Yusufadler0938

The manufacturing process was validated through the production of three exhibit batches of 180,000 tablets in the industrial GMP facility, and the ANN model was applied to successfully predict the in vitro dissolution, with a bias of approximately 5%. The product was then tested on two clinical studies (under fasting and fed conditions) and the criteria to demonstrate bioequivalence to the Reference Listed Drug were met. In this study, ANNs were successfully applied to support the establishment of drug specifications and limits for process parameters, bridging the formulation development with in vitro performance and the positive clinical results obtained in the bioequivalence studies.Automatic analysis of skin abnormality is an effective way for medical experts to facilitate diagnosis procedures and improve their capabilities. Efficient and accurate methods for analysis of the skin abnormalities such as convolutional neural networks (CNNs) are typically complex. Hence, the implementation of such complex structures in portable medical instruments is not feasible due to power and resource limitations. CNNs can extract features from the skin abnormality images automatically. To reduce the burden of the network for feature extraction, which can lead to the network simplicity, proper input color channels could be selected. In this paper, a pruning framework is proposed to simplify these complex structures through the selection of most informative color channels and simplification of the network. Moreover, hardware requirements of different network structures are identified to analyze the complexity of different networks. Experimental results are conducted for segmentation of images from two publicly available datasets of both dermoscopy and non-dermoscopy images. Simulation results show that using the proposed color channel selection method, simple and efficient neural network structures can be applied for segmentation of skin abnormalities.Objective Lead toxicity (plumbism) secondary to retained lead missiles in synovial joint spaces is a rare complication after gunshot injuries. Management of lead missiles in the intradiscal space regarding potential lead toxicity is less certain. Methods We reviewed the literature regarding lead toxicity secondary to intradiscal bullets particularly concerning incidence, management, and outcomes. Results A lack of high-quality published data precludes a meta-analysis from taking place. Only four reports of lead toxicity secondary to missiles in the intradiscal space have been published. Including an additional case presented in this report, our review of the literature has led us to make several management recommendations, largely based on both the available literature and our current report. Conclusions First, there is insufficient evidence for removing retained lead missiles solely to mitigate the risk of lead toxicity. Second, chelation therapy in addition to surgical removal of the lead source is a valuable adjunct in the perioperative period and should be undertaken with the assistance of medical toxicology. Third, a retained missile does not mandate a simultaneous stabilization procedure in lieu of other indications based on the data available at this time.Background Most articles describing the effect of the COVID-19 pandemic on neurosurgical services have been from developed countries. ND-630 We attempt to report our experience in carrying out neurosurgical services in Dr. Sardjito General Hospital, Yogyakarta, Indonesia, during the time of the pandemic. Methods To collect information on the effect of the pandemic in Indonesia and Yogyakarta, we gathered data from the Indonesian Ministry of Health online database for the national data and local government records for the local data (including records of Dr. Sardjito General Hospital Division of Neurosurgery). Results Compared to other countries, Indonesia has not been severely hit by the impact of COVID-19. To raise the understanding of the natural history of the pandemic, we grouped the period into four different phases Phase 1 (there was confirmed cases in Indonesia but no cases found in Yogyakarta), Phase 2 (the first case in Yogyakarta detected), Phase 3 (the time when the cumulative cases surpass its peak), and Phase 4 (the pandemic ends). At the time of this writing, we were still in Phase 2 and in this phase, we experienced a decrease in the number of emergency surgical procedures, from an average of 4 to 2.4 procedures per week. Moreover, the number of elective operations dropped from an average of 12 to 9 procedures per week. Conclusions A pandemic, such as COVID-19, reduces both inpatient and outpatient neurosurgical activities. A comprehensive plan can improve both utilization and safety of the neurosurgical staff.Pleomorphic Xanthoastrocytoma (PXA) is an uncommon central nervous system neoplasm with an overall favourable survival prognosis. Metastatic spread of PXA to the spinal cord and the cauda equina is rare and may have a different clinicopathological course. Treatment and prognostic outcomes, in this context, is not well defined. We discussed a case of a 30-year-old patient with known cerebral PXA presenting with metastatic spinal anaplastic PXA and present a literature analysis of treatment outcomes.Objective Treatment of unruptured intracranial arteriovenous malformations (AVMs) has become controversial since the ARUBA study was published in 2014. We sought to analyze changes in the demographics, clinical presentation and treatment strategies in two patient cohorts from the same institution separated by 40 years. Methods We retrospectively reviewed the electronic medical records for a consecutive series of patients with unruptured intracranial AVMs seen at the Mayo Clinic between 2003-2017 and compared them to a previously published historical cohort from the same institution, seen between 1974-1985. Results There were 273 patients in the contemporary cohort, of which discovery of the AVM was incidental in 123 (45.1%), a 3.5-fold increase compared to the 13.1% out of 168 patients in the historical cohort (P less then 0.0001). Consequently, the percentage of patients with seizures as the presenting symptom leading to the diagnosis of AVM decreased from 57.7% in the historical cohort to 28.9% in the contemporary one (P less then 0.