias value of 91.33 and LOAs of 64.1-118.6, illustrating exceptionally unreliable step counts.
This study suggests that these widely commercially available step counters have poor reliability with gait aids, especially walkers, which should be taken into account in research and clinical settings.
This study suggests that these widely commercially available step counters have poor reliability with gait aids, especially walkers, which should be taken into account in research and clinical settings.Treatment-resistance is a frequent condition for obsessive-compulsive disorder (OCD). Over the past decades, a lot of effort has been made to address this issue, and several augmentation strategies of serotonergic drugs have been investigated. Antidopaminergic drugs are considered the first choice as augmentation strategy for treatment-resistant OCD patients, but they seem to work only for a subset of patients, and none of them have been officially approved for OCD. Recently, the role of glutamate and inflammation in OCD pathophysiology clearly emerged, and this has led to several investigations on glutamatergic and anti-inflammatory agents. Results seem promising but still inconclusive. Probiotic interventions (considered to modulate the immune systems and the brain activity) are gaining attention in several psychiatric fields but are still at their early stages in the OCD field. Research on new treatment approaches for OCD is moving forward, and more than one hundred interventional trials are ongoing around the world. While the vast majority of these trials involve neuromodulation and psychotherapeutic approaches, only a small proportion (around 20%) involve the investigation of new pharmacological approaches (tolcapone, nabilone, psilocybin, troriluzole, nitrous oxide, rituximab, naproxen, and immunoglobulins). Here, we provide a comprehensive review of investigational and experimental drugs to treat OCD.
A current challenge in malaria control and elimination is the progressive resistance to most antimalarial drugs which necessitates the discovery of new options. Hence, the current study was initiated to investigate the antimalarial activity of the stem bark of
in mice.
The test material was extracted using 80% methanol in a cold maceration technique and further fractionated in solvents of varied polarity. Acute oral toxicity was assessed following the OECD guideline no. 425 protocol. Then, the antimalarial activities of the crude extract and the fractions were evaluated in a 4-day suppression test. Rane's test was also used to evaluate the curative potential of the n-butanol fraction that showed the highest effect during the 4-day suppressive test. Parameters such as parasitemia suppression, mean survival time, packed cell volume, rectal temperature, and body weight were determined to establish the activity.
The acute oral toxicity test indicated that the plant did not cause any signs of behavioral c its traditional use for the treatment of malaria and laying the foundation for further investigations.
This study established that Fagaropsis angolensis had shown potential antimalarial activity as evidenced by the significant effects in the different parameters, upholding its traditional use for the treatment of malaria and laying the foundation for further investigations.
Maternal undernutrition rates in Ethiopia are among the highest in the world. In addition, a huge inequity exists within the country, with pregnant women in rural communities being at increased risk. This study assessed the prevalence of undernutrition and its associated factors among pregnant women in a rural community in southern Ethiopia.
A community-based cross-sectional study was conducted among 376 randomly selected pregnant women. Data were collected through face-to-face interview followed by mid-upper arm circumference measurement. Household food insecurity and minimum dietary diversity for women were assessed. Data were entered into EpiData 3.1 and exported to SPSS 20 for analysis. Logistic regression models were fitted to check associations between independent variables and undernutrition. Statistical significance was set at
<0.05.
The prevalence of undernutrition was 41.2% (95% CI 36.3%-46.3%). Unintended pregnancy (AOR 2.06, 95% CI 1.27-3.36) and not participating in Wome's Health Develuraging teenage and unintended pregnancy, reducing household food insecurity, and promoting antenatal care visits and encouraging consumption of diversified diets by women. Strengthening the existing network of the Women's Health Development Army seems to be very important.
The current emerging respiratory disease known as the novel Coronavirus 2019 (COVID-19) is now an international concern and a pandemic with non-availability of treatment. Due to altered physiology, weakened mechanical and immunological features pregnant mothers constitute a particularly suspectable segment of population in any infection pandemic. The goal of this study was to assess level of knowledge and attitude towards COVID-19 and determinants among pregnant mothers attending antenatal care (ANC) in Debre Tabor General Hospital Northwest Ethiopia.
An institutional-based cross-sectional study was performed from June 05 to 26, 2020. Selleckchem CP21 A total of 403 pregnant mothers participated and were selected by systematic random sampling. Data were collected via face-to-face interviewer-administered questionnaire. Data were entered using Epi-Data version 4.2 and analyzed by SPSS version 23. Bivariable and multivariable logistic regression analysis was performed and p-value <0.05 at 95% CI was considered as statistically significant.
