Brooksglover6607

The final step was repeated recursively until a 3D OCT scan of the patient was segmented.

This approach was tested in 50 patients with normal and with ocular pathological conditions. The segmentation was compared to a manually segmented ground truth. The results were verified by clinical retinal experts. Kaempferide cost Dice Similarity Coefficient (DSC), 95% bidirectional modified Hausdorff Distance (HD), Unsigned Mean Surface Position Error (MSPE), and Average Volume Difference (AVD) metrics were used to quantify the performance of the proposed approach. The proposed approach was proved to be more accurate than the current state-of-the-art 3D OCT approaches.

The proposed approach has the advantage of segmenting all the 12 retinal layers rapidly and more accurately than current state-of-the-art 3D OCT approaches.

The proposed approach has the advantage of segmenting all the 12 retinal layers rapidly and more accurately than current state-of-the-art 3D OCT approaches.

The study aims to carry out a bibliometric analysis of the research on magnet hospital from 1988-2020.

A statistical and visualization bibliometric analysis was conducted between February-May 2020.

The information was extracted from Web of Science by the topic advanced search strategy. HistCite-Pro, Excel, GunnMap, BibExcel and VOSviewer were used to extract, integrate and visualize the bibliometric information. Furthermore, the research contents of the core-authors were explored and summarized by reviewing all the published articles.

Articles (N=396) published in 107 journals were retrieved in the Web of Science from 1988-2020. The USA (N=319) and University of Pennsylvania (N=38) were the most productive country and institution respectively. Author co-citation and bibliographic-coupling network analysis identified that Aiken, Kramer, Laschinger, Schmalenberg, Lake and Johantgen were the major contributors and leaders in this field. According to the research content of the main contributors and keywouggestions for magnet hospital policy makers.

This study showed the most contributed countries, journals, institutions, authors and the main themes related to magnet hospital, which would help researchers find potential partners, optimize and deepen future research, such as enhancing the magnet hospital research in developing countries, improving the evidence-based research and considering the impact caused by different culture. Furthermore, this study can also give suggestions for magnet hospital policy makers.In the Women's Health Initiative (WHI), we investigated associations between baseline dual-energy X-ray absorptiometry (DXA) appendicular lean mass (ALM) and risk of incident fractures, falls, and mortality (separately for each outcome) among older postmenopausal women, accounting for bone mineral density (BMD), prior falls, and Fracture Risk Assessment Tool (FRAX® ) probability. The WHI is a prospective study of postmenopausal women undertaken at 40 US sites. We used an extension of Poisson regression to investigate the relationship between baseline ALM (corrected for height2 ) and incident fracture outcomes, presented here for major osteoporotic fracture (MOF hip, clinical vertebral, forearm, or proximal humerus), falls, and death. Associations were adjusted for age, time since baseline and randomization group, or additionally for femoral neck (FN) BMD, prior falls, or FRAX probability (MOF without BMD) and are reported as gradient of risk (GR hazard ratio for first incident fracture per SD increment) in ALM/height2 and mortality remain robust. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Sound information is transmitted by different subtypes of spiral ganglion neurons (SGN) from the ear to the brain. Selective damage of SGN peripheral synapses (cochlear synaptopathy) is widely recognized as one of the primary mechanisms of hearing loss, whereas the mechanisms at the SGN central synapses remain unclear. We report that different subtypes of SGN central synapses converge at different ratios onto individual target cochlear nucleus neurons with distinct physiological properties, and show biased morphological and physiological changes during age-related hearing loss (ARHL). The results reveal a new dimension in cochlear nucleus neural circuitry that systematically reassembles and processes auditory information from different SGN subtypes, which is altered during ageing and probably contributes to the development of ARHL. In addition to known cochlear synaptopathy, the present study shows that SGN central synapses are also pathologically changed during ageing, which collectively helps us better unroperties. Endbulbs degenerated during ageing in parallel with ARHL. Furthermore, the degeneration was more severe in non-calretinin-expressing synapses, which correlated with a gradual decrease in bushy neuron subpopulation predominantly innervated by these inputs. These synaptic and cellular changes were profound in middle-aged mice when their hearing thresholds were still relatively normal and prior to severe ARHL. Our findings suggest that biased AN central synaptopathy and the correlated shift in cochlear nucleus neuronal composition play significant roles in weakened auditory input and altered central auditory processing during ARHL.The central nucleus of the amygdala (CeA) is widely implicated as a structure that integrates both appetitive and aversive stimuli. While intrinsic CeA microcircuits primarily consist of GABAergic neurons that regulate amygdala output, a notable feature of the CeA is the heterogeneity of neuropeptides and neuropeptide/neuromodulator receptors that it expresses. There is growing interest in the role of the CeA in mediating psychopathologies, including stress and anxiety states and their interactions with alcohol use disorders. Within the CeA, neuropeptides and neuromodulators often exert pro- or anti- stress actions, which can influence anxiety and alcohol associated behaviours. In turn, alcohol use can cause adaptions within the CeA, which may render an individual more vulnerable to stress which is a major trigger of relapse to alcohol seeking. This review examines the neurocircuitry, neurochemical phenotypes and how pro- and anti-stress peptide systems act within the CeA to regulate anxiety and alcohol seeking, focusing on preclinical observations from animal models.