Harringtonmunn7773

We detail context-specific responses for each kind of hope. By attending to these nuances, not only will the parent or guardian's perspective be heard but also the pediatrician's recommendation can strike a balance between advocating for their conception of good medicine and respecting the parent or guardian's beliefs. Copyright © 2020 by the American Academy of Pediatrics.Glucagon-like peptide-2 (GLP-2) agonists have therapeutic potential in clinical indications where the integrity of the intestinal mucosa or its absorptive function are compromised, such as in short bowel syndrome (SBS). Native hGLP-2, a 33-amino acid peptide secreted from the small intestine, contributes to nutritional absorption but its very short half-life due to enzymatic cleavage and renal clearance severely limits its therapeutic value. The GLP-2 analog teduglutide (Revestive®/Gattex®, Shire Inc) has been approved for use in SBS since 2012 but has a once-daily injection regimen. Pharmacokinetic (PK) and pharmacodynamic studies confirm that apraglutide, a novel GLP-2 analog, has very low clearance, long elimination half-life and high plasma protein binding compared with GLP-2 analogs teduglutide and glepaglutide. Apraglutide and teduglutide retain potency and selectivity at the GLP-2 receptor comparable to native hGLP 2 while glepaglutide was less potent and less selective. In rat intravenous PK studies, s of apraglutide will benefit patients by enabling a reduced dosing frequency and removing the need for daily injections. The American Society for Pharmacology and Experimental Therapeutics.The molecular mechanisms governing normal neurodevelopment are tightly regulated by the action of transcription factors. Repressor element 1 (RE1) silencing transcription factor (REST) is widely documented as a regulator of neurogenesis that acts by recruiting corepressor proteins and repressing neuronal gene expression in non-neuronal cells. The REST corepressor 1 (CoREST1), CoREST2, and CoREST3 are best described for their role as part of the REST complex. However, recent evidence has shown the proteins have the ability to repress expression of distinct target genes in a REST-independent manner. These findings indicate that each CoREST paralogue may have distinct and critical roles in regulating neurodevelopment and are more than simply "REST corepressors," whereby they act as independent repressors orchestrating biological processes during neurodevelopment. Copyright © 2020 Maksour et al.Perceptual performance in a visual task can be enhanced by simultaneous multisensory information, but can also be enhanced by a symbolic or amodal cue inducing a specific expectation. That similar benefits can arise from multisensory information and within-modality expectation raises the question of whether the underlying neurophysiological processes are the same or distinct. We investigated this by comparing the influence of the following three types of auxiliary probabilistic cues on visual motion discrimination in humans (1) acoustic motion, (2) a premotion visual symbolic cue, and (3) a postmotion symbolic cue. Using multivariate analysis of the EEG data, we show that both the multisensory and preceding visual symbolic cue enhance the encoding of visual motion direction as reflected by cerebral activity arising from occipital regions ∼200-400 ms post-stimulus onset. This suggests a common or overlapping physiological correlate of cross-modal and intramodal auxiliary information, pointing to a neural mechanism susceptive to both multisensory and more abstract probabilistic cues. We also asked how prestimulus activity shapes the cue-stimulus combination and found a differential influence on the cross-modal and intramodal combination while alpha power modulated the relative weight of visual motion and the acoustic cue, it did not modulate the behavioral influence of a visual symbolic cue, pointing to differences in how prestimulus activity shapes the combination of multisensory and abstract cues with task-relevant information. Copyright © 2020 Kayser and Kayser.Johnson and Degeling have recently enquired whether one health (OH) requires a comprehensive normative framework, concluding that such a framework, while not necessary, may be helpful. In this commentary, we provide a context for this debate, and describe how pragmatism has been predominant in the OH literature. We nevertheless argue that articulating a comprehensive normative theory to ground OH practice might clear existing vagueness and provide stronger guidance in relevant health dilemmas. A comprehensive theory will also be needed eventually to ground notions such as universal good. We, thus, call for the systematic articulation of a comprehensive, metaethical theory, concomitantly with already ongoing normative work. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.Animals used in biological research and testing have become integrated into the trajectories of modern biomedicine, generating increased expectations for and connections between human and animal health. Animal research also remains controversial and its acceptability is contingent on a complex network of relations and assurances across science and society, which are both formally constituted through law and informal or assumed. In this paper, we propose these entanglements can be studied through an approach that understands animal research as a nexus spanning the domains of science, health and animal welfare. We introduce this argument through, first, outlining some key challenges in UK debates around animal research, and second, reviewing the way nexus concepts have been used to connect issues in environmental research. Third, we explore how existing social sciences and humanities scholarship on animal research tends to focus on different aspects of the connections between scientific research, human health aer(s)) 2020. Linifanib Re-use permitted under CC BY. Published by BMJ.Complex I is the first enzyme involved in the mitochondrial electron transport chain. With more than 40 subunits of dual genetic origin, the biogenesis of complex I is highly intricate and poorly understood. We used Chlamydomonas reinhardtii as a model system to reveal factors involved in complex I biogenesis. Two insertional mutants, displaying a complex I assembly defect characterized by the accumulation of a 700 kDa subcomplex, were analyzed. Genetic analyses showed these mutations were allelic, with insertional mutations in the gene AMC1 (Cre16.g688900), encoding a low-complexity protein of unknown function. The complex I assembly and activity in the mutant was restored by complementation with the wild-type gene, confirming AMC1 is required for complex I biogenesis. The N-terminus of AMC1 targets a reporter protein to yeast mitochondria, implying that AMC1 resides and functions in the Chlamydomonas mitochondria. Accordingly, in both mutants, loss of AMC1 function results in decreased abundance of the mitochondrial nd4 transcript, which encodes the ND4 membrane subunit of complex I.