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Reliability was assessed through composite reliability scores. Measurement invariance across subgroups was also assessed.

The original five-factor (i.e., emotional symptoms, conduct problems, peer problems, hyperactivity and prosocial behaviour) SDQ fit the data satisfactorily, demonstrated evidence of reliability, and was invariant across sex (male vs. female), age (children vs. adolescents) and survey language (English vs. French). The higher-order solution fit the data acceptably, and the three-factor solution did not fit the data well.

The original five-factor, parent-rated SDQ demonstrates evidence of factorial validity and reliability as a population measure of mental health difficulties among Canadian children and adolescents.

The original five-factor, parent-rated SDQ demonstrates evidence of factorial validity and reliability as a population measure of mental health difficulties among Canadian children and adolescents.

Few studies of the healthy immigrant effect (HIE) have examined the mental health outcomes of Canadian-born individuals on a national scale compared with immigrants by admission category. This study fills this gap by examining the self-reported mental health (SRMH) of immigrants by admission category and other immigration dimensions (e.g., source world region and duration since landing) and making comparisons with Canadian-born respondents to a population-based survey.

Based on four cycles (2011 to 2014) of the Canadian Community Health Survey (CCHS) linked to the Longitudinal Immigration Database (IMDB), odds ratios of high (i.e., excellent or very good) SRMH among Canadian-born respondents and IMDB-linked immigrants are compared using logistic regression. Among the IMDB immigrant population, high SRMH was also examined according to the above-mentioned immigration dimensions. Adjusted results were hierarchically controlled for age, sex, social and economic factors, and sense of belonging.

Age-sex adjusant category.

This study provides new evidence on differences in mental health between Canadian-born individuals and immigrants by various characteristics. Results support a deterioration of the HIE in SRMH and identify factors significantly associated with SRMH. This study can also serve as a baseline for further studies on the impact of COVID-19 on immigrants' mental health by immigrant category.A new stream salamander species, Batrachuperus daochengensissp. nov., from southwestern China, is described herein based on morphological and molecular evidence. Molecular phylogeny derived from the mitochondrial gene together with previous nuclear data revealed that B. daochengensissp. nov. is sister to B. yenyuanensis. The new species differs from all other species of the genus by the following combination of characters brown horny epidermis on tips of fingers and toes absent; tubercles on palms and soles absent; costal grooves 12; dorsal brown, mottled with blackish spots; fingers 2-3-4-1 in order of decreasing length; tips of longest digits of fore- and hindlimbs largely separated by one to two costal spaces when adpressed towards each other along sides of body. The new species is currently known in the central and southern Shaluli Mountains in southwestern China.Understanding dietary selection and feeding strategies is important for the conservation and management of endangered primate species. Here, we conducted a preliminary study on the diet and feeding behavior of endangered Shortridge's langurs ( Trachypithecus shortridgei) within the Drung River Valley (Dulongjiang) in southwestern China. The study site lies at a high latitude (N27°47.5') and elevation (1 900 m a.s.l.) and is characterized by substantial annual rainfall (2 745.1 mm). From August 2012 to September 2013, we observed five groups of langurs and analyzed their overall food composition and dietary variation in spring and autumn. To understand their dietary adaptations to the distinctive habitat of the Drung River Valley, we also compared the diet of Shortridge's langurs to that of other Trachypithecus species inhabiting different environments. Results indicated that T. shortridgei fed on 52 plant species, 23 of which each accounted for ≥1% of their annual feeding time. Their primary dietary componentdgei are likely a response to the distinctive Drung River Valley habitat. Therefore, conservation of the main food plants of this threatened species could be vital for its survival and conservation management.Methionine aminopeptidase 1 (MetAP1) is a target for drug discovery against many adversaries and a potential antileishmanial target for its role in N-terminal methionine processing. As an effort towards new inhibitor discovery against methionine aminopeptidase 1 from Leishmania donovani (LdMetAP1), we have synthesized a series of quinoline-based hybrids, that is (Z)-5-((Z)-benzylidine)-2-(quinolin-3-ylimino)thiazolidin-4-ones (QYT-4a-i) whose in vitro screening led to the discovery of a novel inhibitor molecule (QYT-4h) against LdMetAP1. The compound QYT-4h showed nearly 20-fold less potency for human MetAP1 and had drug-like features. Time-course kinetic assays suggested QYT-4h acting through a competitive mode by binding to the metal-activated catalytic site. Notably, QYT-4h was most potent against the physiologically relevant Mn(II) and Fe(II) supplemented forms of LdMetAP1 and less potent against Co(II) supplemented form. Surface plasmon resonance and fluorescence spectroscopy demonstrated high affinity of QYT-4h for LdMetAP1. Through molecular modelling and docking studies, we found QYT-4h binding at the LdMetAP1 catalytic pocket occupying both the catalytic and substrate binding sites mostly with hydrogen bonding and hydrophobic interactions which provide structural basis for its promising potency. These results demonstrate the feasibility of employing small-molecule inhibitors for selective targeting of LdMetAP1 which may find use to effectively eliminate leishmaniasis.The COVID-19 pandemic has forced our society to come face to face with complex issues that were once theoretical but are now being played out in real time. click here As data from the pandemic accumulates, it is clear that COVID-19 is impacting some parts of society more than others. Unfortunately, there is an almost complete overlap between COVID-19 risk factors and conditions that are already represented as health disparities, such as hypertension, diabetes, heart disease, lung disease and immune disorders. In this review, we discuss our current understanding of the physiological and pathophysiological pathways that link these diseases to COVID-19 outcome. An increased awareness of the factors underlying this issue, both societal and medical, is needed to understand the long-term implications and possible solutions needed going forward.