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0, an early post-test score of 51.5, and the late post-test revealed a score of 48.0. The anxiety test revealed median scores of 8.0 (pre-test), 6.0 (early post-test) and 6.0 (late post-test), respectively. The depression test reported median scores of 4.0 (pre-test), 5.0 (early post-test) and 6.0 (late post-test), respectively. The median well-being score difference observed between the beginning and the end of sessions is +2.13. The minimum satisfaction score observed is 3.50 out of 10, and the maximum is 10 out of 10. The median is between 7.00 and 10.00. CONCLUSIONS Art therapy sessions had an impact on patients' welfare. We also reported a trend towards amelioration of quality of life that could probably be confirmed in a larger population, and potentially with a different methodology. © 2020 S. Karger AG, Basel.Technologies enabling in vivo range verification during proton therapy are actively sought as a means to reduce the clinical safety margins currently adopted to avoid tumor underdosage. In this contribution, we applied the semi-empirical theory of radiation-induced vaporization of superheated liquids to coated nanodroplets. Nanodroplets are injectable phase-change contrast agents that can vaporize into highly echogenic microbubbles to provide contrast in ultrasound images. We exposed nanodroplet dispersions in aqueous phantoms to monoenergetic proton beams of varying energies and doses. Ultrasound imaging of the phantoms revealed that radiation-induced droplet vaporization occurred in regions proximal to the proton Bragg peak. A statistically significant increase in contrast was observed in irradiated regions for doses as low as 2 Gy and found to be proportional to the proton fluence. The absence of enhanced response in the vicinity of the Bragg peak, combined with theoretical considerations, suggest that droplet vaporization is induced by high linear energy transfer (LET) recoil ions produced by nuclear reactions with incoming protons. Vaporization profiles were compared to non-elastic cross sections and LET characteristics of oxygen recoils. Shifts between the ultrasound image contrast drop and the expected proton range showed a sub-millimeter reproducibility. These early findings confirm the potential of superheated nanodroplets as a novel tool for proton range verification. © 2020 Institute of Physics and Engineering in Medicine.Plasmonic nanostructure-based refractive index (RI) sensors are the core component of biosensor systems and play an increasingly important role in the diagnosis of human disease. However, the costs of traditional plasmonic RI sensors are not acceptable to everyone due to their expensive fabrication process. Here, a novel low-cost and high-performance visible-light RI sensor with a particle-on-film configuration was experimentally demonstrated. The sensor was fabricated by transferring annealed Au nanoparticles (NPs) onto a thin gold film with polymethyl methacrylate (PMMA) as a support. RI sensitivities of approximately 209 nm/RIU and 369 nm/RIU were achieved by reflection and transmission spectrum measurements, respectively. The high sensitivity is due to the strong plasmon-mediated energy confinement within the interface between the particles and the film. learn more The possibility of wafer-scale production and high working stability achieved by the transfer process, together with the high sensitivity to the environmental RI, provides an extensive impact on the realization of universal biosensors for biological applications. © 2020 IOP Publishing Ltd.Here, we successfully fabricated GO wrapped Ti/Co3O4NWs by electrophoretic deposition (EPD) based on the good dispersibility of GO in aqueous solution. Interestingly, GO can adhere to the surface of Co3O4NWs via ultrathin gossamer-like sheet, and the coverage and wrapping of GO on the surface of Co3O4NWs can be controlled by tuning the electrochemical deposition time and voltage. Our results also demonstrate that GO wrapped Co3O4 NWs had superior photoelectrochemical (PEC) activity for decolorization of dye (reactive brilliant blue KN-R) wastewater, mainly because the introduction of GO can tune oxygen evolution behavior, transportation of reactant and induced carriers, electrochemical active areas, and light-harvesting capability of Co3O4 NWs. Therefore,we anticipate that GO wrapped Ti/Co3O4 NWs could be considered as a promising photoanode for the treatment of organic pollutants in wastewater. © 2020 IOP Publishing Ltd.The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and 90Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence 90Y detection limit determined from contrast-to-noise ratios is 10 nCi for a 2 min exposure with a sensitive CCD camera and no filters. For quantitative performance, the values extracted from regions of interest on the images are linear within 5% of a straight line fit versus target activity for target activity of 70 nCi and above. The small branching ratio to decay with positron emission for 90Y also permits low-statistics PET imaging of the radionuclide. For PET imaging of the same phantom, with a small animal LSO detector-based scanner, the 90Y detection limit is approximately 3 orders of magnitude higher at 10 µCi. © 2020 Institute of Physics and Engineering in Medicine.In this study, a functioning and ventilated anthropomorphic phantom was further enhanced for the purpose of CT and MR imaging of the lung and liver. A deformable lung, including respiratory tract was 3D printed. Within the lung's inner structures is a solid region shaped from a patient's lung tumour and six nitro-glycerine capsules as reference landmarks. The full internal mesh was coated, and the tumour filled, with polyorganosiloxane based gel. A moulded liver was created with an external casing of silicon filled with polyorganosiloxane gel and flexible plastic internal structures. The liver, fitted to the inferior portion of the right lung, moves along with the lung's ventilation. In the contralateral side, a cavity is designed to host a dosimeter, whose motion is correlated to the lung pressure. A 4DCT of the phantom was performed along with static and 4D T1 weighted MR images. The CT Hounsfield units for the flexible 3D printed material were -500 - -400, for the polyorganosiloxane gel 50 - 120 and for the silicon 650 - 800.