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This review provides a brief on lipid based drug delivery nanocarrier and the mechanisms by which lipids and lipidic excipients improve the oral absorption of drugs with poor aqueous solubility and also provides a viewpoint on the promising applications of lipidic nanoparticulate systems. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Heterocyclic compounds hold a huge and recognized place in the field of medicinal chemistry thanks to their multiple biological activities. Their synthetic pathways allow their easy and rapid access due to different bond forming methodologies and provide a huge amount of multi-functionalized compounds for drug delivery. The syntheses of heterocyclic compounds are today well known for the majority, described and reviewed in an extensive literature. In this review, we choose to gather and classify available information concerning the biological activities of quinoxaline-based compounds annulated at bond a containing one and more nitrogen atoms in the fused azole ring. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Gene-based therapy largely relies on the vector type that allows a selective and efficient transfection into the target cells with maximum efficacy and minimal toxicity. Although, genes delivered utilizing modified viruses transfect efficiently and precisely, these vectors can cause severe immunological responses and are potentially carcinogenic. A promising method of overcoming this limitation is the use of non-viral vectors, including cationic lipids, polymers, dendrimers, and peptides, which offer potential routes for compacting DNA for targeted delivery. Although non-viral vectors exhibit reduced transfection efficiency compared to their viral counterpart, their superior biocompatibility, non-immunogenicity and potential for large-scale production make them increasingly attractive for modern therapy. There has been a great deal of interest in the development of biomimetic chimeric peptides. Biomimetic chimeric peptides contain different motifs for gene translocation into the nucleus of the desired cells. They have motifs for gene targeting into the desired cell, condense DNA into nanosize particles, translocate the gene into the nucleus and enhance the release of the particle into the cytoplasm. These carriers were developed in recent years. This review highlights the stepwise development of the biomimetic chimeric peptides currently being used in gene delivery. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Many spinning patents and technologies have been explored to produce diverse types of nanomaterials for different applications. As a novel method, the blown bubble-spinning is a one-step process for fabrication of nanofibrous bundles. METHOD In this study, polyamide6/66(PA6/66) nanofibrous bundles filled with different concentrations of multi-walled carbon nanotubes (MWCNTs) were prepared by the blown bubble-spinning. The dispersion of MWCNT in nanofibers under different treatments was investigated and a detailed characterization focusing on the influence of the presence of MWCNT on the morphology, thermal property and electrical property was carried out. RESULTS The results showed that MWCNTs treated by Tween60 and ultrasonication were embedded in the PA6/66 nanofibers with uniform dispersion. In addition, it was observed that thermal stability and electrical conductivity of nanofibrous bundles increased with an increase in MWCNT content. CONCLUSION The PA6/66/MWCNT nanofibrous bundles fabricated by the blown bubble spinning have the great potential applications in sensors and supercapacitors. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND In recent decades, nanofiber-based materials have been considered as one of the top interesting fundamental materials for academic studies and practical applications. However, the electrospinning, as the most popular method for manufacturing nanofibers, is plagued by its low productivity. The first patent about electrospinning was emerged in 1934 and the needleless electrospinning is regarded as one of the most promising methods to realize the high throughput of nanofibers. METHODS This review compares the recent needleless spinning technologies from limited liquid surfaces to free liquid surfaces for improvement of nanofiber throughput. The aim of this review is to reveal the merits and drawbacks of recent methods in practical employment. The view focuses also on the future concern of the needleless electrospinning. RESULTS The current needleless electrospinning is featured with the properties 1) high throughput; 2) lower voltage supply for the stable spinning process; 3) narrow fiber diameter distribution, followed by the drawbacks of poor long-term spinning process and limitation of a good bonding of low voltage supply. CONCLUSION This review provides an update on needleless electrospinning methods for high throughput of nanofibers for industrial applications. Selleckchem PT2385 Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Africa is the world's most genetically diverse, second largest, and second most populous continent, with over one billion people distributed across 54 countries. With a 23% lifetime risk of stroke, Africa has some of the highest rates of stroke worldwide and many occur in the prime of life with huge economic losses and grave implications for the individual, family, and the society in terms of mental capital, productivity, and socioeconomic progress. Tackling the escalating burden of stroke in Africa requires prioritized, multipronged, and inter-sectoral strategies tailored to the unique African epidemiological, cultural, socioeconomic, and lifestyle landscape. The African Stroke Organization (ASO) is a new pan-African coalition that brings together stroke researchers, clinicians, and other health-care professionals with participation of national and regional stroke societies and stroke support organizations. With a vision to reduce the rapidly increasing burden of stroke in Africa, the ASO has a four-pronged focus on (1) research, (2) capacity building, (3) development of stroke services, and (4) collaboration with all stakeholders.