Bushbengtson2943
Poor sleep quality and depression remain understudied in patients implanted with a left-ventricular assist device (LVAD). This study aimed at describing sleep quality and depression pre and 6 months post LVAD implantation, examining the change in sleep quality and depression over time, and exploring the relationships among sleep quality and depression. An observational research design was used in this study involving 23 patients with LVADs. Patients' demographics, clinical characteristics, subjective and objective sleep data, and depression were collected pre and 6 months post-LVAD implantation hospitalization. Descriptive and inferential statistics were employed in data analysis. We found that poor sleep quality and depression were highly prevalent during pre and post LVAD. Comparing pre to post LVAD, there was a significant change in depression, sleep efficiency, and sleep quality. Differences between sleep quality and depression scores pre to post LVAD were negatively correlated, although there were positive correlations between depression sleep quality scores. These findings are fundamental to informing future research further to understand the sleep-depression phenomenon in the LVAD population. Research is needed to understand the mechanism of the phenomenon and identify.Breast cancer is the most common type of cancer that affects females globally. Radiotherapy is a standard treatment option for breast cancer, where one of its most significant limitations is radioresistance development. MicroRNAs (miRNAs) are small, non-protein-coding RNAs that have been widely studied for their roles as disease biomarkers. To date, several in vitro, in vivo, and clinical studies have reported the roles of miRNAs in regulating radiosensitivity and radioresistance in breast cancer cells. This article reviews the roles of miRNAs in regulating treatment response toward radiotherapy and the associating cellular pathways. We identified 36 miRNAs that play a role in mediating radio-responses; 22 were radiosensitizing, 12 were radioresistance-promoting, and two miRNAs were reported to promote both effects. A brief overview of breast cancer therapy options, mechanism of action of radiation, and molecular mechanism of radioresistance was provided in this article. A summary of the latest clinical researches involving miRNAs in breast cancer radiotherapy was also included.Evidence on the association between internet usage and incidence of depression remains mixed. We examined the associations between different categories of internet usage and developing clinical depression. We used data from the 2013 and 2016 waves of the Japan Gerontological Evaluation Study (JAGES) comprising 12,333 physically and cognitively independent adults aged ≥65 years. Participants were engaged in seven categories of internet usage communication with friends/family, social media, information collection about health/medicine, searching for medical facilities, purchase of drugs and vitamins, shopping, and banking. We found that internet use for communication had a protective influence on the probability of developing clinical depression defined as the Geriatric Depression Scale scores ≥5 or self-reported diagnosed depression. Our findings support the role of online communication with friends/family in preventing clinical depression among older people. Online communication could be particularly useful in the COVID-19 crisis because many families are geographically dispersed and/or socially distanced.
This study aimed to investigate the effects of drug holidays during summer vacations among children with attention deficit/hyperactivity disorder (ADHD) who were treated with methylphenidate in terms of ADHD symptoms and executive functions.
The study was a prospective cohort study that includes pre-treatment, post-treatment and post-drug holiday evaluations. ADHD symptom severity was evaluated with the Clinical Global Impression Scale (CGI), the Conners' Parental Rating Scale-Short Form (CPRS) and the Conners' Teacher Rating Scale- Short Form (CTRS). The Stroop Color Word Test- TBAG Form (SCWT) was used to evaluate executive functions. Fifty-one patients participated in the study according to the inclusion and exclusion criteria. Methylphenidate (MPH) was started at 0.5 mg/kg/day and titrated weekly to a maximum of 1.2 mg/kg/day. During the follow-up period, 22 (43.0%) of the patients stopped treatment.
Completion times for all SCWT subtests were significantly reduced after treatment (
< 0.001,
= 0.002,
< 0.001,
= 0.002,
< 0.001; respectively). Mean number of corrections in SCWT-3 and mean number of errors as well as corrections in SCWT-5 significantly reduced after treatment (
= 0.047,
= 0.005,
= 0.007; respectively). Mean number of corrections in SCWT-3 and mean number of errors in SCWT-5 increased significantly after drug holiday compared to post-treatment (
= 0.032 and
= 0.037; respectively).
Our results suggest that psychomotor speed and resistance to interference improved in children with ADHD receiving methylphenidate treatment. Drug holidays did not affect psychomotor speed while beneficial effects on resistance to interference were reduced with drug holidays.
Our results suggest that psychomotor speed and resistance to interference improved in children with ADHD receiving methylphenidate treatment. Drug holidays did not affect psychomotor speed while beneficial effects on resistance to interference were reduced with drug holidays.Mortality and morbidity due to suicides have been an ever-growing burden in India. find more The public response to the understanding of suicidal deaths and popular perceptions are heavily dependent on media discourse and reporting of such cases. Recently, the alleged death of a young Indian celebrity due to suicide in India led to a media debacle that quickly spurred into endless speculations and sensational reporting of the associated details. Incidents of high-profile suicide often cause varied perceptions, attitudes and beliefs related to the 'act' that can get further compounded by misinformation and media-portrayal of the same. Recent cross-sectional research by Raj et al. (2020) explores the adherence of Indian media reporting of suicides for a month after the celebrity-death. It reveals that more than 80% of the news articles deviate from the prevalent Press Council of India (PCI) and the World Health Organization (WHO) guidelines for media-reporting of suicides. With this study in the background, the commentary contextualizes its findings in the Indian socio-cultural scenario, reviews the influence of media on public attitudes toward suicide, and highlights the need for active media-public health collaboration as a part of a national suicide prevention strategy.
