Hussainespensen2956

The model results suggest As-hazard potential in yet-undetected areas. Our model performed well in predicting groundwater arsenic, with accuracy 82% and 84%; area under the curve (AUC) 0.89 and 0.88 for test data and validation datasets. An estimated ~90 million people across India are found to be exposed to high groundwater As from field-observed data, with the five states with highest hazard are West Bengal (28 million), Bihar (21 million), Uttar Pradesh (15 million), Assam (8.6 million) and Punjab (6 million). However it can be much more if the modeled hazard is considered (>250 million). Thus, our study provides a detailed, quantitative assessment of high groundwater As across India, with delineation of possible intrinsic influences and exogenous forcings. The predictive model is helpful in predicting As-hazard zones in the areas with limited measurements.Livestock production is a large source of microbial, pharmaceutical, and antimicrobial pollution worldwide. LAQ824 Vultures are one group of birds with particularly high exposure to food-borne pathogens due to frequent consumption of infected livestock carcasses. The potential origin and spatial-temporal shedding patterns of livestock-adapted Salmonella serotypes of zoonotic importance were evaluated in adult and nestling Griffon vultures (Gyps fulvus). We specifically assessed the exposure source and subsequent elimination of Salmonella-infected carcasses (ecosystem services) or transmission back to livestock (ecosystem disservices) by vultures, thus contributing respectively to disease mitigation or amplification in natural and farmed environments. The results show a seasonal high occurrence and turnover of a high variety of serotypes, especially swine-adapted ones isolated at high frequency. This suggests that vultures can be reservoirs and long-distance carriers of faecal Salmonella shed in supplementary feedingd their ecological function as cleaners and disease mitigators.Perfluoroalkyl substances (PFAS) are contaminants that are applied in a wide range of consumer products, including ski products. The present study investigated the neuro-dopamine (DA) and cellular steroid hormone homeostasis of wild Bank voles (Myodes glareolus) from a skiing area in Norway (Trondheim), in relation to tissue concentrations of PFAS. We found a positive association between brain DA concentrations and the concentration of several PFAS, while there was a negative association between PFAS and dopamine receptor 1 (dr1) mRNA. The ratio between DA and its metabolites (3,4-dihydroxyphenylacetic acid DOPAC and homovanillic acid HVA) showed a negative association between DOPAC/DA and several PFAS, suggesting that PFAS altered the metabolism of DA via monoamine oxidase (Mao). This assumption is supported by an observed negative association between mao mRNA and PFAS. Previous studies have shown that DA homeostasis can indirectly regulate cellular estrogen (E2) and testosterone (T) biosynthesis. We found no association between DA and steroid hormone levels, while there was a negative association between some PFAS and T concentrations, suggesting that PFAS might affect T through other mechanisms. The results from the current study indicate that PFAS may alter neuro-DA and steroid hormone homeostasis in Bank voles, with potential consequences on reproduction and general health.PM2.5 pollution has harmed the health and social lives of residents, and although evidence of PM2.5 pollution caused by human activities has been reported in a large body of literature, traditional econometric and spatial models can explain the contribution of a given factor from only a global perspective. Given this limitation, this study quantitatively investigated the effects of the spatiotemporal heterogeneity of various socioeconomic factors on PM2.5 pollution in 273 Chinese cities from 2010 to 2016 by exploratory spatial data analysis (ESDA) and geographically weighted regression (GWR). The spatiotemporal distribution pattern and intrinsic driving mechanism of city-level PM2.5 pollution were systematically examined. The results indicate the following (1) The cities with high PM2.5 pollution are located north of the Yangtze River and east of the Hu line. A notable positive spatial correlation was observed between these cities, and nearly one-third of the cities are in the HH clustering area. (2) From the global regression point of view, population size and economic development are the main factors causing the deterioration and spread of PM2.5 pollution in Chinese cities, and population size undoubtedly exerts the strongest influence. Industrial structure, economic development, openness degree, urbanization and road intensity also play weak roles in promoting urban PM2.5 pollution. (3) The socioeconomic factors influencing pollution exhibit significant spatial heterogeneity. Specifically, the cities in which pollution is promoted by economic development are mainly concentrated in the northeast and western regions. The cities in which population size exerts a positive driving effect are in most regions, except for a few central and western cities. Three targeted strategies for developing more sustainable cities are comprehensively discussed by building on the understanding of the socioeconomic driving mechanism for PM2.5 pollution.Pesticides are increasingly recognised as a threat to freshwater biodiversity, but their specific ecological effects remain difficult to distinguish from those of co-occurring stressors and environmental gradients. Using mesocosms we examined the effects of an organophosphate insecticide (malathion) on stream macroinvertebrate communities concurrently exposed to a suite of stressors typical of streams in agricultural catchments. We assessed the specificity of the SPEcies At Risk index designed to determine pesticide effects in mesocosm trials (SPEARmesocosm). This index determines the log abundance proportion of taxa that are considered physiologically sensitive to pesticides. Geographic variation in pesticide sensitivity within taxa, coupled with variation between pesticides and the effects of co-occurring stressors may decrease the accuracy of SPEARmesocosm. To examine this, we used local pesticide sensitivity assessments based on rapid toxicity tests to develop two new SPEAR versions to compare to the original SPEARmesocosms index using mesocosm results.