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Tumor lysis syndrome is uncommon in solid tumors but with the use of immunotherapy (checkpoint inhibitors) their incidence is increasing. Physicians need to take adequate precautions while treating patients with immunotherapy. The findings of our case report will help improve our current understanding of tumor lysis syndrome specially in solid tumors and will help in developing multidisciplinary treatment and prophylaxis strategies for this uncommon, but potentially fatal complication. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Intralesional triamcinolone acetonide is an effective treatment for acanthoma fissuratum, and recognition of this condition can negate the need for unnecessary surgical intervention. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Adults with Down syndrome are more prone to develop intellectual, physical, and psychological disorders than their pediatric counterparts. It is pertinent to prevent the occurrence of severe complications in these patients. This case demonstrates the importance of support, regular follow-up, and wound management in self-care of adults with Down syndrome. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Aconitine intoxication by ingestion of Aconitum roots can lead to ventricular tachycardia and cardiac arrest and provides an example of the potential effect of self-medication. Educational campaigns should be implemented to contain acute intoxications caused by herbal-derived products. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Leptospirosis often takes clinicians by surprise when presenting in urban locations with unusual manifestations. This delays diagnosis and treatment which increases mortality rate. Our case illustrates the importance of taking into account the socioeconomic backgrounds, environmental exposures, and clinical presentations of patients to create a good differential diagnosis. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Prenatal DA closure due to early maternal intake of high-dose paracetamol and selective serotonin reuptake inhibitors. MC twin pregnancy uncomplicated by TTTS with discordant prenatal DA closure. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.This report describes a patient who presented with a large thyroid nodule and compressive symptoms. Immunohistochemical staining showed diffuse marked reactivity for vimentin and focal reactivity for CD68 and Ki-67 that is compatible with primary undifferentiated pleomorphic sarcoma of the thyroid. This report emphasizes and discusses extremely rare thyroid cancer type. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Gonadotropinoma in Klinefelter syndrome (KS) is uncommon and may be a result of protracted stimulation of gonadotrophs from lack of androgen feedback. Associations of white matter changes and increased venous thromboembolic risk have been reported and need to be considered in patients with KS. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.The following are the first detailed cases of Interdigital Pedal Erythrasma successfully treated with a one-time dose of oral clarithromycin 1 g. This is ideal for patients who failed topical therapy or have mechanical or psychosocial restrictions. Treatment provides better compliance, less gastric side effects, and lower treatment costs than oral alternatives. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Cutaneous metastases are rare and represent a sign of poor prognosis. They are a sign of widespread disease. Breast cancer is the most common neoplasm leading to their appearance. Palliative care is the treatment of choice. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.A two-stage multicomponent parenchymal sparing surgical strategy (anatomical extended on left hepatic vein 2-nd segment liver resection and R1vascular approach) allows the successful resection of synchronous multiple bilobar CRC metastases. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Our case is only the 2nd such reported case of atherothrombosis from ESAs and highlights the increased risk of cardiovascular events in patients receiving erythropoietin-stimulating agents specially patients with underlying MDS where targeting a lower hemoglobin goal and optimizing other cardiovascular risk factors might be beneficial in preventing future cardiovascular mortality. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Intravenous lipid emulsion (ILE) was administered to a cat with no adverse effects. This case report postulates that ILE can be used for the treatment of carprofen toxicity in cats and supports the lipid sink theory as the main mechanism of action. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.If familial hereditary tumor is suspected, diagnosis and treatment should always be performed considering the presence of familial hereditary tumors irrespective of whether genetic testing is performed. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Adenocarcinomas of intestinal type arising in mature cystic teratoma of ovary (MCT) are extremely rare and remain a diagnostic dilemma because of its similarities with MCT. Serum tumor markers CEA and SCC and also MRI may help in the preoperative diagnosis. Pathologist experience helps in intraoperative diagnosis. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.Calcium pyrophosphate dehydrate deposition (CPDD) disease very rarely affects the temporomandibular joint (TMJ). It may resemble synovial chondromatosis, chondrosarcoma, chondroblastoma, or a parotid tumor. read more Clinical examination, CT, and MRI are important in making the correct diagnosis. Surgical removal of CPDD is necessary with or without excision of the TMJ. © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.