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The combination of immunorecognition and MS/MS detection in iMBS-MS/MS enhances the measurement's selectivity, which is demonstrated by the rapid differentiation between the marine toxin domoic acid (DA) and its structural analog kainic acid (KA), which cannot be achieved with the LFIA alone. Interestingly, this first-ever reported iMBS-MS/MS method is generic and can be adapted to include any other immuno-captured food contaminant, provided that monoclonal antibodies are available, thus offering a complementary confirmatory analysis approach to multiplex immunoassay screening methods. Moreover, thanks to its speed of analysis, iMBS-MS/MS can bridge the logistics gap between future large-scale on-site testings using LFIAs and classical time-consuming confirmatory MS analysis performed in official control laboratories.Advanced antibacterial methods are urgently needed to deal with possible infectious diseases. As promising alternatives to antibiotics, enzyme-mimic nanocatalysts face bottlenecks of low activities and indistinct catalytic mechanisms, which seriously restrict their development for anti-infection treatment. Herein, metastable copper sulfide (Cu2-xS) nanozymes with diversiform sizes and compositions were selected to adjust the electronic structure for enhancing enzyme-mimic activities. The as-synthesized large and thin nanoplates (L/TN nanoplates), with the stoichiometric ratio of Cu1.25S, were proven to possess the optimal peroxidase (POD)-mimic activity. Using quantum mechanics, it was theoretically revealed that the sulfur vacancies could alter the electronic structure of copper active sites and thus reduce the reaction energy barrier of H2O2 to·OH to promote the POD-mimic performance. Moreover, through enhanced enzyme-mimic activities, L/TN nanoplates achieved efficient depletion of glutathione and ascorbic acid for improving antibacterial performances. Further, synergizing with the NIR irradiation, the satisfactory destruction capability for bacteria and biofilm was achieved for L/TN nanoplates under an inflammatory level of hydrogen peroxide (50 μM). Altogether, this work provides a deeper understanding of geometrical and electronic properties-dependent antibacterial performance, and paves the way toward precise compositions and structures engineering of nanozymes.The rapidly developing wearable flexible electronics makes the development of high-performance flexible energy storage devices, such as all-solid-state supercapacitors (SCs), particularly important. Herein, we report the fabrication of CNTs/NiCoSe2 hybrid films on carbon cloth (CC) through a facile co-electrodeposition method based on flexible electrodes for all-solid-state SCs. The NiCoSe2 sheets grown on CNTs uniformly with a diameter of 50-100 nm act as the active materials. The CNTs in the hybrid films act as the scaffold to offer more deposition sites for NiCoSe2 and provide a conductive network to facilitate the transfer of electrons. Moreover, the one-step electrodeposition process avoids the usage of any organic binders. Benefiting from the high intrinsic reactivity and unique 3D architecture, the obtained CNTs/NiCoSe2 electrode delivers high specific capacity (218.1 mA h g-1) and satisfactory durability (over 5000 cycles). Remarkably, the CNTs/NiCoSe2//AC flexible all-solid-state (FASS) ASC provides remarkable energy density (112.2 W h kg-1) within 0-1.7 V and maintains 98.1% of its initial capacity after 10,000 cycles. In addition, this flexible ASC device could be fabricated at a large scale (5 × 6 cm2), and the LED arrays (>3.7 V) can be easily lighted up by three ASCs in series, showing its potential practical application.Intelligent drug delivery systems (DDSs) that can improve therapeutic outcomes of antitumor agents and decrease their side effects are urgently needed to satisfy special requirements of treatment of malignant tumors in clinics. Here, the fabrication of supramolecular self-assembled amphiphiles based on the host-guest recognition between a cationic water-soluble pillar[6]arene (WP6A) host and a sodium decanesulfonate guest (G) is reported. The chemotherapeutic agent doxorubicin hydrochloride (DOX) can be encapsulated into the formed vesicle (G/WP6A) to construct supramolecular DDS (DOX@G/WP6A). WP6A affords strong affinities to G to avoid undesirable off-target leakage during delivery. Nanoscaled DOX@G/WP6A is capable of preferentially accumulating in tumor tissue via enhanced permeability and retention (EPR) effect. After internalization by tumor cells, the abundant adenosine triphosphate (ATP) binds competitively with WP6A to trigger the disintegration of self-assembled vesicles with the ensuing release of DOX. In vitro and in vivo research confirmed that DOX@G/WP6A is not only able to promote antitumor efficacy but also reduce DOX-related systemic toxicity. The above favorable findings are ascribed to the formation of ternary self-assembly, which profits from the combination of the factors of the EPR effect and the ATP-triggered release.As 5G communication technology allows for speedier access to extended information and knowledge, a more sophisticated human-machine interface beyond touchscreens and keyboards is necessary to improve the communication bandwidth and overcome the interfacing barrier. However, the full extent of human interaction beyond operation dexterity, spatial awareness, sensory feedback, and collaborative capability to be replicated completely remains a challenge. Here, we demonstrate a hybrid-flexible wearable system, consisting of simple bimodal capacitive sensors and a customized low power interface circuit integrated with machine learning algorithms, to accurately recognize complex gestures. The 16 channel sensor array extracts spatial and temporal information of the finger movement (deformation) and hand location (proximity) simultaneously. Using machine learning, over 99 and 91% accuracy are achieved for user-independent static and dynamic gesture recognition, respectively. Our approach proves that an extremely simple bimodal sensing platform that identifies local interactions and perceives spatial context concurrently, is crucial in the field of sign communication, remote robotics, and smart manufacturing.Owing to the scarcity of Pt, low-cost, stable, and efficient nonprecious metal-based electrocatalysts that can be applied in a wide pH range for the hydrogen evolution reaction (HER) are urgently required. Herein, a highly efficient and robust HER catalyst that is applicable at all pH values is fabricated, containing isolated Co-single atomic sites anchored in the self-supported WO3 arrays grown on Cu foam. At a current density of 10 mA cm-2, the HER overpotentials are 117, 105, and 149 mV at pH values of 0, 7, and 14, respectively, which are significantly lower than those of the undoped WO3, suggesting superior electrocatalytic H2-evolution activity at all pH values. The catalyst also exhibits long-term stability over a wide pH range, particularly in an acidic medium over 24 h, owing to the excellent anticorrosion properties of WO3. Density functional theory calculations prove that the enhanced HER activity is attributed to the isolated Co sites because these optimize the adsorption energy of H* species on WO3. Moreover, the high electrical conductivity of Co-doped WO3 and the three-dimensional array structure supported on the porous metal support afford a catalyst with suitable HER kinetics to enhance the catalytic performance.For better investigating the complicated relationships between H2S and SO2, simultaneously detecting and visualizing them with good selectivity is crucial. However, most sensing mechanisms for H2S and SO2 probes are based on the addition reactions with the double bonds, which have no selectivity. In this work, by introducing an active triple bond into 4-dicyanovinyl-7-diethylamino-coumarin, we construct two unique sensors for not only distinguishing between H2S and SO2 but also sensing H2S and SO2 in a dual-ratiometric manner. Moreover, the modified sensor was successfully applied in living cells and zebrafish for discriminating H2S and SO2.Human immunodeficiency virus (HIV) can independently replicate in the central nervous system (CNS) causing neurocognitive impairment even in subjects with suppressed plasma viral load. The antiretroviral drug darunavir (DRV) has been approved for therapy of HIV-infected patients, but its efficacy in the treatment of HIV-associated neurological disorders (HAND) is limited due to the low penetration through the blood-brain barrier (BBB). Therefore, innovations in DRV formulations, based on its encapsulation in optically traceable nanoparticles (NPs), may improve its transport through the BBB, providing, at the same time, optical monitoring of drug delivery within the CNS. The aim of this study was to synthesize biodegradable polymeric NPs loaded with DRV and luminescent, nontoxic carbon dots (C-Dots) and investigate their ability to permeate through an artificial BBB and to inhibit in vitro matrix metalloproteinase-9 (MMP-9) that represents a factor responsible for the development of HIV-related neurological disorders. Biodegradable poly(lactic-co-glycolic) acid (PLGA)-based nanoformulations resulted characterized by an average hydrodynamic size less than 150 nm, relevant colloidal stability in aqueous medium, satisfactory drug encapsulation efficiency, and retained emitting optical properties in the visible region of the electromagnetic spectrum. The assay on the BBB artificial model showed that a larger amount of DRV was able to cross BBB when incorporated in the PLGA NPs and to exert an enhanced inhibition of matrix metalloproteinase-9 (MMP-9) expression levels with respect to free DRV. buy DFMO The overall results reveal the great potential of this class of nanovectors of DRV for an efficacious treatment of HANDs.Although low-cost, high-surface-area crystalline aluminosilicate zeolites have been recognized as promising adsorbents for the capture of volatile organic compounds (VOCs), their hydrophilic nature leads to a significant loss of performance owing to the ubiquitous presence of water vapor in the VOC stream. Herein, the aluminosilicate zeolites (i.e., mordenite and nanocrystalline β) are functionalized via a solvothermal post-treatment with methyl iodide as the grafting agent. The methyl groups are primarily attached to the zeolite internal surface via covalent bonding between internal bridging O and -CH3, as evidenced by multiple analysis data. The static isotherms and diffusional studies clearly reveal a remarkable decrease in both the rate of water adsorption and the water affinity due to the attachment of methyl groups to the micropore walls, thus enhancing the water tolerance compared to that of pristine zeolites. In addition, CH3I-functionalized zeolites are investigated as adsorbents for the removal of benzene under dry and humid conditions, and their performance is compared to that of CH3Si(-OCH3)3-functionalized zeolites, wherein the methyl groups have been grafted onto the external surface. The results demonstrate that, although the benzene adsorption capacity under dry conditions is decreased upon internal surface functionalization, the loss of VOC adsorption capacity in the presence of H2O vapor is effectively prevented. By contrast, external surface functionalization is ineffective for preventing the negative effects of moisture upon the benzene adsorption capacity. As a result, CH3I-functionalized zeolites exhibit superior dynamic adsorption performance for benzene at 318 K under humid conditions (relative humidity 80%), with a saturated adsorption capacity of 64.9 mg g-1. This work provides an easy strategy for tailoring the adsorption properties of aluminosilicate zeolites for adsorption/separation and other advanced applications.