Santospettersson2653
The relationship between autoimmune haemolytic anaemia (AIHA) and antiphospholipid antibodies (aPL) has never been addressed via a meta-analysis in the paediatric age group. We evaluated the link between AIHA and aPL in childhood systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS).
EMBASE and PubMed were screened from inception to May 2020 and Peto's odds ratio for rare events was employed for the between group comparisons.
The meta-analysis included 11 articles for a total of 575 children the pooled prevalence of AIHA was greater in (1) IgG aCL-positive than IgG aCL-negative children (39.7% vs 20.9%, p = 0.005); (2) in APS-positive than APS-negative SLE children (36.8% vs 13.2%, p = 0.01); and (3) in SLE-related APS than in primary APS children (53% vs 16.2%, p = 0.008).
The pooled prevalence of AIHA is greatest in SLE with aPL/APS, low-moderate in SLE without aPL/APS, and lowest in primary APS. Key Points • Antiphospholipid antibodies strongly relate to autoimmune haemolytic anaemia. • Autoimmune haemolytic anaemia is more common in systemic lupus erythematosus with antiphospholipid antibodies.
The pooled prevalence of AIHA is greatest in SLE with aPL/APS, low-moderate in SLE without aPL/APS, and lowest in primary APS. #link# Key Points • Antiphospholipid antibodies strongly relate to autoimmune haemolytic anaemia. • Autoimmune haemolytic anaemia is more common in systemic lupus erythematosus with antiphospholipid antibodies.This paper aims at estimating the dynamic impact of renewable and non-renewable energy consumption, globalization, urbanization, and economic growth on the environmental quality. Unlike previous study, this study used multi-dimensional indicator of environmental quality that is ecological footprint. Given the importance of renewable energy, a sample of top renewable energy consuming countries has been selected for analysis spanning the period 1991-2016. The analysis is carried out in panel data framework that considers the issues of cross sectional dependence and heterogeneity. The results of cointegration test show the existence of long-run equilibrium relationship among the variables. The long-run elasticity of pooled mean group shows positive impact of economic growth and non-renewable energy consumption on ecological footprint while negative impact is observed in case of renewable energy consumption, globalization and urbanization. The sensitivity of long-run elasticity has been checked with the help of fully modified ordinary least square and dynamic ordinary least square. Based on empirical findings, some policy implication has also been provided.In this study, a novel magnetic cassava stalk composite (M-EMCS) was prepared through modification with ethylenediamine tetraacetic anhydride (EDTAD) and loading of Fe3O4. The surface morphology, molecular structure, and magnetic characteristics of the composite were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), vibrating-sample magnetometer (VSM), and X-ray diffraction (XRD). It was shown that EDTAD and Fe3O4 were successfully modified and loaded in cassava straw (CS), respectively. The capacity of M-EMCS to absorb heavy metals under different influencing factors was tested by atomic absorption spectroscopy. The adsorption processes of both Pb2+ and Zn2+ were suitably described by second-order kinetic models and Langmuir models, indicating monolayer chemisorption. M-EMCS had high adsorption rates and adsorption capacities for these two metal ions. The adsorption of Pb2+ and Zn2+ reached a plateau after 10 min, and the adsorption capacity of Pb2+ (163.93 mg/g) was higher than that of Zn2+ (84.74 mg/g). Thermodynamic analysis showed that the adsorption of two metals by M-EMCS was spontaneous, endothermic, and irreversible. XPS analysis showed that M-EMCS mainly removes Pb2+ and Zn2+ through ion exchange, chelation, and redox. Graphical abstract.Mechanical vapor compression and multi-effect evaporation have been widely used in achieving zero discharge of desulfurization wastewater as they are energy-saving and efficient technologies. Solubilized weak ions, such as CO32-, SO32-, and NH4+, in the desulfurization wastewater are partly converted into CO2, SO2, and NH3, respectively, during the vacuum evaporation process, thus affecting the heat exchange and compressor performance. In Elafibranor chemical structure , the migration and coupling mechanism of CO2, SO2, and NH3 desorption in desulfurized wastewater under vacuum evaporation were analyzed. The effects of temperature, pressure, reaction time, and other factors on the migration process were discussed. The hydrolysis and electrolytic equilibrium constants of the related ions were obtained for temperatures between 70 and 90 °C. The results demonstrate the relationship between the desorption capacities of CO2, SO2, and NH3 and the hydrolysis constants of their respective ions. The desorption of CO2 and NH3 increased significantly when CO32- and NH4+ coexisted, whereas the SO2 desorption capacity remained low under the same experimental conditions. The experimental results indicate that the desorption of CO2, SO2, and NH3 is controlled by chemical reactions and can be described by first-order reaction kinetics.Genetic studies have investigated the pathogenesis of age-related macular degeneration (AMD). The pachychoroid concept has recently garnered attention as a possible explanation for AMD pathogenesis; the genetic characteristics of pachychoroid diseases have also been elucidated. In this review, we summarize previously reported genetic characteristics of AMD and pachychoroid diseases, and analyze these data to understand the pathogenesis of AMD and pachychoroid diseases. Previous studies show that VIPR2 and the CFH I62V A allele promote development of pachychoroid and central serous chorioretinopathy (CSC), while the CFH I62V G allele promotes development of drusen, pachychoroid neovasculopathy (PCN/PNV), and AMD. ARMS2/HTRA1 also promotes development of drusen, PCN/PNV, and AMD. TNFRSF10A and GATA5 are associated with CSC but not with pachychoroid, and TNFRSF10A is associated with AMD that includes PCN/PNV. These genetic characteristics suggest the following mechanisms of developing AMD and pachychoroid diseases. VIPR2 and the CFH I62V A allele promote pachychoroid development, which can result in CSC development. The CFH I62V G allele promotes a common step during PCN/PNV and AMD development induced by pachychoroid or drusen, such as damage of Bruch's membrane or retinal pigment epithelium (RPE). ARMS2/HTRA1 also promotes damage of Bruch's membrane or RPE, while the association with drusen formation is stronger in ARMS2/HTRA1 than in CFH. TNFRSF10A and GATA5 promote blood-retinal-barrier breakdown to induce CSC, which could lead to PCN/PNV development. Furthermore, recently reported genetic associations with the natural course of CSC suggest the importance of reconsidering the subtype classification of CSC. link2 These associations would enable the development of personalized/precision medicine for CSC and.Franco Andrea Bonelli, a disciple of Lamarck, was one of the few naturalists who taught and disseminated transformism in Italy in the early nineteenth century. The explanation of the history of life on Earth offered by Lamarck's theory was at odds with the Genesis narrative, while the issue of man's place in nature raised heated debates. Bonelli sought to reconcile science and religion through his original interpretation of the variability of species, but he also focused on anthropological subjects. Following Blumenbach's studies, he investigated the differences within the human species and explored the topic of humans' alleged superiority over animals. The origin of human beings, their history, and their relationship with the rest of life were thus read in light of transformism. According to Bonelli, such questions would not do irreparable damage to the new theory. On the contrary, he considered evolution not only acceptable but even necessary to protect the Holy Texts from certain dangerous trends in anthropological and zoological research.
The US FDA is interested in a tool that would enable pharmacovigilance safety evaluators to automate the identification of adverse drug events (ADEs) mentioned in FDA prescribing information. The MITRE Corporation (MITRE) and the FDA organized a shared task-Adverse Drug Event Evaluation (ADE Eval)-to determine whether the performance of algorithms currently used for natural language processing (NLP) might be good enough for real-world use.
ADE Eval was conducted to evaluate a range of NLP techniques for identifying ADEs mentioned in publicly available FDA-approved drug labels (package inserts). It was designed specifically to reflect pharmacovigilance practices within the FDA and model possible pharmacovigilance use cases.
Pharmacovigilance-specific annotation guidelines and annotated corpora were created. Two metrics modeled the experiences of FDA safety evaluators one measured the ability of an algorithm to identify correct Medical Dictionary for Regulatory Activities (MedDRA
) terms for the text from the annotated corpora, and the other assessed the quality of evidence extracted from the corpora to support the selected MedDRA
term by measuring the portion of annotated text an algorithm correctly identified. A third metric assessed the cost of correcting system output for subsequent training (averaged, weighted F1-measure for mention finding).
In total, 13 teams submitted 23 runs the top MedDRA
coding F1-measure was 0.79, the top quality score was 0.96, and the top mention-finding F1-measure was 0.89.
While NLP techniques do not perform at levels that would allow them to be used without intervention, it is now worthwhile exploring making NLP outputs available in human pharmacovigilance workflows.
While NLP techniques do not perform at levels that would allow them to be used without intervention, it is now worthwhile exploring making NLP outputs available in human pharmacovigilance workflows.The high-order structure of mitotic chromosomes remains to be fully elucidated. How nucleosomes compact at various structural levels into a condensed mitotic chromosome is unclear. link3 Cryogenic preservation and imaging have been applied for over three decades, keeping biological structures close to the native in vivo state. Despite being extensively utilized, this field is still wide open for mitotic chromosome research. In this review, we focus specifically on cryogenic efforts for determining the mitotic nanoscale chromatin structures. We describe vitrification methods, current status, and applications of advanced cryo-microscopy including future tools required for resolving the native architecture of these fascinating structures that hold the instructions to life.
Familial chylomicronemia syndrome (FCS) is characterized by severe fasting hypertriglyceridemia, abdominal pain, and recurrent acute pancreatitis. Available triglyceride-lowering drugs are insufficient to avoid pancreatitis. Therefore, there is a significant unmet medical need for effective triglyceride-lowering drugs for patients with FCS.
We report the second case of a patient with FCS and recurrent pancreatitis treated with lomitapide. Lomitapide treatment resulted in a reduction of fasting TG levels from 2897 mg/dL (32.71 mmol/L) to an average of 954 mg/dL (10.77 mmol/L) on the 30 mg lomitapide equating to a 67% reduction from baseline. After 26 months of lomitapide treatment, histological activity score for hepatic fibrosis was stable although liver biopsy showed a marked increase of liver steatosis and mild perivenular and perisinusoidal fibrosis.
Lomitapide is effective in reducing triglycerides in FCS and preventing the recurrence of acute pancreatitis. A longer follow-up is necessary to evaluate long-term risk of progression toward severe stages of liver fibrosis.
