Mckenziehutchison2991

Dapone and atovaquone are therapeutic options for PJP prophylaxis in renal transplant recipients. The objective of this study was to evaluate the incidence of anemia in renal transplant recipients receiving these agents.

This is an IRB-approved, retrospective analysis of adult renal transplant recipients who received either dapsone or atovaquone. The primary endpoint was the change in hemoglobin within 90days of drug initiation. Other endpoints of interest included incidence and management of anemia at multiple time points post-transplant. Categorical variables were compared with Pearson's chi-squared or Fischer's exact test and continuous data were compared utilizing Wilcoxon rank-sum test. Statistical analyses were performed using Stata 14.2.

A total of 478 patients were screened for inclusion; 50 patients were evaluated in both the dapsone and atovaquone groups. In the dapsone and atovaquone groups, the median age was 52 and 50.5years, 44% and 42% were Caucasian, and median time to treatment initiation was 27 and 39days post-transplant, respectively. All patients receiving dapsone had normal G6PD function. There was no difference in baseline hemoglobin between groups (9.7g/dL vs 9.8g/dL, P=.83). The median nadir hemoglobin values were 8.6g/dL and 9.6g/dL in the dapsone and atovaquone groups, respectively (P=.047). The median decrease in hemoglobin from baseline to nadir was 1.3g/dL in dapsone patients and 0.2g/dL in atovaquone patients (P=.001). Dapsone was discontinued in 46% of patients, whereas atovaquone was discontinued in 18% (P=.001).

Among renal transplant recipients with normal G6PD activity, dapsone is associated with greater hemoglobin reductions and rates of drug discontinuation as compared to atovaquone.

Among renal transplant recipients with normal G6PD activity, dapsone is associated with greater hemoglobin reductions and rates of drug discontinuation as compared to atovaquone.

This study aims to explore the prevalence rates of stigma and fear among people in Jordan during COVID-19 pandemic and to assess socio-demographic and personal factors contributing to the prevalence rates of fear and stigma among people in Jordan during COVID-19 pandemic.

Cross-sectional descriptive design was utilized to attain the study aim. An anonymous online survey targeting people of Jordan was used and distributed to adults in Arabic language. The survey included a previously validated fear scale. Stigma was measured using developed instrument by authors.

The prevalence of fear among study participants was 52%. In addition, the prevalence of stigma towards infected people and their contact was 64%. The predictors of stigma towards infected people with COVID-19 and their contact were income, living area and downloaded application to trace COVID-19 cases. Moreover the predictors of fear were income living area and downloaded application to trace COVID-19 cases (P≤ .001).

More than 50% of the respondents were afraid from COVID-19 and 64% had stigma towards infected people and their contact during the COVID-19 pandemic. The present study highlights the need for an intervention that provides psychological support to citizens during the pandemic.

More than 50% of the respondents were afraid from COVID-19 and 64% had stigma towards infected people and their contact during the COVID-19 pandemic. The present study highlights the need for an intervention that provides psychological support to citizens during the pandemic.

In this study, we aimed to investigate the clinical and demographic characteristics of asymptomatic COVID-19 cases incidentally diagnosed at the emergency department.

This study retrospectively analysed the medical data of patients who presented to the emergency department, between March 1 and May 1, 2020, without COVID-19 symptoms such as fever, cough, myalgia on admission but were incidentally detected to have thoracic computerised tomography (CT) findings suggestive of COVID-19. GSK1210151A inhibitor The patients' sociodemographic and epidemiological characteristics, laboratory test results, clinical and radiological findings, treatment protocols and prognoses were recorded.

We incidentally diagnosed COVID-19 pneumonia in 81 asymptomatic patients. All patients presented to the emergency department with traumatic injuries. Of these, 38 (46%) were injured in in-vehicle traffic accidents; 27 (34%) out-of-vehicle traffic accidents; 14 (18%) simple falls; and 2 (2%) falls from a height. Only 42 (48%) patients had a history of any patient without wearing PPE.

Early identification and isolation of asymptomatic patients are of great importance for reducing the speed of propagation of the COVID-19 pandemic. Incidentally diagnosed cases have made us consider that there is a need to increase the number of screening tests. We also believe that healthcare staff should suspect COVID-19 pneumonia in every patient irrespective of presentation type, place importance on the use of personal protective equipment (PPE), and not examine any patient without wearing PPE.Casein kinase I (CK1), a ubiquitous Ser/Thr protein kinase in eukaryotes, plays a critical role in higher plant flowering. Arabidopsis CK1 family member MUT9-LIKE KINASEs, such as MLK1 and MLK3, have been shown to phosphorylate histone H3 at threonine 3 (H3T3), an evolutionarily conserved residue, and the modification is associated with the transcriptional repression of euchromatic and heterochromatic loci. This study demonstrates that mlk4-3, a T-DNA insertion mutant of MLK4, flowered late, and that overexpression of MLK4 caused early flowering. The nuclear protein MLK4 phosphorylated histone H3T3 both in vitro and in vivo, and this catalytic activity required the conserved lysine residue K175. mutation of MLK4 at K175 failed to restore the level of phosphorylated H3T3 (H3T3ph) or to complement the phenotypic defects of mlk4-3. The FLC/MAF-clade genes, including FLC, MAF4 and MAF5, were significantly upregulated in mlk4-3. The double mutant mlk4-3 flc-3 flowered earlier than mlk4-3, suggesting that functional FLC is crucial for flowering repression in mlk4-3. Chromatin immunoprecipitation assays showed that MLK4 bound to FLC/MAF chromatin and that H3T3ph occupancy at the promoter of FLC/MAF was negatively associated with its transcriptional level. In accordance, H3T3ph accumulated at FLC/MAF in 35SMLK4/mlk4-3 but diminished in 35SMLK4(K175R)/mlk4-3 plants. Moreover, the amount of RNA Pol II deposited at FLC/MAF was clearly enriched in mlk4-3 relative to the wild type. Therefore, MLK4-dependent phosphorylation of H3T3 contributes to accelerating flowering by repressing the transcription of negative flowering regulator FLC/MAF. This study sheds light on the delicate control of flowering by the plant-specific CK1, MLK4, via post-translational modification of histone H3.