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Retraction of 'Swerchirin exerts anticancer activity on SKOV3 human ovarian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade', by Lan Luo, Haibo Zhao, Qian Luo, JBUON 2018;23(1)111-116; PMID29552769. Following the publication of the above article, readers drew to our attention that part of the data was unreliable. The authors were requested to provide the raw data to prove the originality, but were unable to do so. After an investigation, the Editors of JBUON decided to retract this article. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.In 19th century breast cancer was still an incurable disease. The treatment was consisting of surgical excision of the tumour, cautery iron and topical application of caustic substances such as arsenic and caustic potash without promising results. The French physician Louis Robert (1771-1850) adopted the leech method of François-Joseph-Victor Broussais (1772-1838) and proposed, for the first time, a method to prevent breast cancer. Despite the supposed success of his approach, the introduction of the notion of prevention and the ways to achieve it, it is meticulously analyzed in his work.The prediction of lymph node involvement represents an important task which could reduce unnecessary surgery and improve the definition of oncological therapies. An artificial intelligence model able to predict it in pre-operative phase requires the interface among multiple data structures. The trade-off among time consuming, expensive and invasive methodologies is emerging in experimental setups exploited for the analysis of sentinel lymph nodes, where machine learning algorithms represent a key ingredient in recorded data elaboration. click here The accuracy required for clinical applications is obtainable matching different kind of data. Statistical associations of prognostic factors with symptoms and predictive models implemented also through on-line softwares represent useful diagnostic support tools which translate into patients quality of life improvement and costs reduction.

Indocyanine green (ICG) is being used more and more in Urology along with advances in minimal invasive surgery, guiding excision and reconstruction, highlighting anatomic structures and functional features with oncologic guidance still being debatable. The purpose of this paper was to explore ICG use in urologic procedures.

We present our experience (37 cases) of using ICG fluorescence guidance in urologic operations performed using 3D laparoscopy and FireFly® fluorescence imaging mode of Da Vinci X robot. The operations were the following pelvic lymphadenectomy in radical prostatectomy, totally intracorporeal orthotopic ileal neobladder reconstruction, vesicovaginal fistula repair, partial nephrectomy and pyeloplasty. Barnard's test was used to compare postoperative complications (digestive fistula, ureteral stricture) for totally intracorporeal ileal neobladders performed with (group e, 27 cases) vs. without (group 2, 28 cases) ICG guidance.

ICG under near-infrared fluorescence offered a precise identses, with possible impact on perioperative complications, along with oncologic and functional postoperative outcomes.

To detect the expression level of HOTAIR in patients with papillary thyroid carcinoma (PTC) and further investigate its associations with the pathological stage, computed tomography (CT) characteristics and prognosis of these patients.

The expression level of HOTAIR was assessed in normal tissues and thyroid cancer tissues of PTC patients and nodular goiter tissues of patients with nodular goiter via reverse transcription-polymerase chain reaction (RT-PCR). Additionally, the relations of HOTAIR expression level with the clinicopathological features, CT characteristics and prognosis of PTC patients were analyzed. Finally, Western blotting was employed to detect the protein expression level of vascular endothelial growth factor (VEGF) in the normal tissues, thyroid cancer tissues and nodular goiter tissues.

The expression level of HOTAIR was notably higher in the thyroid cancer tissues than in the normal tissues and nodular goiter tissues (p<0.05). The high expression of HOTAIR was significantly correleased in PTC tissues and has a positive correlation with the pathological stage and poor prognosis of patients. HOTAIR can serve as a diagnostic or prognostic marker for patients with papillary thyroid carcinoma.

The expression level of HOTAIR is distinctly increased in PTC tissues and has a positive correlation with the pathological stage and poor prognosis of patients. HOTAIR can serve as a diagnostic or prognostic marker for patients with papillary thyroid carcinoma.

Renal cell carcinoma (RCC) is the most common renal neoplasm and accounts for 3% of all cancers. Increasing studies reported that miR-10a, acting as tumor suppressor, was downregulated in several cancers. It has been reported that the proteins encoded by Brain-Derived Neutrophic Factor (BDNF) were members of the nerve growth factor family, and could promote neuronal survival in the adult brain. The purpose of this study was to explore how miR-10a worked in RCC on the metastasis.

The expression level of miR-10a and BDNF were calculated using RT-PCR and western blot. Transwell assay was utilized to evaluate the invasive ability. Kaplan-Meier method along with log-rank test were applied to evaluate the 5-year overall survival of RCC patients.

miR-10a was significantly downregulated and BDNF was upregulated in RCC tissues and cell lines A498 and 786-O. The expression of miR-10a had a reverse correlation with BDNF in RCC tissues. Overexpression of miR-10a or interference of BDNF inhibited the invasion and epithelial-mesenchymal transition (EMT) of A498 cells. What's more, BDNF was demonstrated to be a target gene of miR-10a and miR-10a could mediate the expression of BDNF in RCC. In addition, low expression of miR-10a or overexpression of BDNF predicted poor prognosis of RCC patients.

Our results indicated that miR-10a inhibited the invasion and EMT by regulating BDNF in RCC. The newly identified miR-10a/BDNF axis provides novel insight into the pathogenesis of RCC.

Our results indicated that miR-10a inhibited the invasion and EMT by regulating BDNF in RCC. The newly identified miR-10a/BDNF axis provides novel insight into the pathogenesis of RCC.