Gravgaardtrolle1604

good predictor of absence of infection.The present work emphasizes on the changes in the Red Sea and Dead Sea mixed waters physical properties including temperature, pH, dissolved oxygen, density, salinity and viscosity. It focuses on the impacts of changes in mixed water quality on the Dead Sea ecosystem and the current industrial activities. The pilot project site consisted of six water ponds (tanks) located next to Arab Potash Company point of intake about 100 m south of the Dead Sea shores. The Red Sea - Dead Sea water mixing was controlled and done based on the expected mixing ratios between Red Sea and Dead Sea waters to mimic the potential actual situation associated with Red Sea - Dead Sea project conduit. All measured properties of mixed water bodies in tanks 1 to 5 tend to behave differently from similar Dead Sea water (tank 6) properties. The properties variations depend on the rate of diluting the Dead Sea water by Red Sea water and rejected brine. The least altered physical properties were observed when the Red Sea concentrated brine was added to the Dead Sea water (tank 5). The obtained results show that transferring Red Sea water to Dead Sea would lead to dilution of Dead Sea brine and affects significantly the investigated mixed water physical properties. Water mixing project is expected to cease the halite precipitation phenomenon due to the development of stratification in the Dead Sea and halite dissolution. Based on the industrial needs for the Dead Sea brine with its current physical properties, it is recommended to add rejected brine only to the Dead Sea due to its minimal effect on physical properties variations.

Varicocele is one of the most common treatable causes of male infertility. However, the decision to perform varicocelectomy before starting a fertility program remains controversial. This study aimed to thoroughly review and analyze the benefit of varicocele repair and its impact on the success rate of a fertility program.

A systematic literature search was performed using MEDLINE, Cochrane Library, and Wiley Library. The primary outcome was the pregnancy rate, and the secondary outcomes were live birth rate and surgical sperm retrieval success rate. Outcomes were compared between men who underwent treatment for a varicocele and those that did not. The pooled analysis data are presented as odds ratios with 95% confidence intervals.

A total of 31 articles were included in the meta-analysis. The pregnancy rate was significantly higher in the treated group (odds ratio = 1.82; 95% confidence interval 1.37-2.41; P < 0.0001) along with the live birth rate (odds ratio = 2.80; 95% confidence interval 1.67-4.72; P = 0.0001). The further subgroup analysis revealed a higher pregnancy rate in treated men with azoospermia, subnormal semen parameters, and normozoospermia (P = 0.04, P = 0.0005, and P = 0.002, respectively), while the live birth rate was only significantly higher in the treated men with subnormal semen parameters and normozoospermia (P = 0.001 and P < 0.0001). Treated varicocele also led to a higher sperm retrieval rate in azoospermic patients (odds ratio = 1.69; 95% confidence interval 1.16-2.45; P = 0.006).

Varicocele repair increased the pregnancy and live birth rates regardless the semen analysis result, along with the sperm retrieval success rate in azoospermic men. Thus, varicocele repair may be beneficial prior to joining a fertility program.

Varicocele repair increased the pregnancy and live birth rates regardless the semen analysis result, along with the sperm retrieval success rate in azoospermic men. Thus, varicocele repair may be beneficial prior to joining a fertility program.This paper presents the reconfiguration of control circuit designed to control four-quadrant chopper placed in the variable speed drive system (VSDS)'s DC-link. The purpose of this design is to reduce the overall total harmonic distortion THD% of input current, and the ripple factor (RF) of the DC-link current in this system. Both of Grey Wolf Algorithm (GWO) & Particle Swarm Optimization (PSO) have been used to get the optimal parameters of proportional integral PI and proportional integral differential with filter PIDN controllers. The variable speed drive system and the proposed filter have been modeled in integration with the suggested algorithms to determine the optimal values of the controllers' parameters. The grey wolf algorithm GWO outperformed the PSO algorithm in term of reaching the optimum parameters in less number of iterations in both dynamic and static work conditions. Also, the time response of the system with GWO is better than with PSO.Head and neck squamous cell carcinomas (HNSCCs) are human malignancies associated with both genetic and environmental factors. MicroRNAs (miRNAs) as a group of small non-coding RNAs have prominent roles in the development of this kind of cancer. Expressions of several miRNAs have been demonstrated to be increased in HNSCC samples vs. non-malignant tissues. In silico prediction tools and functional analyses have confirmed the function of some miRNAs in the modulation of cancer-associated targets, thus indicating these miRNAs as onco-miRs. Moreover, numerous miRNAs have been down-regulated in HNSCC samples. Their targets mostly enhance cell proliferation or inhibit apoptosis. miRNAs signature has practical implications in the diagnosis, staging, and management of HNSC. Most notably, numerous miRNAs have been shown to alter response of tumor cells to anti-cancer drugs such as cisplatin and doxorubicin. Circulating levels of these small transcripts have been suggested as promising biomarkers for diagnosis of HNSCC. In the present manuscript, we sum up the available literature regarding the miRNAs signature in HNSCC and their role as diagnostic/prognostic biomarkers.Food intake and health are important component of agriculture. The contribution of these duo have a lot to say about the productivity of farmers in the nations of the world. The results presented here relied on data collected on households' food intake nutrition and health profile through multistage random sampling of 420 households selected from the Southwest, Nigeria using well-structured questionnaires. Descriptive statistics (percentage, frequency, mean) and inferential statistics (Logistic regression and Negative Binomial). The result shows that the farmers were ageing, given an average of (53 ± 11.44 years). The Logistic regression model of the effect of farming households food intake on health showed that gender of the households' head, marital states of the head, household food security and knowledge of nutrition significantly reduced the probability of reporting good health while the educational year(s) of the farmers, total cost of health and consumption of fruit increased it. In addition, the Negative Binomial Regression model, employed in the assessment of the effect of farming households' nutrition on health indicated that gender, marital status, and consumption of milk and total cost of health significantly increased day(s) incapacitated while the year(s) of education reduced it. #link# It was therefore concluded that diversity of food intake among the farmers was low. Ageing, education and large household size among others, were also identified as major problem among the rural farmers. link2 It was however recommended that considerable investment in human capital should be encouraged since food diversity and nutrition education enhances households' food intake and health status.Recently, the prevention of cardiovascular events has become one of the most important aims of diabetes care. Peroxisome proliferator-activated receptor (PPAR) agonists have been reported to have vascular protective effects. Here, we examined whether pemafibrate, a selective PPAR alpha agonist, attenuated neointima formation after vascular injury and vascular smooth muscle cell (VSMC) proliferation. We performed endothelial denudation injury in mice treated with a high-fat diet (HFD) or normal chow. Orally administered pemafibrate significantly attenuated neointima formation after vascular injury in HFD and normal chow mice. Interestingly, pemafibrate increased the serum fibroblast growth factor 21 concentration and decreased serum insulin concentrations in HFD mice. In https://www.selleckchem.com/products/ars-853.html , body weight was slightly but significantly decreased by pemafibrate in HFD mice. Pemafibrate, but not bezafibrate, attenuated VSMC proliferation in vitro. The knockdown of PPAR alpha abolished the anti-VSMC proliferation effect of pemafibrate. BrdU assay results revealed that pemafibrate dose-dependently inhibited DNA synthesis in VSMCs. Flow cytometry analysis demonstrated that G1-to-S phase cell cycle transition was significantly inhibited by pemafibrate. Pemafibrate attenuated serum-induced cyclin D1 expression in VSMCs. However, apoptosis was not induced by pemafibrate as assessed by the TUNEL assay. Similar to the in vitro data, VSMC proliferation was also decreased by pemafibrate in mice. These data suggest that pemafibrate attenuates neointima formation after vascular injury and VSMC proliferation by inhibiting cell cycle progression.

The devastating Syrian crisis has raised concern regarding the social acceptance of smoking especially with water pipe use becoming a growing epidemic. We aim to determine the prevalence of cigarette and water pipe smoking among university students, along with identifying the addictive behavior among university students.

A cross-sectional study was conducted at the Syrian Private University during World No-Tobacco Day, in Damascus, Syria during the war crisis. The survey consists of 4 sections socio-demographic information, Fagerström Test of Nicotine Dependence, attitude towards water pipes, and perspective about smoking. Data were analyzed using the Statistical Package for Sciences version 25.0 (SPSS Inc., United States.).

Of the 622 participants, 429 (69%) were males with a mean age of 21.3 ± 3.1 years. The prevalence of tobacco smoking was 320 (51.4%), 208 (23.8%) for cigarettes, and 112 (18.0%) for water pipe. Smoking was significantly higher among male non-medical university students. The majority were low to moderate dependent when assessed by the Fagerström Test of Nicotine Dependence.

This study showed a very high prevalence of smoking indicating the need for smoking cessation programs, access to effective quitting treatments, and mass media campaigns to diminish smoking among the youth.

This study showed a very high prevalence of smoking indicating the need for smoking cessation programs, access to effective quitting treatments, and mass media campaigns to diminish smoking among the youth.Several studies have documented the hypolipidemic effect of anthocyanin-rich plants in vitro and in vivo. The objective of this study was to elucidate the inhibitory activity of anthocyanin-rich fraction from Thai berries against fat digestive enzymes. The ability of Thai berries to bind bile acid, disrupt cholesterol micellization and the cholesterol uptake into Caco-2 cells was also determined. link3 The content of total phenolics, flavonoid and anthocyanin in Prunus domestica L. (TPE), Antidesma bunius (L.) Spreng, Syzygium cumini (L.) Skeels, and Syzygium nervosum A. Cunn. Ex DC was 222.7-283.5 mg gallic acid equivalents, 91.2-184.3 mg catechin equivalents, and 37.9-49.5 mg cyanidin-3-glucoside equivalents/g extract, respectively. The anthocyanin-rich fraction of all extracts inhibited pancreatic lipase and cholesterol esterase with the IC50 values of 90.6-181.7 μg/mL and 288.7-455.0 μg/mL, respectively. Additionally, all extracts could bind primary and secondary bile acids (16.4-36.6%) and reduce the solubility of cholesterol in artificial micelles (53.