Waughbass6513

All color parameters were affected by TIP color in all three regions in most samples (P less then 0.05). The effect of composite abutment shade was also significant in most cases (P less then 0.05). The effect of laminate material, abutment shade, and TIP color on the b* parameter was significant (P less then 0.001). The L* parameter was almost the same in the two zirconia and lithium disilicate ceramic groups. Conclusion The composite abutment shade, TIP color, and laminate material should be carefully selected to achieve optimal aesthetics in laminate veneers. Copyright© Dental Research Center, Tehran University of Medical Sciences.Objectives To evaluate the effect of ozone and two common denture cleansers on the surface hardness and bond strength of a silicone-based soft liner to acrylic denture base material. Materials and Methods Sixty cylindrical specimens were fabricated using heat-cured poly-methyl methacrylate denture base resin. Three millimeters of the material was ground from the midsection and filled with the soft liner. The resilient liner specimens (n=40) used for the hardness test were 10 mm in diameter and 5 mm in height. Cylindrical and disc-shaped samples were randomly divided into four groups (37°C distilled water, Corega® tablets, 0.5% sodium hypochlorite (NaOCl), and a home ozone generator). To simulate six months of denture cleansing clinically, samples were placed in their cleanser once a day for six months according to the manufacturer's instructions. All cylindrical specimens were placed under tension until failure in a universal testing machine at a crosshead speed of 5 mm/minute. For disc-shaped samples, hardness was measured using a Shore-A durometer. The results were analyzed using Kruskal-Wallis test, analysis of variance (ANOVA), and Tukey's post hoc test. Results The mean tensile bond strength was not significantly different among the studied groups (P>0.05). The mean hardness in the ozone and Corega tablet groups was significantly lower than that of the control and NaOCl groups (P less then 0.05). Conclusion The type of denture cleanser does not affect the tensile bond strength of silicone soft liners. Home ozone generators and cleansing tablets have less effect on the hardness of soft denture liners compared to 0.5% NaOCl. Copyright© Dental Research Center, Tehran University of Medical Sciences.Objectives This study aimed to assess the effect of application of two types of zirconia primers on repair bond strength of composite to zirconia ceramic. Materials and Methods In this in vitro, experimental study, 60 zirconia blocks were divided into five groups and subjected to the application of Z-Prime Plus (ZPP), Monobond Plus (MBP), Porcelain Bonding Resin (PBR), ZPP followed by PBR (ZPP+PBR) and MBP followed by PBR (MBP+PBR). They were then bonded to Z100 composite. The samples were then immersed in water at 37°C for 24 hours, thermocycled for 1000 cycles between 5-55°C and subjected to shear bond strength (SBS) test. The mode of failure was determined under a stereomicroscope and a scanning electron microscope (SEM). Results The mean bond strength was the highest in ZPP+PBR group followed by MBP+PBR, ZPP, PBR and MBP group (22.29±8.86, 15.75±2.81, 12.02±3.24, 3.60±2.92 and 2.92±1.78 MPa, respectively). The effects of type of zirconia primer and use/no use of PBR on SBS were significant (P less then 0.05). The frequency of adhesive failure in MBP and PBR groups was significantly higher than that in MBP+PBR and ZPP+PBR groups (P less then 0.05). The cohesive failure was significantly more frequent in ZPP+PBR group than in ZPP, MBP and PBR groups (P less then 0.05). Conclusion Simultaneous application of zirconia primer and PBR is the most efficient technique for repair of all-ceramic zirconia restorations with composite resin. Copyright© Dental Research Center, Tehran University of Medical Sciences.Objectives This study aimed to assess the dentin adaptability of a certain type of fluoride varnish, as a novel root canal sealer, in comparison with AH-Plus sealer. Materials and Methods Twenty-four extracted single-rooted, single-canal human permanent teeth with straight and fully formed roots and no internal calcification, resorption or cracks, were selected and decoronated such that the remaining root length was 14 mm in all teeth. Root canals were prepared using the Mtwo rotary file system according to the manufacturer's instructions and filled with gutta-percha and either AH-Plus (n=12) or fluoride varnish (n=12) via the lateral compaction technique. Each root was then sectioned at 4 and 8 mm distances from the apex for evaluation under a scanning electron microscope (SEM). The gap size between the sealer and dentin was measured. Statistical analysis was performed using the Kolmogorov-Smirnov test and t-test with the significance level set at 0.05. Results The mean gap size was 14.407±1.402 μm and 8.342±0.694 μm in the roots obturated with AH-Plus and fluoride varnish sealers, respectively. The t-test revealed a statistically significant difference (P less then 0.001) in this regard between the two groups. Conclusion Fluoride varnish, as a root canal sealer, has a superior adaptation to dentinal canal walls compared to the AH-Plus sealer. Copyright© Dental Research Center, Tehran University of Medical Sciences.Pain is a constant symptom of dentin hypersensitivity (DH), which is a common condition that affects daily life and negatively affects the quality of life (QoL). Diagnosis and outcome measurements following the treatment of the disease require accurate pain assessment. The definition of pain underlies the complexity of its measurement as different factors modulate daily experience. The reproducibility of the prescribed stimuli for inducing DH pain clinically is difficult to achieve. This pain mevaasurement is made with unidimensional scales that are inadequate to capture the other dimensions of pain. The only specific QoL tool available for DH still requires testing in other populations and cultures. This article reviews the appropriateness of the current methods of DH pain assessment and the tools that consider the other pain dimensions. It also looks at its impact on the oral health-related quality of life (OHRQoL) of people with DH. The findings will create interest and facilitate research in this field of DH pain measurement and management. Copyright© Dental Research Center, Tehran University of Medical Sciences.Increasingly large observational datasets from healthcare and social media may allow new types of causal inference. However, these data are often missing key variables, increasing the chance of finding spurious causal relationships due to confounding. While methods exist for causal inference with latent variables in static cases, temporal relationships are more challenging, as varying time lags make latent causes more difficult to uncover and approaches often have significantly higher computational complexity. To address this, we make the key observation that while a variable may be latent in one dataset, it may be observed in another, or we may have domain knowledge about its effects. We propose a computationally efficient method that overcomes latent variables by using prior knowledge to reconstruct data for unobserved variables, while remaining robust to cases when the knowledge is wrong or does not apply. On simulated data, our approach outperforms the state of the art with a lower false discovery rate for causal inference. On real-world data from individuals with Type 1 diabetes, we show that our approach can discover causal relationships involving unmeasured meals and exercise.Objective Klotho and Fibroblast Growth Factor (FGF)-23 were recently postulated as candidate biomarkers and/or therapeutic targets in acute kidney injury (AKI). We examined whether urine Klotho and serum intact FGF23 levels were differentially and independently associated with major adverse kidney events (MAKE) in critically ill patients with and without AKI. Design Single-center, prospective, case-control study. Setting ICU in a tertiary medical center. Patients 54 AKI patients and 52 controls without AKI admitted to the ICU. Interventions None. Measurements and Main Results AKI was defined by KDIGO criteria and included only AKI stage ≥2. Controls were matched by age, gender, and baseline eGFR. Paired serum and urine samples were obtained 24-48h after AKI diagnosis (cases) or ICU admission (controls). selleckchem The primary outcome was 90-day MAKE, which was the composite of all-cause death, dependence on renal replacement therapy or a 50% or higher decrease in eGFR from baseline. Forty-four (41.5%) patients developeds of renal outcomes in the ICU.Here we describe a method based on Liquid Chromatography coupled with Mass Spectrometry (LC-MS) that provides an accurate determination of the six main bovine milk proteins, including allelic and splicing variants, as well as isoforms resulting from post-translational modifications, with an unprecedented level of resolution. Proteins are identified from observed molecular masses in comparison with theoretical masses of intact proteins indexed in an "in-house" database that includes nearly 3000 entries. Quantification was performed either from UV (214 nm) or mass signals. Thus, up to one hundred molecules, derived from the six major milk proteins, can be identified and quantified from an individual milk sample. This powerful and reliable method, initially developed as an anchoring method to estimate the composition of the six main bovine milk proteins from MIR spectra, is transferable to several mammalian species, including small ruminants, camels, equines, rabbits, etc., for which specific mass databases are available. © 2020 Published by Elsevier Ltd.Background Trigeminal neuralgia (TN) is a painful disorder characterized by sudden electric shock-like pain. It is a rare condition for which multiple treatments are available, including medical and surgical. The best treatment option is yet to be defined, and this is related to the lack of definition in the treatment outcomes and outcome measures. The aim of this systematic review was to summarize all the outcomes and outcomes measures that have been published to date and highlight variability in their use. Methods We have conducted a literature search using a wide range of databases (1946-2019 for medical and 2008-2019 for surgical treatment), for all intervention studies in TN. Four hundred and sixty-seven studies were selected for data extraction on TN classification, data collection method, intervention, and treatment outcomes mapped to the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT guidelines). Results Most studies collected data on pain (n = 459) and side effects (n = 386) domains; however, very few collected data on the impact of treatment on physical (n = 46) and emotional functioning (n = 17) and on patient satisfaction (n = 35). There was high variability on outcome measures used for pain relief (n = 10), pain intensity (n = 9), and frequency of pain episodes (n = 3). Conclusions A clear definition of what are the important outcomes for patients with TN is essential. The choice of standardized outcome measures allowing for consistent reporting in TN treatment will allow for comparison of studies and facilitate treatment choice for patients and clinicians thus, improving health outcomes and reducing health care cost. © 2020 The Authors.