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To this end, the defective APP-mRNA isoform responsible for the disease in cells and tissues appears as an ideal target for epigenetic therapeutic intervention and antisense drugs are potential treatment. © 2019 the Author(s), licensee AIMS Press.The combination of Artificial Neural Networks and Fuzzy Logic Systems enables the representation of real-world problems via the creation of intelligent and adaptive systems. By adapting the interconnections between layers, Artificial Neural networks are able to learn. A computing framework based on the concept of fuzzy set and rules as well as fuzzy reasoning is offered by fuzzy logic inference systems. The fusion of the aforementioned adaptive structures is called a "Neuro-Fuzzy" system. In this paper, the main elements of said structures are examined. Researchers have noticed that this fusion could be applied for pattern recognition in medical applications. © 2019 the Author(s), licensee AIMS Press.Many theories of episodic memory posit that the subjective experience of recollection may be driven by the activation of stimulus-specific cortical regions during memory retrieval. This study examined cortical activation during associative memory retrieval to identify brain regions that support confidence judgments of source memory in stimulus-specific ways. Adjectives were encoded with either a picture of a face or a scene. During a source memory test, the word was presented alone and the participant was asked if the word had been previously paired with a face or a scene. We identified brain regions that were selectively active when viewing pictures of scenes or faces with a separate localizer scan. We then identified brain regions that were differentially activated to words during the source memory test that had been previously paired with faces or scenes, masked by the localizer activations, and examined how those regions were modulated by the strength of the source memory. Bilateral amygdala activation tracked source memory confidence for faces, while parahippocampal cortex tracked source memory confidence for scenes. The magnitude of the activation of these domain-specific perceptual-processing brain regions during memory retrieval may contribute to the subjective strength of episodic recollection. © 2019 the Author(s), licensee AIMS Press.It is well known that various types of information can be learned and memorized via repetitive training. In brain information science, it is very important to determine how neuronal networks comprising neurons with fluctuating characteristics reliably learn and memorize information. The aim of this study is to investigate the learning process in cultured neuronal networks and to address the question described above. Previously, we reported that the spikes resulting from stimulation at a specific neuron propagate as a cluster of excitation waves called spike wave propagation in cultured neuronal networks. We also reported that these waves have an individual spatiotemporal pattern that varies according to the type of neuron that is stimulated. Therefore, different spike wave propagations can be identified via pattern analysis of spike trains at particular neurons. Here, we assessed repetitive stimulation using intervals of 0.5 and 1.5 ms. Subsequently, we analyzed the relationship between the repetition of the stimulation and the identification of the different spike wave propagations. We showed that the various spike wave propagations were identified more precisely after stimulation was repeated several times using an interval of 1.5 ms. These results suggest the existence of a learning process in neuronal networks that occurs via repetitive training using a suitable interval. © 2019 the Author(s), licensee AIMS Press.At the cellular level, Alzheimer's disease (AD) is characterized by the presence of intracellular plaques containing amyloid beta (Aβ) protein and neurofibrillary tangles consisting of phospho-tau (p-tau). These biomarkers are considered to contribute, at least in part, to the neurodegenerative events of the disease. But the accumulation of plaques and tangles is widely considered to be a later event with other factors likely being the cause of the disease. Calcium dysregulation-the unregulated accumulation of calcium ions-in neurons is an early event that underlies neurodegeneration. In 2002, O'Day and Myre extended this "Calcium Hypothesis" to include calmodulin (CaM) the primary target of calcium, suggesting the "Calmodulin Hypothesis" as an updated alternative. Here we overview the central role of CaM in the formation of the classic hallmarks of AD plaques and tangles. Then some insight into CaM's binding to various risk factor proteins is given followed by a short summary of specific receptors and channels linked to the disease that are CaM binding proteins. Overall, this review emphasizes the diversity of Alzheimer's-linked CaM-binding proteins validating the hypothesis that CaM operates critically at all stages of the disease and stands out as a potential primary target for future research. © 2019 the Author(s), licensee AIMS Press.In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options. © 2019 the Author(s), licensee AIMS Press.Research in neuroscience is being very fruitful in providing evidence about the influence of social experience in the architecture and functioning of the brain. In so doing, neuroscience is posing new and fascinating research questions to examine in depth the social processes that produce those neural changes. Olaparib solubility dmso To undertake the task of tackling such research questions, evidence from the social sciences are necessary to better understand how different types of social experiences produce different types of synaptic changes and even modify subcortical brain structures differently. It will be the dialogue between neuroscience, other natural sciences and the social sciences which will advance the scientific understanding of plastic changes in the brain which result from complex social experiences that have been traditionally studied by the social sciences. Socioneuroscience constitutes the arena for such interdisciplinary dialogue and research that can both advance the scientific understanding of the human brain and provide evidence-based solutions to most urgent social problems.