Rodriquezholcomb4843

The aim of this study is to understand individual motivation to speak up, which extends the application of voice behavior. Employing a cross-level moderation framework, this paper explored the relationship between employees' authoritarian leadership perceptions and their speaking-up behavior, as reported by supervisors, along with a moderating effect of group loyalty. Specifically, we propose a conceptual variable, "saying nothing but good news", which related to the choice of the selective disclosure of information to others. Utilizing data of 140 supervisors and 603 subordinates in the Taiwanese military, results of the hierarchical linear modeling (HLM) analysis revealed that authoritarian leadership was negatively related to prohibitive voice, but positively related to saying nothing but good news. Group loyalty moderated the relationship between authoritarian leadership and prohibitive voice when group loyalty is high. Implications for management and future research are discussed.Former US President Donald Trump's 2016 election victory defied expectations. Trump was an unconventional candidate, and his presidency was true to form. What accounts for his popularity? Integrating work on narcissism with the dual-process motivational model of ideology, we propose that individuals higher in narcissism are more likely to adopt right-wing authoritarian and social-dominance oriented attitudes, which lead them to embrace socially and economically conservative policy positions, respectively. Thus, they are receptive to Trump's anti-immigration stance, a centerpiece of his political messaging from the campaign trail to the White House. The present study (N = 302) yielded results consistent with this analysis Right-wing authoritarianism and social-dominance orientation mediated the association between narcissism and Trump support, via social and economic conservatism and immigration attitudes. The study represents an initial test of a potentially generative framework on which future research can elaborate.The current study is an initial effort to investigate the value of neutralization theory to understand how, by what method, to what degree, and in what condition ingroup members defend their leader against charges of misconduct. We propose that ingroup members use neutralizing techniques to defend their leaders in the same way they would defend themselves. After exploring the underlying social identity theory driving the use of leader defense, we test our proposition by analyzing the Trump-Ukraine Impeachment Inquiry Republican Staff Report. Torin 1 mw Using content analysis, we determine the presence of neutralization techniques and classify those instances into specific neutralization categories proposed in the literature. Using a post-hoc analysis, we then explore under what conditions ingroup members use specific neutralization techniques in defense of an ingroup leader. Our study extends prior theory and research by examining the use of neutralization techniques in defense of an ingroup leader's alleged misconduct.Isothiazolinone (IT) biocides are potent antibacterial substances used as preservatives and disinfectants. These biocides exert differing biocidal effects and display environmental stability based upon chemical structure. In agreement with our recent study reporting that 2-n-octyl-4-isothiazolin-3-one (OIT) induced dysfunction of the blood-brain barrier (BBB), the potential adverse health effects of two IT biocides 1,2-benzisothiazolin-3-one (BIT) and 4,5-dichloro-2-n-octyl-isothiazolin-3-one (DCOIT) were compared using brain endothelial cells (ECs) derived from murine brain endothelial cell line (bEND.3). BIT possesses an unchlorinated IT ring structure and used as a preservative in cleaning products. DCOIT contains a chlorinated IT ring structure and employed as an antifouling agent in paints. Data demonstrated that DCOIT altered cellular metabolism at a lower concentration than BIT. Both BIT and DCOIT increased reactive oxygen species (ROS) generation at the mitochondrial and cellular levels. However, the effect of DCOIT on glutathione (GSH) levels appeared to be greater than BIT. While mitochondrial membrane potential (MMP) was decreased in both BIT- and DCOIT-exposed cells, direct disturbance in mitochondrial bioenergetic flux was only observed in BIT-treated ECs. Taken together, IT biocides produced toxicity in brain EC and barrier dysfunction, but at different concentration ranges suggesting distinct differing mechanisms related to chemical structure.

To characterise opinions about needing to undergo MRI within the population of current cochlear implant (CI) users.

Magnetic resonance imaging (MRI) of CI users is often associated with severe discomfort and magnet displacement.

A global online survey of 310 CI users was conducted between 22nd July and 13th September 2020.

Only 55% of respondents had been told whether their model of CI could undergo MRI. 31% of respondents considered MRI when deciding whether to receive a CI, and 28% when deciding which CI model to have. 64% reported concerns related to their CI if needing MRI compared to 29% reporting concerns unrelated to their CI. Willingness to undergo MRI reduced when considering magnet removal, splinting, bandaging, local anaesthesia, lasting discomfort, an inability to use their CI, or a reduction in image quality because of their CI. The single most influential factor was the possibility of damaging their CI (63%). 59% of respondents would consider minor surgery to upgrade their retaining magnet to one of a rotating design.

These findings highlight the heterogeneity of CI users' opinions about MRI.

We suggest several opportunities for improving the dissemination of current and accurate MRI-related information for CI users.

We suggest several opportunities for improving the dissemination of current and accurate MRI-related information for CI users.The number of psoriatic elderly patients is steadily increasing in the Western world, nevertheless they are frequently excluded from clinical trials and described as a high-risk group for adverse events.We conducted a retrospective multicentric study of DMF use in elderly (>65 years) psoriatic patients. DMF efficacy was evaluated up to 24 weeks by Psoriasis Area and Severity Index (PASI) score. We also evaluated drug maintenance and safety.Our study population included 81 elderly psoriatic patients treated with DMF up to 24 weeks. The PASI score at the baseline (week 0) ranged from 3,7-24 (mean ± SD, 9,8 ± 4,1), which changed after DMF administration to 4,3 ± 3,2 at week 16 and 2,7 ± 3,2 at week 24. Among 81 elderly psoriatic patients 59 (72,8%) adverse events were reported during the observation period. The most common were gastrointestinal complaints (n = 24, 29,6%) and flushes (n = 10, 12,3%). Lymphocytopenia (n = 10, 12,35%) was frequently observed.In daily practice, DMF seems to be efficacy and well tolerated in elderly psoriatic patients. link2 DMF may be a first-line systemic treatment option to manage elderly psoriasis, provided that also the long-term safety data are closely monitored, in particular lymphocytopenia.

Imiquimod cream may be used as a non-surgical treatment for lentigo maligna or as adjuvant therapy following excision to decrease the risk of recurrence.

To evaluate histologic and clinical factors associated with clinical clearance of lentigo maligna treated with imiquimod.

We performed a retrospective review of all patients diagnosed with lentigo maligna and treated with imiquimod between 1997 and 2019 at our academic institution.

We observed clinical clearance in 93% (66/71) of participants who received adjuvant imiquimod following surgery and 79% (19/24) in the primary non-surgical treatment group over a median of 38 months of follow-up. In the adjuvant therapy group, positive surgical margins were associated with a decreased rate of clinical clearance when compared to cases with close (<1 mm) margins or background melanocytic dysplasia (83.3

100%,

 = .01). The presence of an inflammatory response during treatment was associated with increased clearance (94.1

66.7%,

 = .02).

Adjuvant imiquimod treatment may decrease LM recurrence rates in cases with background melanocytic dysplasia or close margins. LM cases with positive surgical margins need close clinical follow-up given higher recurrence rates.

Adjuvant imiquimod treatment may decrease LM recurrence rates in cases with background melanocytic dysplasia or close margins. LM cases with positive surgical margins need close clinical follow-up given higher recurrence rates.Main protease (Mpro) of SARS-CoV-2 is a key CoV enzyme that plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for SARS-CoV-2 the new strain of coronavirus. In this study, we evaluated biologically active compounds present in medicinal plants as potential SARS-CoV-2 Mpro inhibitors, using a molecular docking study with Autodock Vina software. Top seven compounds Afzelin, Phloroglucinol, Myricetin-3-O- rutinosid Tricin 7-neohesperidoside, Silybin, Kaempferol and Silychristin among 50 molecules of natural Origin (Algerian Medicinal plants) were selected which had better and significantly low binding energy as compared to the reference molecule with binding affinities of -9.3, -9.3, -9, -8.9, -8.5, 8.3 and -8.3 kcal mol-1 respectively. Then, we analyzed the ADME properties of the best 7 ligands using the Web server SwissADME. Two of small molecules have been shown to be the ideal candidates for further drug development. Finally, the stability of the both compounds complexed with Mpro was validated through molecular dynamics (MD) simulation, they displayed stable trajectory (RMSD, RMSF) and molecular properties with consistent interaction profile in molecular dynamics simulations, moreover, Silybin could form more stable complex with Mpro than Silychristin.Communicated by Ramaswamy H. Sarma.The COVID-19 pandemic has already taken many lives but is still continuing its spread and exerting jeopardizing effects. This study is aimed to find the most potent ligands from 703 analogs of remdesivir against RNA-dependent RNA polymerase (RdRp) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus . link3 RdRp is a major part of a multi-subunit transcription complex of the virus, which is essential for viral replication. In clinical trials, it has been found that remdesivir is effective to inhibit viral replication in Ebola and in primary human lung cell cultures; it effectively impedes replication of a broad-spectrum pre-pandemic bat coronaviruses and epidemic human coronaviruses. After virtual screening, 30 most potent ligands and remdesivir were modified with triphosphate. Quantum mechanics-based quantitative structure-activity relationship envisages the binding energy for ligands applying partial least square (PLS) regression. PLS regression remarkably predicts the binding energy of the effective ligands with an accuracy of 80% compared to the value attained from molecular docking. Two ligands (L458059550 and L28126719083), which have more interactions with the target protein than the other ligands including standard remdesivir triphosphate, were selected for further analysis. Molecular dynamics simulation is done to assess the stability and dynamic nature of the drug-protein complex. Binding-free energy results via PRODIGY server and molecular mechanics/Poisson-Boltzmann surface area method depict that the potential and solvation energies play a crucial role. Considering all computational analysis, we recommend the best remdesivir analogs can be utilized for efficacy test through in vitro and in vivo trials against SARS-CoV-2.Communicated by Ramaswamy H. Sarma.