Wallsmoran9439

1007/s43477-022-00042-7.

The online version contains supplementary material available at 10.1007/s43477-022-00042-7.In the acute phase of SARS-CoV-2 infection, varying degrees of clinical manifestations have been noticed in patients. Some patients who recovered from the infection developed long-term effects which have become of interest to the scientific and medical communities, as it relates to pathogenesis and the multidisciplinary approach to treatment. Long COVID (long-term or long-haul) is the collective term used to define recovered individuals of SARS-CoV-2 infection who have presented with persistent COVID symptoms, as well as the emergence of disorders and complications. Following the review of literature from major scientific databases, this paper investigated long COVID and the resulting post-sequela effects on survivors, regardless of initial disease severity. The clinical manifestations and multisystem complications of the disease specifically, cardiovascular, neurologic and psychologic, hematologic, pulmonary, dermatologic, and other ailments were discussed. Patients with chronic COVID-19 were found to experience heart thrombosis leading to myocardial infarction, inflammation, lung fibrosis, stroke, venous thromboembolism, arterial thromboembolism, "brain fog", general mood dysfunctions, dermatological issues, and fatigue. As the disease continues to progress and spread, and with the emergence of new variants the management of these persisting symptoms will pose a challenge for healthcare providers and medical systems in the next period of the pandemic. However, more information is needed about long COVID, particularly concerning certain patient populations, variability in follow-up times, the prevalence of comorbidities, and the evolution of the spread of infection. Thus, continued research needs to be conducted concerning the disease pathology to develop preventative measures and management strategies to treat long COVID.

COVID-19 forced the shutdown of colleges and socialization around the world including India and prolonged lockdown could have a significant impact on sleep, mood, emotion and anxiety in students. Here, we designed a survey to assess the effect of lockdown on sleep-wake, self-esteem, depression and anxiety via the survey on 321 Indian college-going students.

We assessed the effect of lockdown on sleep-wake (wake up, get up, bed and sleep timing, total time in bed and sleep duration) and self-esteem and depression on students via various questions.

We found that students delayed sleep timing by 1h in lockdown than pre-lockdown days. Specifically, urban male populations were late sleeper than any other group. However, total sleep duration did not differ between groups. In self-esteem questions, most students agreed that they were of no good, felt nervous, displeased, and frustrated about performance in lockdown. Depression and anxiety questionnaire gave more significant results related to mood and mental health. More than 50% of students agreed that they faced a lack of concentration, had been feeling irritated and angry, felt fatigued and tired, and everything had been a failure during lockdown days.

Overall, the survey suggests that lack of social life and prolonged lockdown affect the sleep-wake cycle, self-esteem, anxiety and depression of Indian students.

The online version contains supplementary material available at 10.1007/s41782-022-00200-9.

The online version contains supplementary material available at 10.1007/s41782-022-00200-9.Conversational agents are used to communicating with humans in a friendly manner. To achieve the highest level of performance, agents need to respond assertively and fastly. Transformer architectures are shown to produce excellent performances on recent tasks; however, for tasks involving conversational agents, they may have a lower speed performance. The main goal of this study is to evaluate and propose a HoPE (Healthcare Obstetric in PrEgnancy) model that is tailored to pregnancy data. We carried out a dataset extraction and construction process based on collections of health documents related to breastfeeding, childcare, pregnant care, nutrition, risks, vaccines, exams, and physical exercises. We evaluated two pre-trained models in the Portuguese language for the conversational agent architecture proposal and chose the one with the best performance to compose the HoPE architecture. The BERTimbau model, which has been trained on data augmentation strategies, proves to be able to retrieve information quickly and most accurately than others. For the fine-tuning process, we achieved a Spearman correlation of 95.55 on BERTimbau augmented with a few pairs (1.500 pairs). The HoPE model architecture achieved an F1-Score of 0.89, outperforming other combinations tested in this study. We will evaluate this approach for clinical studies in future studies.Mitochondria are essential for cardiac myocyte function, but damaged mitochondria trigger cardiac myocyte death. Although mitophagy, a lysosomal degradative pathway to remove damaged mitochondria, is robustly active in cardiac myocytes in the unstressed heart, its mechanisms and physiological role remain poorly defined. We discovered a critical role for TRAF2, an innate immunity effector protein with E3 ubiquitin ligase activity, in facilitating physiological cardiac myocyte mitophagy in the adult heart, to prevent inflammation and cell death, and maintain myocardial homeostasis.This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.Bleeding associated with left ventricular assist device (LVAD) implantation has been attributed to the loss of large von Willebrand factor (VWF) multimers to excessive cleavage by ADAMTS-13, but this mechanism is not fully supported by the current evidence. We analyzed VWF reactivity in longitudinal samples from LVAD patients and studied normal VWF and platelets exposed to high shear stress to show that VWF became hyperadhesive in LVAD patients to induce platelet microvesiculation. Platelet microvesicles activated endothelial cells, induced vascular permeability, and promoted angiogenesis in a VWF-dependent manner. Our findings suggest that LVAD-driven high shear stress primarily activates VWF, rather than inducing cleavage in the majority of patients.Surgical treatment of congenital heart defects affecting the right ventricular outflow tract often requires complex reconstruction and multiple reoperations. With a randomized controlled trial, we compared a novel tissue-engineered small intestine submucosa-based graft for pulmonary artery reconstruction (seeded with mesenchymal stem cells derived from Wharton's Jelly) with conventional small intestine submucosa in growing piglets. Six months after implantation, seeded grafts showed integration with host tissues at cellular level and exhibited growth potential on transthoracic echocardiography and cardiovascular magnetic resonance. Our seeded graft is a promising biomaterial for pulmonary artery reconstruction in pediatric patients with right ventricular outflow tract abnormalities.Environmental flow is the minimum flow required in a fluvial system to maintain its ecological health and to promote socio-economic sustainability. The present work critically examines the concept of the environmental flow in the context of dams and development using a systematic methodology to find out the previous works published during the last 3 decades (1990-2020) in different search engines and websites. The study reviews that structural interventions in the form of dams, barrages, weirs, etc. impede the natural flow of the rivers. Moreover, other forms of development such as industrialization, urbanization, and expansion of modern agriculture also exacerbate the problems of environmental flow across the world, especially in monsoon Asia. The present case of the environmental flow for the Damodar River portrays that the construction of dams and barrages under the Damodar Valley Project have significantly altered the flow duration, flood frequency, and magnitude (high-frequency low magnitude events in the post-dam period), while urban-industrial growth in the basin has polluted the river water (e.g., lower dissolved oxygen and higher biological oxygen demand). This typical alteration in the flow characteristics and water quality has threatened aquatic organisms, especially fish diversity and community structure. This review will make the readers aware of the long-term result of dam-induced fluvial metamorphosis in the environment through the assessment of environmental flow, species diversity, flow fluctuation, and river pollution. The study may be useful for policy-making for ushering in the sustainable development pattern that will attract future researchers, planners, and stakeholders.Acute respiratory infections due to viral or bacterial etiology can cause 60 deaths per one lakh population. Viral etiology is more common as compared to bacterial, but lack of definite diagnosis leads to increased usage of empirical antibiotics. selleck During the first wave of the COVID-19 pandemic, there was a need to identify co-infections especially in severe acute respiratory illness (SARI) patients to identify it as one of the cofactors for increased severity of illness and to identify the causative agents in COVID-19 negative individuals. The SARS CoV-2 real time PCR was carried out using ICMR approved kits and the other respiratory viruses were detected using the multiplex commercially available real time kit. A total of 186 patients presenting with either SARI (89.8%) or influenza like illness (10.2%) were included in the study. Out of these, 43 (23.1%) were positive for SARS CoV-2 RNA and 2 (4.6%) patients with SARI showed concomitant infection with either human rhinovirus or human respiratory syncytial virus . Out of 143 patients negative for SARS CoV-2, 35 (24.5%) were positive for one or more microbial infections and 28 (19.6%) infected with other respiratory viral infection most common being human rhinovirus. The results suggest that viral coinfections are significantly higher among COVID-19 negative individuals (24.5% vs 4.6%) presenting with respiratory illness as compared to COVID-19 positive individuals possibly due to viral interference and competitive advantage of SARS-CoV-2 in modulating the host immunity. Further detailed research is required for the understanding of mechanisms of viral co-infection.