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017 and p = .02, respectively). A reverse left ventricular remodeling (i.e., reduction on LV end-diastolic diameter and end-diastolic volume) was achieved only in the disproportionate FMR group.

In conclusion, disproportionate FMR assessed by regurgitant fraction and RV dysfunction assessed by TAPSE may help the selection of HF patients candidates for MitraClip therapy.

In conclusion, disproportionate FMR assessed by regurgitant fraction and RV dysfunction assessed by TAPSE may help the selection of HF patients candidates for MitraClip therapy.Inferior vena cava (IVC) filters have existed as a treatment option for VTE for decades. Advances in medical technology have provided physicians with several options for devices that can be placed on either a permanent or temporary basis; however, there are limited data from randomized, controlled trials on the appropriate use of IVC filters. This contemporary review summarizes the history of IVC filters and the types that are available in clinical practice. It reviews the literature on the use of IVC filters and discusses the indications that professional societies have endorsed for their use. In addition, it outlines the complications of IVC filter placement and future research directions.Leptin is a pleotropic hormone known to regulate a wide range of systemic functions, from satiety to inflammation. Increasing evidence has shown that leptin and its receptor (ObR) are not only expressed in adipose tissue but also in several organs, including the lungs. Leptin levels were first believed to be elevated only in the lungs of obese patients, and leptin was suspected to be responsible for obesity-related lung complications. Aside from obesity, leptin displays many faces in the respiratory system, independently of body weight, as this cytokine-like hormone plays important physiological roles, from the embryogenic state to maturation of the lungs and the control of ventilation. The leptin-signaling pathway is also involved in immune modulation and cell proliferation, and its dysregulation can lead to the onset of lung diseases. This review article addresses the thousand faces of leptin and its signaling in the lungs under physiological conditions and in disease.

To examine the association of apolipoproteins with arterial stiffness and carotid artery structure in children and adolescents.

A total of 338 children and adolescents (178 female) with a mean age 13.0±2.8years were examined. Apolipoproteins (AI, AII, B

, CII, CIII, and E) were measured via human apolipoprotein magnetic bead panel. Applanation tonometry determined pulse wave velocity and ultrasound imaging measured carotid intima-media thickness. selleckchem Dual X-ray absorptiometry measured total body fat percent. Linear regression models were adjusted for Tanner stage, sex, and race with further adjustments for body fat percent. Linear regression models also examined the interaction between Tanner stage and apolipoproteins.

There was a significant positive association between pulse wave velocity and apolipoproteins AI (0.015m/s/10μg/mL [CI 0.005-0.026], P=.003), AII (0.036m/s/10μg/mL [0.017-0.056], P<.001), B

(0.009m/s/10μg/mL [0.002-0.016], P=.012), E (0.158m/s/10μg/mL [0.080-0.235], P<.001), and CIIICers of cardiovascular risk.

To establish continuous reference intervals for TSH by data mining, using quantile regression with restricted cubic splines model.

TSH results (n=13,333) were collected for a four years period (between March 2015 and February 2020). After an exclusion step, TSH results (n=8838) were used to derive continuous reference intervals (i.e. 2.5th and 97.5th percentiles) spanning 18-90years of age, using quantile regression with restricted cubic splines (RCS) model, then compared to age-partitioned reference intervals generated by Bhattacharya analysis.

Despite similar reference intervals to the Bhattacharya analysis, continuous reference intervals appeared to give a more accurate and consistent estimation of the upper reference limits (i.e.97.5

percentiles) with complex age-related variations in serum TSH concentrations.

Our results suggest that quantile regression with RCS model appears to be a very useful tool available for clinical laboratories to establish local continuous TSH reference intervals.

Our results suggest that quantile regression with RCS model appears to be a very useful tool available for clinical laboratories to establish local continuous TSH reference intervals.

There is an emerging realisation that paediatric reference intervals (RIs) estimated using discrete age-groups may be misleading, especially close to age cut-off values. This limitation has been addressed by estimating RIs that vary continuously with age. This systematic review examines the range of statistical methods used over the past 25years for estimation of age-specific RIs, and identifies trends in usage and reporting.

Literature searches were conducted using predefined search criteria for original publications between 1993 and 2018 on the MEDLINE and Embase databases. Data related to sample size, treatment of age (as categorical or continuous), and statistical methods were extracted from the selected publications.

A total of 238 publications were reviewed. Not all publications reported the statistical methods used in different steps. Among the publications, 167 (70%) reported discrete age-group RIs, 54 (23%) reported continuous RIs and 17 (7%) reported both types of RIs. The nonparametric statistical method was commonly used for discrete age-group RIs (64%, n=117), whereas a wide variety of curve-fitting approaches, including Cole's lambda-mu-sigma method (28%, n=20), parametric curve-based methods (28%, n=20), generalised additive model for location, scale and shape method (13%, n=9) and quantile regression (11%, n=8) were used for continuous RIs.

Improvement in the reporting of statistical methods used for estimating age-specific paediatric RIs is required. There has been insufficient uptake of methods for producing continuous RIs, especially for biomarkers that display strong age-dependence.

Improvement in the reporting of statistical methods used for estimating age-specific paediatric RIs is required. There has been insufficient uptake of methods for producing continuous RIs, especially for biomarkers that display strong age-dependence.