Mcintoshdrake5837

In vivo direct drug targeting aims at delivering drug molecules loaded on microrobots to the diseased site using the shortest possible physiological routes, which potentially improves targeting efficiency and reduces systemic toxicity. It is thus essential to consider realistic in-body limitations for direct drug targeting applications. Here, we present a novel controller for microrobot maneuver by considering four key in vivo constraints non-Euclidean structure of capillaries, irreversibility of blood flow, invisibility of microvasculature, and inaccuracy of microrobot tracking. We use the taxicab geometry of capillaries as the a priori knowledge for steering and tracking a microrobot in lattice-like vessels. Furthermore, we introduce a minimax repulsive boundary function to prevent the microrobot from getting too close to the boundaries imposed by the direction of blood flow. We also propose a novel Kalman filtering algorithm to reduce tracking error, while avoiding possible obstacles such as vessel walls without knowing their actual locations. The proposed control method consists of four modules, namely a model predictive control module for tumor targeting, a Kalman filtering module for microrobot tracking, a blind obstacle detection module, and a vessel structure estimation module. The interplay of these four modules offers successful maneuver and tracking of the microrobot while avoiding obstacles in a blind manner by utilizing the taxicab geometry of blood vessels. We present a comprehensive in silico simulation study to verify our designed controller.Improper baseline return from the previous task-evoked hemodynamic response (HR) can contribute to a large variation in the subsequent HR, affecting the estimation of mental workload in brain-computer interface systems. In this study, we proposed a method using vector phase analysis to detect the baseline state as being optimal or suboptimal. We hypothesize that selecting neuronal-related HR as observed in the optimal-baseline blocks can lead to an improvement in estimating mental workload. Oxygenated and deoxygenated hemoglobin concentration changes were integrated as parts of the vector phase. The proposed method was applied to a block-design functional near-infrared spectroscopy dataset (total blocks = 1384), measured on 24 subjects performing multiple difficulty levels of mental arithmetic task. Significant differences in hemodynamic signal change were observed between the optimal- and suboptimal-baseline blocks detected using the proposed method. This supports the effectiveness of the proposed method in detecting baseline state for better estimation of mental workload. The results further highlight the need of customized recovery duration. C75 In short, the proposed method offers a practical approach to detect task-evoked signals, without the need of extra probes.For an ensemble of 3D multi-parameter fields, we present a visual analytics workflow to analyse whether and which parts of a selected multi-parameter distribution is present in all ensemble members. Supported by a parallel coordinate plot, a multi-parameter brush is applied to all ensemble members to select data points with similar multi-parameter distribution. By a combination of spatial sub-division and a covariance analysis of partitioned sub-sets of data points, a tight partition in multi-parameter space with reduced number of selected data points is obtained. To assess the representativeness of the selected multi-parameter distribution across the ensemble, we propose a novel extension of violin plots that can show multiple parameter distributions simultaneously. We investigate the visual design that effectively conveys (dis-)similarities in multi-parameter distributions, and demonstrate that users can quickly comprehend parameter-specific differences regarding distribution shape and representativeness from a side-by-side view of these plots. In a 3D spatial view, users can analyse and compare the spatial distribution of selected data points in different ensemble members via interval-based isosurface raycasting. In two real-world application cases we show how our approach is used to analyse the multi-parameter distributions across an ensemble of 3D fields.Quality of experience (QoE) that serves as a direct evaluation of viewing experience from the end users is of vital importance for network optimization, and should be constantly monitored. Unlike existing video-on-demand streaming services, real-time interactivity is critical to the mobile live broadcasting experience for both broadcasters and their audiences. While existing QoE metrics that are validated on limited video contents and synthetic stall patterns have shown effectiveness in their trained QoE benchmarks, a common caveat is that they often encounter challenges in practical live broadcasting scenarios, where one needs to accurately understand the activity in the video with fluctuating QoE and figure out what is going to happen to support the real-time feedback to the broadcaster. In this paper, we propose a temporal relational reasoning guided QoE evaluation approach for mobile live video broadcasting, namely TRR-QoE, which explicitly attends to the temporal relationships between consecutive frames to achieve a more comprehensive understanding of the distortion-aware variation. In our design, video frames are first processed by deep neural network (DNN) to extract quality-indicative features. Afterwards, besides explicitly integrating features of individual frames to account for the spatial distortion information, multi-scale temporal relational information corresponding to diverse temporal resolutions are made full use of to capture temporal-distortion-aware variation. As a result, the overall QoE prediction could be derived by combining both aspects. The results of experiments conducted on a number of benchmark databases demonstrate the superiority of TRR-QoE over the representative state-of-the-art metrics.Depth of field is an important factor of imaging systems that highly affects the quality of the acquired spatial information. Extended depth of field (EDoF) imaging is a challenging ill-posed problem and has been extensively addressed in the literature. We propose a computational imaging approach for EDoF, where we employ wavefront coding via a diffractive optical element (DOE) and we achieve deblurring through a convolutional neural network. Thanks to the end-to-end differentiable modeling of optical image formation and computational post-processing, we jointly optimize the optical design, i.e., DOE, and the deblurring through standard gradient descent methods. Based on the properties of the underlying refractive lens and the desired EDoF range, we provide an analytical expression for the search space of the DOE, which is instrumental in the convergence of the end-to-end network. We achieve superior EDoF imaging performance compared to the state of the art, where we demonstrate results with minimal artifacts in various scenarios, including deep 3D scenes and broadband imaging.